{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T17:41:24Z","timestamp":1683740484156},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"665","license":[{"start":{"date-parts":[[1981,3,1]],"date-time":"1981-03-01T00:00:00Z","timestamp":352252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,3,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The platelet aggregate ratio has been found to be decreased in some patients with vascular diseases suggesting the presence of increased circulating platelet aggregates. It has also been reported that hypercholesterolaemia is associated with an enhanced response of platelets to aggregating agents in platelet-rich plasma. The primary purpose of this investigation was to determine correlation of the platelet aggregate ratio with the serum cholesterol concentration of men with vascular diseases. For 52 men referred because of known or suspected coronary artery disease, cerebrovascular disease, or venous thromboembolism, the correlation coefficient of 0\u00b706 suggested that the serum cholesterol concentration within the range observed (135-360 mg\/dl) was not a factor influencing the platelet aggregate ratio. There was not a statistically significant difference between the mean platelet aggregate ratios or the mean serum cholesterol concentrations of the 21 non-smokers and the 31 smokers studied. A correlation coefficient of 0\u00b703 between the platelet aggregate ratio and age of the patient suggested that the platelet aggregate ratio was independent of age in men with occlusive vascular diseases.<\/jats:p>","DOI":"10.1136\/pgmj.57.665.150","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"150-152","source":"Crossref","is-referenced-by-count":2,"title":["Relationships of the platelet aggregate ratio to serum cholesterol concentration, smoking and age"],"prefix":"10.1093","volume":"57","author":[{"given":"James W","family":"Davis","sequence":"first","affiliation":[{"name":"Veterans Administration Medical Center , Kansas City, Missouri"},{"name":"Department of Medicine, University of Kansas School of Medicine , Kansas City, Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"H Daniel","family":"Lewis","sequence":"additional","affiliation":[{"name":"Veterans Administration Medical Center , Kansas City, Missouri"},{"name":"Department of Medicine, University of Kansas School of Medicine , Kansas City, Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyllis E","family":"Phillips","sequence":"additional","affiliation":[{"name":"Veterans Administration Medical Center , Kansas City, Missouri"},{"name":"Department of Medicine, University of Kansas School of Medicine , Kansas City, Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca F","family":"Davis","sequence":"additional","affiliation":[{"name":"Veterans Administration Medical Center , Kansas City, Missouri"},{"name":"Department of Medicine, University of Kansas School of Medicine , Kansas City, Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1981,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1056\/NEJM197402212900805","article-title":"Platelet function in hyperlipoproteinemia","volume":"290","author":"CARVALHO, A.C.A.; COLMAN, R.W.; LEES, R.S.","year":"1974","unstructured":"CARVALHO, A.C.A., COLMAN, R.W. & LEES, R.S. (1974) Platelet function in hyperlipoproteinemia. New England Journal of Medicine, 290, 434.","journal-title":"New England Journal of Medicine"},{"key":"ref_2","first-page":"236","article-title":"Interrelationship of CPA, r-TG and in vitro platelet aggregometry for the detection of platelet hyperaggregability","volume":"1","author":"CHEN, Y.C.; WEINER, W.J.; WALASEK, J.; SMITH-MCKEARN, C.; Wu, K.K.","year":"1979","unstructured":"CHEN, Y.C., WEINER, W.J., WALASEK, J., SMITH-MCKEARN, C. & Wu, K.K. (1979) Interrelationship of CPA, r-TG and in vitro platelet aggregometry for the detection of platelet hyperaggregability. Blood, (Suppl. 1), 236a.","journal-title":"Blood"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00000441-197909000-00004","article-title":"Acute effect of tobacco cigarette smoking on the platelet aggregate ratio","volume":"278","author":"DAVIS, J.W.; DAVIS, R.F.","year":"1979","unstructured":"DAVIS, J.W. & DAVIS, R.F. (1979) Acute effect of tobacco cigarette smoking on the platelet aggregate ratio. American Journal of the Medical Sciences, 278, 139.","journal-title":"American Journal of the Medical Sciences"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1001\/archinte.1981.00340020068019","article-title":"Prevention of cigarette smoking-induced platelet aggregate formation by aspirin","volume":"141","author":"DAVIS, J.W.; DAVIS, R.F.","year":"1980","unstructured":"DAVIS, J.W. & DAVIS, R.F. (1980) Prevention of cigarette smoking-induced platelet aggregate formation by aspirin. Archives of Internal Medicine, 141, 206.","journal-title":"Archives of Internal Medicine"},{"key":"ref_5","article-title":"Platelet activation in acute cerebral ischaemia: serial measurements of platelet function in cerebrovascular disease","volume":"821","year":"1977","unstructured":"DOUGHERTY Jr, J.H., LEVY, D.E. & WEKSLER, B.B. (1977) Platelet activation in acute cerebral ischaemia: serial measurements of platelet function in cerebrovascular disease. Lancet, i, 821.