{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T07:50:43Z","timestamp":1695282643791},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"679","license":[{"start":{"date-parts":[[1982,5,1]],"date-time":"1982-05-01T00:00:00Z","timestamp":389059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 49-year-old woman presented with a one month history of headaches, loss of libido and galactorrhoea. She had been taking metoclopramide for the previous 3 months for reflux oesophagitis. She was found to have substantially elevated serum prolactin levels and a pituitary adenoma, which have not been previously described in a patient taking metoclopramide. The drug was stopped and the serum prolactin level fell progressively to normal with resolution of symptoms over 4 months. This suggested that contrary to our original impression that she had a prolactin-secreting pituitary adenoma which had been stimulated by metoclopramide, she had metoclopramide-induced hyperprolactinaemia and an incidental pituitary tumour.<\/jats:p>","DOI":"10.1136\/pgmj.58.679.314","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"314-315","source":"Crossref","is-referenced-by-count":4,"title":["Galactorrhoea, hyperprolactinaemia, and pituitary adenoma presenting during metoclopramide therapy"],"prefix":"10.1093","volume":"58","author":[{"given":"B T","family":"Cooper","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Bristol and Bristol Royal Infirmary , Bristol BS2 8HW"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Mountford","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Bristol and Bristol Royal Infirmary , Bristol BS2 8HW"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"McKee","sequence":"additional","affiliation":[{"name":"Regional Drug Information Centre Bristol Royal Infirmary , Bristol BS2 8HW"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1982,5,1]]},"reference":[{"key":"ref_1","first-page":"1155","article-title":"Tests of prolactin secretion in diagnosis of prolactinomas","volume":"i,","author":"COWDEN, E.A.; RATCLIFFE, J.G.; THOMSON, J.A.; MCPHERSON, P.; DOYLE, D.; TEASDALE, G.M.","year":"1979","unstructured":"COWDEN, E.A., RATCLIFFE, J.G., THOMSON, J.A., MCPHERSON, P., DOYLE, D. & TEASDALE, G.M. (1979) Tests of prolactin secretion in diagnosis of prolactinomas. Lancet, i, 1155.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/bmj.2.5921.729","article-title":"Metoclopramide and prolactin","volume":"2","author":"MCNEILLY, A.S.; THORNER, M.O.; VOLANS, G.; BESSER, G.M.","year":"1974","unstructured":"MCNEILLY, A.S., THORNER, M.O., VOLANS, G. & BESSER, G.M. (1974) Metoclopramide and prolactin. British Medical Journal, 2, 729.","journal-title":"British Medical Journal"},{"issue":"4","key":"ref_3","first-page":"77","article-title":"Metoclopramide; side effects and safety","volume":"49","author":"ROBINSON, O.P.W.","year":"1973","unstructured":"ROBINSON, O.P.W. (1973) Metoclopramide; side effects and safety. Postgraduate Medical Journal, 49 (suppl. 4), 77.","journal-title":"Postgraduate Medical Journal"},{"key":"ref_4","first-page":"1019","article-title":"Pathogenesis of prolactin secreting adenomas","volume":"ii,","author":"SHERMAN, B.M.; HARRIS, C.E.; SCHLECHTE, J.; DUELLO, T.M.; HALMI, N.S.; GILDER, V.A.N.; I., C.H.A.P.T.E.R.; K., F.; GRASSNER, D.K.","year":"1978","unstructured":"SHERMAN, B.M., HARRIS, C.E., SCHLECHTE, J., DUELLO, T.M., HALMI, N.S., VAN GILDER, I., CHAPTER, F.K. & GRASSNER, D.K. (1978) Pathogenesis of prolactin secreting adenomas. Lancet, ii, 1019.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","DOI":"10.1016\/S0300-595X(77)80064-9","article-title":"Prolactin","author":"THORNER, M.O.","year":"1977","unstructured":"THORNER, M.O. (1977) Prolactin. Clinics in Endocrinology, 6, 201.","journal-title":"Clinics in Endocrinology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2265.1979.tb01357.x","article-title":"The effects of dopamine, bromocriptine, lergotrile and metoclopramide on prolactin release from continually perfused columns of isolated rat pituitary cells","volume":"10","author":"YEO, T.; THORNER, M.O.; JONES, A.; LOWRY, P.J.; BESSER, G.M.","year":"1979","unstructured":"YEO, T., THORNER, M.O., JONES, A., LOWRY, P.J. & BESSER, G.M. (1979) The effects of dopamine, bromocriptine, lergotrile and metoclopramide on prolactin release from continually perfused columns of isolated rat pituitary cells. Clinical Endocrinology, 10, 123.","journal-title":"Clinical Endocrinology"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/58\/679\/314\/50216695\/postgradmedj-58-314.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/58\/679\/314\/50216695\/postgradmedj-58-314.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T18:47:59Z","timestamp":1683658079000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/58\/679\/314\/7050133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,5,1]]},"references-count":6,"journal-issue":{"issue":"679","published-online":{"date-parts":[[1982,5,1]]},"published-print":{"date-parts":[[1982,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.58.679.314","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1982,5]]},"published":{"date-parts":[[1982,5,1]]}}}