{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T10:40:11Z","timestamp":1698144011903},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"680","license":[{"start":{"date-parts":[[1982,6,1]],"date-time":"1982-06-01T00:00:00Z","timestamp":391737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Primary mixed cryoglobulinaemia was diagnosed in a 65-year-old woman and confirmed on post-mortem examination. The patient had the classical findings of purpura, arthralgia, renal failure, mixed cryoglobulins in the serum and rheumatoid factor activity. The patient presented with haemolytic anaemia and later developed rectal bleeding, but the most prominent feature was an acute psychosis with electroencephalographic changes, that was attributed to the disease and responded well to corticosteroids. Primary mixed cryoglobulinaemia should be included in the differential diagnosis of central nervous system involvement in systemic connective tissue diseases. This complication should not be missed since it seems to respond well to corticosteroids and\/or to plasmapheresis if diagnosed in time.<\/jats:p>","DOI":"10.1136\/pgmj.58.680.359","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"359-361","source":"Crossref","is-referenced-by-count":4,"title":["Cerebral involvement in primary mixed cryoglobulinaemia"],"prefix":"10.1093","volume":"58","author":[{"given":"Amos","family":"Pines","sequence":"first","affiliation":[{"name":"Department of Medicine F, The Sheba Medical Center (Affiliated to Tel-Aviv University Medical School) , 52621 Tel-Hashomer , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehud","family":"Goldhammer","sequence":"additional","affiliation":[{"name":"Department of Medicine F, The Sheba Medical Center (Affiliated to Tel-Aviv University Medical School) , 52621 Tel-Hashomer , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Kaplinsky","sequence":"additional","affiliation":[{"name":"Department of Medicine F, The Sheba Medical Center (Affiliated to Tel-Aviv University Medical School) , 52621 Tel-Hashomer , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto","family":"Frankl","sequence":"additional","affiliation":[{"name":"Department of Medicine F, The Sheba Medical Center (Affiliated to Tel-Aviv University Medical School) , 52621 Tel-Hashomer , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1982,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1537-2995.1980.20280169957.x","article-title":"Use of plasmapheresis and partial plasma exchange in the management of patients with cryoglobulinemia","volume":"20","author":"BERKMAN, E.M.; ORLIN, J.B.","year":"1980","unstructured":"BERKMAN, E.M. & ORLIN, J.B. (1980) Use of plasmapheresis and partial plasma exchange in the management of patients with cryoglobulinemia. Transfusion, 20, 171.","journal-title":"Transfusion"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0002-9343(74)90852-3","article-title":"Biologic and clinical significance of cryoglobulins. A report of 86 cases","volume":"57","author":"BROUET, J.C.; CLAUVEL, J.P.; DANON, F.; KLEIN, M.; SELIGMANN, M.","year":"1974","unstructured":"BROUET, J.C., CLAUVEL, J.P., DANON, F., KLEIN, M. & SELIGMANN, M. (1974) Biologic and clinical significance of cryoglobulins. A report of 86 cases. American Journal of Medicine, 57, 775.","journal-title":"American Journal of Medicine"},{"key":"ref_3","first-page":"677","article-title":"Effect of vigorous therapy on 5 patients with mixed cryoglobulinemia with renal and neurological involvement","volume":"23","author":"GETTNER, D.; KOHN, R.; FRANKLIN, E.C.","year":"1980","unstructured":"GETTNER, D., KOHN, R. & FRANKLIN, E.C. (1980) Effect of vigorous therapy on 5 patients with mixed cryoglobulinemia with renal and neurological involvement. Arthritis and Rheumatism, 23, 677.","journal-title":"Arthritis and Rheumatism"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0002-9343(80)90390-3","article-title":"Mixed cryoglobulinemia: clinical aspects and long term follow up of 40 patients","volume":"69","author":"GOREVIC, P.D.; KASSAB, H.J.; LEVO, Y.; KOHN, R.; MELZER, M.; PROSE, P.; FRANKLIN, E.C.","year":"1980","unstructured":"GOREVIC, P.D., KASSAB, H.J., LEVO, Y., KOHN, R., MELZER, M., PROSE, P. & FRANKLIN, E.C. (1980) Mixed cryoglobulinemia: clinical aspects and long term follow up of 40 patients. American Journal of Medicine, 69, 287.","journal-title":"American Journal of