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/00365517709091490","article-title":"High density lipoproteins (HDL) and physical activity: The influence of physical exercise, age and smoking on HDL-cholesterol and the HDL-\/total cholesterol ratio","volume":"37","author":"ENGER, S.C.; HERBJ0RNSEN, K.; ERIKSSEN, J.; FRETLAND, A.","year":"1977","unstructured":"ENGER, S.C., HERBJ0RNSEN, K., ERIKSSEN, J. & FRETLAND, A. (1977) High density lipoproteins (HDL) and physical activity: The influence of physical exercise, age and smoking on HDL-cholesterol and the HDL-\/total cholesterol ratio. Scandinavian Journal of Clinical and Laboratory Investigation, 37, 251.","journal-title":"Scandinavian Journal of Clinical and Laboratory Investigation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1055\/s-0038-1651875","article-title":"Chronic effect of smoking on platelet count and 'platelet adhesiveness' in presumably healthy middle-aged men","volume":"38","author":"ERIKSSEN, J.; HELLEM, A.; STORMORKEN, H.","year":"1977","unstructured":"ERIKSSEN, J., HELLEM, A. & STORMORKEN, H. (1977) Chronic effect of smoking on platelet count and 'platelet adhesiveness' in presumably healthy middle-aged men. Thrombosis and Haemostasis, 38, 606.","journal-title":"Thrombosis and Haemostasis"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-0609.1976.tb01176.x","article-title":"Platelet function and plasma free fatty acids during acute myocardial infarction and severe angina pectoris","volume":"17","author":"GJESDAL, K.","year":"1976","unstructured":"GJESDAL, K. (1976) Platelet function and plasma free fatty acids during acute myocardial infarction and severe angina pectoris. Scandinavian Journal of Haematology, 17, 205.","journal-title":"Scandinavian Journal of Haematology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1177\/000331977702801006","article-title":"Peripheral venous platelet aggregates in patients with unstable angina pectoris and acute myocardial infarction","volume":"28","author":"GUYTON, J.R.; WILLERSON, J.P.","year":"1977","unstructured":"GUYTON, J.R. & WILLERSON, J.P. (1977) Peripheral venous platelet aggregates in patients with unstable angina pectoris and acute myocardial infarction. Angiology, 28, 695.","journal-title":"Angiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1182\/blood.V53.4.604.604","article-title":"Platelet x-granule proteins: studies on release and subcellular localization","volume":"53","author":"KAPLAN, K.L.; BROEKMAN, M.J.; CHERNOFF, A.; LESZNIK, G.R.; DRILLINGS, M.","year":"1979","unstructured":"KAPLAN, K.L., BROEKMAN, M.J., CHERNOFF, A., LESZNIK, G.R. & DRILLINGS, M. (1979) Platelet x-granule proteins: studies on release and subcellular localization. Blood, 53, 604.","journal-title":"Blood"},{"key":"ref_11","article-title":"Cigarette smoking, serum-cholesterol, bloodpressure, and body fatness: observations","volume":"492","author":"KARVONEN, M.; ORMA, E.; KEYS, A.; FIDANZA, F.; BROZEK, J.","year":"1959","unstructured":"KARVONEN, M., ORMA, E., KEYS, A., FIDANZA, F. & BROZEK, J. 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Lancet, ii, 924.","journal-title":"Lancet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1161\/01.STR.6.5.521","article-title":"Increased platelet aggregates in patients with transient ischemic attacks","volume":"6","author":"Wu, K.K.; HOAK, J.C.","year":"1975","unstructured":"Wu, K.K. & HOAK, J.C. (1975) Increased platelet aggregates in patients with transient ischemic attacks. Stroke, 6, 521.","journal-title":"Stroke"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/57\/665\/150\/50216145\/postgradmedj-57-150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/57\/665\/150\/50216145\/postgradmedj-57-150.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T17:26:31Z","timestamp":1683739591000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/57\/665\/150\/7050279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,3,1]]},"references-count":24,"journal-issue":{"issue":"665","published-online":{"date-parts":[[1981,3,1]]},"published-print":{"date-parts":[[1981,3,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.57.665.150","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1981,3]]},"published":{"date-parts":[[1981,3,1]]}}}