{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T22:29:41Z","timestamp":1772058581309,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"669","license":[{"start":{"date-parts":[[1981,7,1]],"date-time":"1981-07-01T00:00:00Z","timestamp":362793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,7,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Three women with hypoparathyroidism are described who developed severe symptomatic hypercalcaemia while being treated with alphacalcidol (1 alpha-hydroxycholecalciferol; One-Alpha). One sustained permanent renal damage. Alphacalcidol may have advantages over calciferol in its speed of action but poisoning may be more likely to occur. Frequent follow-up checks on the plasma calcium is needed for any patient on alphacalcidol. For long-term management calciferol may still be the drug of choice.<\/jats:p>","DOI":"10.1136\/pgmj.57.669.431","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"431-432","source":"Crossref","is-referenced-by-count":6,"title":["Hypercalcaemia in alphacalcidol therapy"],"prefix":"10.1093","volume":"57","author":[{"given":"C R","family":"Paterson","sequence":"first","affiliation":[{"name":"University Department of Biochemical Medicine, Ninewells Hospital , Dundee DD1 9SY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1981,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1172\/JCI108424","article-title":"Comparison of effects of loc-hydroxy-vitamin D and 1,25-dihydroxyvitamin D in man","volume":"57","author":"BRICKMAN, A.S.; COBURN, J.W.; FRIEDMAN, G.R.; OKAMURA, W.H.; MASSRY, S.G.; NORMAN, A.W.","year":"1976","unstructured":"BRICKMAN, A.S., COBURN, J.W., FRIEDMAN, G.R., OKAMURA, W.H., MASSRY, S.G. & NORMAN, A.W. (1976) Comparison of effects of loc-hydroxy-vitamin D and 1,25-dihydroxyvitamin D in man. Journal of Clinical Investigation, 57, 1540.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_2","article-title":"Vitamin-D analogues and renal function","volume":"386","author":"COMPSTON, J.E.; HORTON, L.W.L.; LAKER, M.F.","year":"1979","unstructured":"COMPSTON, J.E., HORTON, L.W.L. & LAKER, M.F. (1979) Vitamin-D analogues and renal function. Lancet, i, 386.","journal-title":"Lancet"},{"key":"ref_3","article-title":"The continuing risk of vitamin-D intoxication","volume":"621","author":"DAVIES, M.; ADAMS, P.H.","year":"1978","unstructured":"DAVIES, M. & ADAMS, P.H. (1978) The continuing risk of vitamin-D intoxication. Lancet,;;, 621.","journal-title":"Lancet"},{"key":"ref_4","article-title":"1,25-dihydroxycholecalciferol in hypoparathyroidism","volume":"55","author":"DAVIES, M.; HILL, L.F.; TAYLOR, C.M.; STANBURY, S.W.","year":"1977","unstructured":"DAVIES, M., HILL, L.F., TAYLOR, C.M. & STANBURY, S.W. (1977) 1,25-dihydroxycholecalciferol in hypoparathyroidism. Lancet, i, 55.","journal-title":"Lancet"},{"key":"ref_5","author":"GERTNER, J.M.; HODSMAN, A.B.; NEUBERGER, J.N.","year":"1976","unstructured":"GERTNER, J.M., HODSMAN, A.B. & NEUBERGER, J.N. (1976)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/bmj.1.6053.78","article-title":"Rate of reversal of hypercalcaemia and hypercalciuria induced by vitamin D and its loc-hydroxylated derivatives","volume":"1","author":"KANIS, J.A.; RUSSELL, R.R.G.","year":"1977","unstructured":"KANIS, J.A. & RUSSELL, R.R.G. (1977) Rate of reversal of hypercalcaemia and hypercalciuria induced by vitamin D and its loc-hydroxylated derivatives. British Medical Journal, 1, 78.","journal-title":"British Medical Journal"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJM197510232931702","article-title":"Treatment of hypoparathyroidism and pseudohypoparathyroidism with metabolites of vitamin D: evidence for impaired conversion of 25-hydroxyvitamin D to loc-25dihydroxyvitamin D","volume":"293","author":"KOOH, S.W.; FRASER, D.; DELUCA, H.F.; HOLICK, M.F.; BELSEY, R.E.; CLARK, M.B.; MURRAY, T.M.","year":"1975","unstructured":"KOOH, S.W., FRASER, D., DELUCA, H.F., HOLICK, M.F., BELSEY, R.E., CLARK, M.B. & MURRAY, T.M. (1975) Treatment of hypoparathyroidism and pseudohypoparathyroidism with metabolites of vitamin D: evidence for impaired conversion of 25-hydroxyvitamin D to loc-25dihydroxyvitamin D. New England Journal of Medicine, 293, 840.","journal-title":"New England Journal of Medicine"},{"key":"ref_8","first-page":"533","article-title":"Studies of hypoparathyroidism and pseudohypoparathyroidism","volume":"47","author":"LEWIN, I.G.; PAPAPOULOS, S.E.; TOMLINSON, S.; HENDY, G.N.; O'RIORDAN, J.L.H.","year":"1975","unstructured":"LEWIN, I.G., PAPAPOULOS, S.E., TOMLINSON, S., HENDY, G.N. & O'RIORDAN, J.L.H. (1975) Studies of hypoparathyroidism and pseudohypoparathyroidism. Quarterly Journal of Medicine, 47, 533.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/0026-0495(75)90055-4","article-title":"Effects of la-hydroxy-vitamin D, and 1,25-dihydroxy-vitamin D3 on calcium and phosphorus metabolism in hypoparathyroidism","volume":"24","author":"NEER, R.M.; HOLICK, M.F.; POTTS, J.T.","year":"1975","unstructured":"NEER, R.M., HOLICK, M.F. & POTTS, J.T. (1975) Effects of la-hydroxy-vitamin D, and 1,25-dihydroxy-vitamin D3 on calcium and phosphorus metabolism in hypoparathyroidism. Metabolism, 24, 1403.","journal-title":"Metabolism"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/S0140-6736(80)91620-7","article-title":"Vitamin-D poisoning: survey of causes in 21 patients with hypercalcaemia","volume":"1","author":"PATERSON, C.R.","year":"1980","unstructured":"PATERSON, C.R. (1980) Vitamin-D poisoning: survey of causes in 21 patients with hypercalcaemia. Lancet, 1, 1164.","journal-title":"Lancet"},{"key":"ref_11","article-title":"1,25-dihydroxycholecalciferol and la-hydroxycholecalciferol in hypoparathyroidism","volume":"14","author":"RUSSELL, R.G.G.; SMITH, R.; WALTON, R.J.; PRESTON, C.; BASSON, R.; HENDERSON, R.G.; NORMAN, A.W.","year":"1974","unstructured":"RUSSELL, R.G.G., SMITH, R., WALTON, R.J., PRESTON, C., BASSON, R., HENDERSON, R.G. & NORMAN, A.W. (1974) 1,25-dihydroxycholecalciferol and la-hydroxycholecalciferol in hypoparathyroidism. 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