Medicine"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0090-1229(78)90028-4","article-title":"Binding of circulating immune complexes to human peripheral blood lymphocytes: effect of complement","volume":"10","author":"KAMMER, G.M.; SCHOR, P.","year":"1978","unstructured":"KAMMER, G.M. & SCHOR, P. (1978) Binding of circulating immune complexes to human peripheral blood lymphocytes: effect of complement. Clinical Immunology and Immunopathology, 10, 202.","journal-title":"Clinical Immunology and Immunopathology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1056\/NEJM197706302962605","article-title":"Association between hepatitis B virus and essential mixed cryoglobulinemia","volume":"296","author":"LEVO, Y.; GOREVIC, P.D.; KASSAB, H.J.; ZUCKER-FRANKLIN, D.; FRANKLIN, E.C.","year":"1977","unstructured":"LEVO, Y., GOREVIC, P.D., KASSAB, H.J., ZUCKER-FRANKLIN, D. & FRANKLIN, E.C. (1977) Association between hepatitis B virus and essential mixed cryoglobulinemia. New England Journal of Medicine, 296, 1501.","journal-title":"New England Journal of Medicine"},{"key":"ref_7","first-page":"677","article-title":"Gastrointestinal involvement in leucocytoclastic vasculitis and polyarthritis nodosa","volume":"7","author":"LOPEZ, L.R.; SCHOCKET, R.E.; STANFORD, R.E.; CLAMAN, H.N.; KOHLER, P.F.","year":"1980","unstructured":"LOPEZ, L.R., SCHOCKET, R.E., STANFORD, R.E., CLAMAN, H.N. & KOHLER, P.F. (1980) Gastrointestinal involvement in leucocytoclastic vasculitis and polyarthritis nodosa. Journal of Rheumatology, 7, 677.","journal-title":"Journal of Rheumatology"},{"key":"ref_8","first-page":"383","article-title":"Purpura arthralgia and IgG-IgM cryoglobulinemia with rheumatoid factor activity. Response to cyclophosphamide. Annals o'","volume":"74","author":"MATHISON, D.A.; CONDEMI, J.J.; LEDDY, J.P.; CALLERAME, M.I.; PAUNER, B.J.; VAUGHAN, J.H.","year":"1971","unstructured":"MATHISON, D.A., CONDEMI, J.J., LEDDY, J.P., CALLERAME, M.I., PAUNER, B.J. & VAUGHAN, J.H. (1971) Purpura arthralgia and IgG-IgM cryoglobulinemia with rheumatoid factor activity. Response to cyclophosphamide. Annals o' Internal Medicine, 74, 383.","journal-title":"Internal Medicine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/0002-9343(66)90199-9","article-title":"Cryoglobulinemia-a study of twenty-nine patients. I. IgG and IgM cryoglobulin and factors affecting cryoprecipitability","volume":"40","author":"MELZER, M.; FRANKLIN, E.C.","year":"1966","unstructured":"MELZER, M. & FRANKLIN, E.C. (1966) Cryoglobulinemia-a study of twenty-nine patients. I. IgG and IgM cryoglobulin and factors affecting cryoprecipitability. American Journal of Medicine, 40, 828.","journal-title":"American Journal of Medicine"},{"key":"ref_10","article-title":"Renal disease in essential mixed cryoglobulinemia-long term follow up of 44 patients","volume":"50","author":"TARANTINO, A.; VECCHI, D.E.; A., M.O.N.T.A.G.N.I.N.O.; G., I.M.B.A.S.C.I.A.T.I.; E., M.I.H.A.T.S.C.H.; J., M.; ZOLLINGER, H.U.; BELGIOJOSO, B.A.R.B.I.A.N.O.D.I.; G., B.U.S.N.A.C.H.; G.; PONTICELLI, C.","year":"1981","unstructured":"TARANTINO, A., DE VECCHI, A., MONTAGNINO, G., IMBASCIATI, E., MIHATSCH, M.J., ZOLLINGER, H.U., BARBIANO DI BELGIOJOSO, G., BUSNACH, G. & PONTICELLI, C. (1981) Renal disease in essential mixed cryoglobulinemia-long term follow up of 44 patients. Quarterly Journal of Medicine, 50, 197.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_11","first-page":"357","article-title":"Vasculitis in connective tissue diseases","volume":"6","author":"WEISMAN, M.H.; ZVAIFLER, N.J.","year":"1980","unstructured":"WEISMAN, M.H. & ZVAIFLER, N.J. (1980) Vasculitis in connective tissue diseases. Clinics in Rheumatic Diseases, 6, 357.","journal-title":"Clinics in Rheumatic Diseases"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/58\/680\/359\/50216951\/postgradmedj-58-359.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/58\/680\/359\/50216951\/postgradmedj-58-359.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T23:01:24Z","timestamp":1683673284000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/58\/680\/359\/7050182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,6,1]]},"references-count":11,"journal-issue":{"issue":"680","published-online":{"date-parts":[[1982,6,1]]},"published-print":{"date-parts":[[1982,6,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.58.680.359","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1982,6]]},"published":{"date-parts":[[1982,6,1]]}}}