{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:25Z","timestamp":1761058885111},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"675","license":[{"start":{"date-parts":[[1982,1,1]],"date-time":"1982-01-01T00:00:00Z","timestamp":378691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Six patients with non-infected synovial effusions, associated either with inflammatory or degenerative arthropathy and requiring diagnostic or therapeutic aspiration, were given a short course of 400 mg metronidazole (Flagyl) 8-hourly for 3 doses. Serum and synovial fluid (SF) were sampled frequently during this time, and assayed for metronidazole by a specific high pressure liquid-chromatographic method. It was found that concentrations of metronidazole in SF reached those in serum after a short time-lag, and thereafter approximated to the serum concentration. With this regimen, metronidazole concentrations were readily achieved in synovial fluid, above the minimum inhibitory concentrations for most susceptible anaerobes. These results indicate that the drug freely enters the synovial fluid and suggests that metronidazole would prove effective in the treatment of septic arthritis due to anaerobic bacteria.<\/jats:p>","DOI":"10.1136\/pgmj.58.675.20","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"20-24","source":"Crossref","is-referenced-by-count":9,"title":["The penetration of metronidazole into synovial fluid"],"prefix":"10.1093","volume":"58","author":[{"given":"M A","family":"Sattar","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Southampton General Hospital , Southampton S09 4XY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M G","family":"Sankey","sequence":"additional","affiliation":[{"name":"Clinical Assay Unit, May & Baker Ltd , Dagenham, Essex RM10 7XS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M I","family":"Cawley","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Southampton General Hospital , Southampton S09 4XY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C M","family":"Kaye","sequence":"additional","affiliation":[{"name":"Clinical Assay Unit, May & Baker Ltd , Dagenham, Essex RM10 7XS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J E","family":"Holt","sequence":"additional","affiliation":[{"name":"Clinical Assay Unit, May & Baker Ltd , Dagenham, Essex RM10 7XS"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1982,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000237958","article-title":"Pharmacokinetics of metronidazole in pregnant women","volume":"27","author":"AMON, I.; AMON, K.; FRANKE, G.; MOHR, C.","year":"1981","unstructured":"AMON, I., AMON, K., FRANKE, G. & MOHR, C. 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(1974) Clindamycin and pseudomembranous colitis. Lancet, i, 172.","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1365-2125.1980.tb05856.x","article-title":"A rapid and specific semi-micro method involving high-pressure liquid chromatography for the assay of metronidazole in plasma, saliva, serum, urine and whole blood","volume":"9","author":"KAYE, C.M.; SANKEY, M.G.; THOMAS, L.A.","year":"1980","unstructured":"KAYE, C.M., SANKEY, M.G. & THOMAS, L.A. (1980) A rapid and specific semi-micro method involving high-pressure liquid chromatography for the assay of metronidazole in plasma, saliva, serum, urine and whole blood. 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(1966) Acute septic arthritis complicating rheumatoid arthritis. Journal of the American Medical Association, 196, 517.","journal-title":"Journal of the American Medical Association"},{"key":"ref_25","first-page":"175","article-title":"Diagnostic criteria for the rheumatoid arthritis","volume":"9","author":"ROPES, M.W.; BENNETT, G.A.; COBB, S.; JACOX, R.F.; JESSAR, R.A.","year":"1958","unstructured":"ROPES, M.W., BENNETT, G.A., COBB, S., JACOX, R.F. & JESSAR, R.A. (1958) Diagnostic criteria for the rheumatoid arthritis. Bulletin of Rheumatic Diseases, 9, 175.","journal-title":"Bulletin of Rheumatic Diseases"},{"key":"ref_26","article-title":"Concentrations of some antibiotics in synovial fluid after oral administration, with special reference to antistaphylococcal activity","author":"SATTAR, M.A.; BARRETT, S.P.; CAWLEY, M.I.D.","year":"(198-)","unstructured":"SATTAR, M.A., BARRETT, S.P. & CAWLEY, M.I.D. (198-) Concentrations of some antibiotics in synovial fluid after oral administration, with special reference to antistaphylococcal activity. Annals of Rheumatic Diseases, (in press).","journal-title":"Annals of Rheumatic Diseases"},{"key":"ref_27","first-page":"19","article-title":"Anaerobic bacteria in central nervous system infections","volume":"57","author":"SWARTZ, M.N.","year":"1970","unstructured":"SWARTZ, M.N. (1970) Anaerobic bacteria in central nervous system infections. Journal of the Florida Medical Association, 57, 19.","journal-title":"Journal of the Florida Medical Association"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1128\/AAC.7.5.672","article-title":"Treatment of anaerobic infections with metronidazole","volume":"7","author":"TALLY, F.P.; SUTTER, V.L.; FINEGOLD, S.M.","year":"1975","unstructured":"TALLY, F.P., SUTTER, V.L. & FINEGOLD, S.M. (1975) Treatment of anaerobic infections with metronidazole. 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