{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:27:05Z","timestamp":1771644425697,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"663","license":[{"start":{"date-parts":[[1981,1,1]],"date-time":"1981-01-01T00:00:00Z","timestamp":347155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,1,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A family suffering from cranial diabetes insipidus, that extends over 4 generations, is described. Inheritance of polyuria was autosomal dominant. Vasopressin function was studied in members of the last 2 generations, 4 of whom had polyuria. Osmoregulation of vasopressin secretion was assessed by infusion of hypertonic saline. Plasma vasopressin remained undetectable in one patient, while 2 others had very blunted vasopressin responses to osmotic stimulation. Three non-osmotic stimuli were applied. Controlled hypotension produced by trimetaphan infusion and insulin-induced hypoglycaemia did not increase plasma vasopressin but apomorphine-induced nausea caused a minimal rise in plasma vasopressin to 0.7 pg\/ml. Polyuria and thirst resolved with antidiuretic therapy in all patients studied.<\/jats:p><jats:p>Congenital absence of vasopressin as in Brattleboro rats is unlikely to account for diabetes insipidus in this disorder since small increases in vasopressin have been demonstrated in these patients. In view of previous post-mortem findings, familial cranial diabetes insipidus is most likely to be due to degeneration of vasopressin-synthesizing neurones.<\/jats:p>","DOI":"10.1136\/pgmj.57.663.36","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"36-40","source":"Crossref","is-referenced-by-count":29,"title":["Vasopressin function in familial cranial diabetes insipidus"],"prefix":"10.1093","volume":"57","author":[{"given":"P H","family":"Baylis","sequence":"first","affiliation":[{"name":"Department of Medicine, Indiana University Medical Center and V.A. Hospital , Indianapolis, Indiana , U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G L","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University Medical Center and V.A. Hospital , Indianapolis, Indiana , U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1981,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1042\/cs057023Pc","article-title":"Vasopressin response to insulin-induced hypoglycaemia in man","volume":"57","author":"BAYLIS, P.H.; ROBERTSON, G.L.","year":"1979","unstructured":"BAYLIS, P.H. & ROBERTSON, G.L. (1979) Vasopressin response to insulin-induced hypoglycaemia in man. Clinical Science, 57, 23.","journal-title":"Clinical Science"},{"key":"ref_2","first-page":"191","article-title":"Primary or idiopathic diabetes insipidus: a system disease","volume":"7","author":"BLOTNER, H.","year":"1958","unstructured":"BLOTNER, H. (1958) Primary or idiopathic diabetes insipidus: a system disease. Metabolism, 7, 191.","journal-title":"Metabolism"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.7326\/0003-4819-63-3-503","article-title":"Hereditary idiopathic diabetes insipidus","volume":"63","author":"BRAVERMAN, L.E.; MANCINI, J.P.; MCGOLDRICK, D.","year":"1965","unstructured":"BRAVERMAN, L.E., MANCINI, J.P. & MCGOLDRICK, D. (1965) Hereditary idiopathic diabetes insipidus. Annals ofInternal Medicine, 63, 503.","journal-title":"Annals ofInternal Medicine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1210\/jcem-7-11-753","article-title":"The use of hypertonic saline infusion in the differential diagnosis of diabetes insipidus and psychogenic polydipsia","volume":"7","author":"CARTER, A.C.; ROBBINS, J.","year":"1947","unstructured":"CARTER, A.C. & ROBBINS, J. (1947) The use of hypertonic saline infusion in the differential diagnosis of diabetes insipidus and psychogenic polydipsia. Journal of Clinical Endocrinology and Metabolism, 7, 753.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_5","first-page":"1","article-title":"Juvenile diabetes mellitus, optic atrophy, hearing loss, diabetes insipidus, atonia of the urinary tract and bladder, and other abnormalities (Wolfram syndrome)","volume":"264","author":"CREMERS, C.W.R.J.; WIJDEVELD, P.G.A.B.; PINCKERS, A.J.L.G.","year":"1977","unstructured":"CREMERS, C.W.R.J., WIJDEVELD, P.G.A.B. & PINCKERS, A.J.L.G. (1977) Juvenile diabetes mellitus, optic atrophy, hearing loss, diabetes insipidus, atonia of the urinary tract and bladder, and other abnormalities (Wolfram syndrome). Acta paediatrica scandinavica, 264 (Suppl.), 1.","journal-title":"Acta paediatrica"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1001\/jama.1963.03060090031011","article-title":"A water deprivation test for the differential diagnosis of polyuria","volume":"185","author":"DASHE, A.M.; CRAMM, R.E.; CRIST, C.A.; HABENER, J.F.; SOLOMON, D.H.","year":"1963","unstructured":"DASHE, A.M., CRAMM, R.E., CRIST, C.A., HABENER, J.F. & SOLOMON, D.H. (1963) A water deprivation test for the differential diagnosis of polyuria. Journal of the American Medical Association, 185, 699.","journal-title":"Journal of the American Medical Association"},{"key":"ref_7","first-page":"1","article-title":"On hereditary diabetes insipidus","volume":"159","author":"FORSSMAN, H.","year":"1945","unstructured":"FORSSMAN, H. (1945) On hereditary diabetes insipidus. Acta medica scandinavica, 159 (Suppl.), 1.","journal-title":"Acta medica"},{"key":"ref_8","first-page":"21","article-title":"Two mutations of the X-chromosome causing diabetes insipidus","volume":"7","author":"FORSSMAN, H.","year":"1955","unstructured":"FORSSMAN, H. (1955) Two mutations of the X-chromosome causing diabetes insipidus. American Journal of Human Genetics, 7, 21.","journal-title":"American Journal of Human Genetics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1210\/jcem-15-5-547","article-title":"Hereditary diabetes insipidus: report of 20 cases in 7 generations","volume":"15","author":"LEVINGER, E.L.; ESCAMILLA, R.F.","year":"1955","unstructured":"LEVINGER, E.L. & ESCAMILLA, R.F. (1955) Hereditary diabetes insipidus: report of 20 cases in 7 generations. Journal of Clinical Endocrinology and Metabolism, 15, 547.