{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T23:58:50Z","timestamp":1761955130299,"version":"build-2065373602"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"664","license":[{"start":{"date-parts":[[1981,2,1]],"date-time":"1981-02-01T00:00:00Z","timestamp":349833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>In a 33-year-old patient with severe primary pulmonary hypertension, the acute administration of the angiotensin-converting-enzyme inhibitor captopril (SQ 14,225) induced a rise in cardiac output, and a fall in both pulmonary and systemic vascular resistance. Subsequent chronic oral administration of captopril induced only transient clinical improvement, and the patient died. Captopril may nevertheless be useful in the treatment of less advanced cases of this disease.<\/jats:p>","DOI":"10.1136\/pgmj.57.664.115","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"115-116","source":"Crossref","is-referenced-by-count":13,"title":["Effects of captopril (SQ 14,225) in a patient with primary pulmonary hypertension"],"prefix":"10.1093","volume":"57","author":[{"given":"J D","family":"Horowitz","sequence":"first","affiliation":[{"name":"Departments of Cardiology, Medicine and Clinical Pharmacology, Austin Hospital , Melbourne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J B","family":"Brennan","sequence":"additional","affiliation":[{"name":"Departments of Cardiology, Medicine and Clinical Pharmacology, Austin Hospital , Melbourne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L E","family":"Oliver","sequence":"additional","affiliation":[{"name":"Departments of Cardiology, Medicine and Clinical Pharmacology, Austin Hospital , Melbourne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Harding","sequence":"additional","affiliation":[{"name":"Departments of Cardiology, Medicine and Clinical Pharmacology, Austin Hospital , Melbourne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Goble","sequence":"additional","affiliation":[{"name":"Departments of Cardiology, Medicine and Clinical Pharmacology, Austin Hospital , Melbourne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W J","family":"Louis","sequence":"additional","affiliation":[{"name":"Departments of Cardiology, Medicine and Clinical Pharmacology, Austin Hospital , Melbourne"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1981,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1161\/01.CIR.58.5.763","article-title":"Role of the reinin-angiotensin system in the systemic vasoconstriction of chronic congestic heart failure","volume":"58","author":"CURTISS, C.; COHN, J.N.; VROBEL, T.; FRANCIOSA, J.A.","year":"1978","unstructured":"CURTISS, C., COHN, J.N., VROBEL, T. & FRANCIOSA, J.A. (1978) Role of the reinin-angiotensin system in the systemic vasoconstriction of chronic congestic heart failure. Circulation, 58, 763.","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0014-2999(79)90491-6","article-title":"The effects of Captopril (SQ 14,225) on bradykinin-induced bronchoconstriction in the anaesthetized guinea-pig","volume":"57","author":"GREENBERG, R.; OSMAN, G.H.; O'KEEFE, E.H.; ANTONACCIO, M.J.","year":"1979","unstructured":"GREENBERG, R., OSMAN, G.H., O'KEEFE, E.H. & ANTONACCIO, M.J. (1979) The effects of Captopril (SQ 14,225) on bradykinin-induced bronchoconstriction in the anaesthetized guinea-pig. European Journal of Pharmacology, 57, 287.","journal-title":"European Journal of Pharmacology"},{"issue":"1","key":"ref_3","first-page":"40","article-title":"The mechanism of bradykinin potentiation after inhibition ofangiotensin-converting enzyme ofSQ 14,225 in conscious rabbits","volume":"43","author":"MURTHY, V.S.; WALDRON, T.L.; GOLDBERG, M.E.","year":"1978","unstructured":"MURTHY, V.S., WALDRON, T.L. & GOLDBERG, M.E. (1978) The mechanism of bradykinin potentiation after inhibition ofangiotensin-converting enzyme ofSQ 14,225 in conscious rabbits. Circulation Research, 43 (Suppl. 1), 40.","journal-title":"Circulation Research"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/0002-9343(79)90735-6","article-title":"Effects of the converting enzyme inhibitor (SQ 20,881) on the pulmonary circulation in man","volume":"67","author":"NIARCHOS, A.P.; ROBERTS, A.J.; LARAGH, J.H.","year":"1979","unstructured":"NIARCHOS, A.P., ROBERTS, A.J. & LARAGH, J.H. 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New England Journal of Medicine, 302, 69.","journal-title":"New England Journal of Medicine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"772","DOI":"10.7326\/0003-4819-90-5-772","article-title":"Primary pulmonary hypertension treated with oral phentolamine","volume":"90","author":"RUSKIN, J. N. & HUTTER Jr, A. M","year":"1979","unstructured":"RUSKIN, J.N. & HUTTER Jr, A.M. (1979) Primary pulmonary hypertension treated with oral phentolamine. Annals of Internal Medicine, 90, 772.","journal-title":"Annals of Internal Medicine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1161\/01.CIR.26.6.1358","article-title":"Primary pulmonary hypertension: Review of clinical features and pathological physiology, with a report of pulmonary hemodynamics derived from repeated catheterization","volume":"26","author":"SLEEPER, J.C.; ORGAIN, E.S.; MCINTOSH, H.D.","year":"1962","unstructured":"SLEEPER, J.C., ORGAIN, E.S. & MCINTOSH, H.D. 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