{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T09:16:50Z","timestamp":1697879810357},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"678","license":[{"start":{"date-parts":[[1982,4,1]],"date-time":"1982-04-01T00:00:00Z","timestamp":386467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Theophylline choline 600 mg was given as a single oral dose to nine patients in chronic left ventricular failure due to myocardial dysfunction. Cardiac output, left ventricular filling pressure (LVFP) and right atrial pressure (RAP) were measured with a pulmonary artery thermodilution catheter for the following 3 hr. Continuous recordings of cardiac rhythm were made throughout the study. Mean cardiac index increased from 1\u00b775 (\u00b10\u00b714 s.e. mean) to 2\u00b704 (\u00b10\u00b711) 1\/min\/m2 (P&amp;lt;0\u00b702), mean LVFP fell from 27 (\u00b12\u00b74) to 22 (\u00b11\u00b75) mmHg (P&amp;lt;0\u00b701), mean RAP fell from 5 (\u00b11\u00b73) to 3 (\u00b12\u00b70) mmHg (P&amp;lt;0\u00b705) and mean systemic arterial pressure rose from 80 (\u00b13) to 86 (\u00b13\u00b75) mmHg (P&amp;lt;0\u00b705). There were no significant changes in heart rate or systemic vascular resistance; thus the increase in cardiac output was probably due to a positive inotropic effect. Side effects were seen in two patients, both of whom proved to have toxic plasma theophylline concentrations.<\/jats:p>\n               <jats:p>This study demonstrated a beneficial acute haemodynamic effect of oral theophylline in chronic cardiac failure.<\/jats:p>","DOI":"10.1136\/pgmj.58.678.216","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"216-221","source":"Crossref","is-referenced-by-count":2,"title":["Oral theophylline in chronic heart failure"],"prefix":"10.1093","volume":"58","author":[{"given":"S","family":"Al-Damluji","sequence":"first","affiliation":[{"name":"Department of Cardiology , St Bartholomew\u2019s Hospital, London E.C.1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Cardiology , St Bartholomew\u2019s Hospital, London E.C.1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A J","family":"Spurrell","sequence":"additional","affiliation":[{"name":"Department of Cardiology , St Bartholomew\u2019s Hospital, London E.C.1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A W","family":"Nathan","sequence":"additional","affiliation":[{"name":"Department of Cardiology , St Bartholomew\u2019s Hospital, London E.C.1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S O","family":"Banim","sequence":"additional","affiliation":[{"name":"Department of Cardiology , St Bartholomew\u2019s Hospital, London E.C.1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Camm","sequence":"additional","affiliation":[{"name":"Department of Cardiology , St Bartholomew\u2019s Hospital, London E.C.1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1982,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1476-5381.1974.tb09709.x","article-title":"Relationship between theophylline uptake and inotropic effect in the guinea-pig heart","volume":"52","author":"BELLEMANN, P.; SCHOLZ, H.","year":"1974","unstructured":"BELLEMANN, P. & SCHOLZ, H. (1974) Relationship between theophylline uptake and inotropic effect in the guinea-pig heart. British Journal of Pharmacology, 52, 265.","journal-title":"British Journal of Pharmacology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1476-5381.1975.tb07412.x","article-title":"Dissociation of theophylline uptake and inotropic effect in myocardial tissue: influence of temperature, pH and calcium","volume":"54","author":"BELLEMAN, P.; SCHOLZ, H.","year":"1975","unstructured":"BELLEMAN, P. & SCHOLZ, H. (1975) Dissociation of theophylline uptake and inotropic effect in myocardial tissue: influence of temperature, pH and calcium. British Journal of Pharmacology, 54, 75.","journal-title":"British Journal of Pharmacology"},{"key":"ref_3","first-page":"303","article-title":"CRITERIA COMMITTEE OF THE NEW","volume":"44","author":"FITCHET, Boston","year":"1964","unstructured":"CRITERIA COMMITTEE OF THE NEW YORK HEART ASSOCIATION, INC. (1964) Diseases of the Heart and Blood Vessels (Nomenclature and Criteria for Diagnosis), 6th edn, Little, Brown & Company, Boston. FITCHET, D.H., MARIN NETO, J.A., OAKLEY, C.M. & GOODWIN, J.F. (1979) Hydralazine in the management of left ventricular failure. American Journal of Cardiology, 44, 303.","edition":"6th edn","journal-title":"Diseases of the Heart and Blood Vessels (Nomenclature and Criteria for Diagnosis; American Journal of Cardiology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0002-9149(72)90635-2","article-title":"Measurement of blood flow by thermodilution","volume":"29","author":"GANZ, W.; SWAN, H.J.C.","year":"1972","unstructured":"GANZ, W. & SWAN, H.J.C. (1972) Measurement of blood flow by thermodilution. American Journal of Cardiology, 29, 241.","journal-title":"American Journal of Cardiology"},{"key":"ref_5","first-page":"125","article-title":"The circulatory action of theophylline ethylene diamine","volume":"6","author":"HOWARTH, S.; MCMICHAEL, J.; SHARPEY-SCHAFER, E.P.","year":"1947","unstructured":"HOWARTH, S., MCMICHAEL, J. & SHARPEY-SCHAFER, E.P. (1947) The circulatory action of theophylline ethylene diamine. Clinical Science, 6, 125.","journal-title":"Clinical Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1161\/01.CIR.42.1.75","article-title":"Evaluation of pulmonary arterial end-diastolic pressure as an indirect estimate of left atrial mean pressure","volume":"42","author":"JENKINS, B.S.; BRADLEY, R.D.; BRANTHWAITE, M.A.","year":"1970","unstructured":"JENKINS, B.S., BRADLEY, R.D. & BRANTHWAITE, M.A. (1970) Evaluation of pulmonary arterial end-diastolic pressure as an indirect estimate of left atrial mean pressure. 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(1968) Effects of aminophylline on the pulmonary circulation and left ventricular performance in patients with valvular heart disease. Circulation, 37, 361.","journal-title":"Circulation"},{"key":"ref_11","first-page":"241","article-title":"A re-evaluation of parenteral aminophylline","volume":"108","author":"NICHOLSON, D.P.; CHICK, T.W.","year":"1973","unstructured":"NICHOLSON, D.P. & CHICK, T.W. (1973) A re-evaluation of parenteral aminophylline. American Review of Respiratory Disease, 108, 241.","journal-title":"American Review of Respiratory Disease"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0002-9149(66)90357-2","article-title":"Hemodynamic effects of aminophylline in heart failure","volume":"17","author":"PARKER, J.O.; KELLY, G.; WEST, R.O.","year":"1966","unstructured":"PARKER, J.O., KELLY, G. & WEST, R.O. (1966) Hemodynamic effects of aminophylline in heart failure. 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