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1001\/jama.1955.02960090019005a","article-title":"Familial diabetes insipidus","volume":"158","author":"MOEHLIG, R.C.; SCHULTZ, R.C.","year":"1955","unstructured":"MOEHLIG, R.C. & SCHULTZ, R.C. (1955) Familial diabetes insipidus. Journal of the American Medical Association, 158, 725.","journal-title":"Journal of the American Medical Association"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/pgmj.55.644.377","article-title":"Diabetes insipidus, diabetes mellitus, optic atrophy and deafness. A clinical and genetic study","volume":"55","author":"NAGI, N.A.","year":"1979","unstructured":"NAGI, N.A. (1979) Diabetes insipidus, diabetes mellitus, optic atrophy and deafness. A clinical and genetic study. Postgraduate Medical Journal, 55, 377.","journal-title":"Postgraduate Medical Journal"},{"key":"ref_12","first-page":"505","article-title":"Recessive inheritance of diabetes: the syndrome of diabetes insipidus, diabetes mellitus, optic atrophy and deafness","volume":"45","author":"PAGE, M.McB; ASMAL, A.C.; EDWARDS, C.R.W.","year":"1976","unstructured":"PAGE, M.McB., ASMAL, A.C. & EDWARDS, C.R.W. (1976) Recessive inheritance of diabetes: the syndrome of diabetes insipidus, diabetes mellitus, optic atrophy and deafness. Quarterly Journal of Medicine, 45, 505.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1542\/peds.11.3.246","article-title":"Dominant inheritance of diabetes insipidus","volume":"11","author":"PENDER, C.B.; FRASER, F.C.","year":"1953","unstructured":"PENDER, C.B. & FRASER, F.C. (1953) Dominant inheritance of diabetes insipidus. Pediatrics, 11, 246.","journal-title":"Pediatrics"},{"key":"ref_14","first-page":"333","article-title":"The regulation of vasopressin function in health and disease","volume":"33","author":"ROBERTSON, G.L.","year":"1977","unstructured":"ROBERTSON, G.L. (1977) The regulation of vasopressin function in health and disease. Recent Progress in Hormone Research, 33, 333.","journal-title":"Recent Progress in Hormone Research"},{"key":"ref_15","first-page":"247","article-title":"The physiopathology of ADH In: Clinical Neuroendocrinology: A","author":"ROBERTSON, G.L.","year":"1979","unstructured":"ROBERTSON, G.L. (1979) The physiopathology of ADH In: Clinical Neuroendocrinology: A Pathophysiological Approach (Ed by Tolis, G.), p. 247. Raven Press, New York."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1172\/JCI107423","article-title":"Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma","volume":"52","author":"ROBERTSON, G.L.; MAHR, E.A.; ATHAR, S.; SINHA, T.","year":"1973","unstructured":"ROBERTSON, G.L., MAHR, E.A., ATHAR, S. & SINHA, T. (1973) Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma. Journal of Clinical Investigation, 52, 2340.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/jmg.9.4.408","article-title":"Pedigrees with diabetes insipidus, diabetes mellitus and optic atrophy","volume":"9","author":"SUNDER, J.H.; DANOWSKI, T.S.; KENNY, F.M.; KHURANA, R.C.; SUN, A.; NOLAN, S.; STEPHAN, T.","year":"1972","unstructured":"SUNDER, J.H., DANOWSKI, T.S., KENNY, F.M., KHURANA, R.C., SUN, A., NOLAN, S. & STEPHAN, T. (1972) Pedigrees with diabetes insipidus, diabetes mellitus and optic atrophy. Journal of Medical Genetics, 9, 408.","journal-title":"Journal of Medical Genetics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/0002-9343(67)90098-8","article-title":"Hereditary hypothalamic diabetes insipidus in rats (Brattleboro strain)","volume":"42","author":"VALTIN, H.","year":"1967","unstructured":"VALTIN, H. (1967) Hereditary hypothalamic diabetes insipidus in rats (Brattleboro strain). American Journal of Medicine, 42, 814.","journal-title":"American Journal of Medicine"},{"key":"ref_19","first-page":"447","article-title":"Genetic approaches to the study of the regulation and actions of vasopressin","volume":"31","author":"VALTIN, H.; SOKOL, H.W.; SUNDE, D.","year":"1975","unstructured":"VALTIN, H., SOKOL, H.W. & SUNDE, D. (1975) Genetic approaches to the study of the regulation and actions of vasopressin. Recent Progress in Hormone Research, 31, 447.","journal-title":"Recent Progress in Hormone Research"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S0022-5347(17)68700-7","article-title":"Hereditary diabetes insipidus: unusual urinary tract changes","volume":"63","author":"WELLER, C.G.; ELLIOTT, W.; GUSMAN, A.R.","year":"1950","unstructured":"WELLER, C.G., ELLIOTT, W. & GUSMAN, A.R. (1950) Hereditary diabetes insipidus: unusual urinary tract changes. 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