{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:21Z","timestamp":1761058881432},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"681","license":[{"start":{"date-parts":[[1982,7,1]],"date-time":"1982-07-01T00:00:00Z","timestamp":394329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,7,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Neurological and psychiatric side effects of cimetidine are reviewed in 47 cases from the literature, and 3 further cases are described. Confusion, psychomotor restlessness, hallucinations and disorientation, stupor and coma were the main features; some had convulsions and a few exhibited focal neurological deficits or neuropathies. The signs appeared within 2 days in almost half of the patients, and remitted in most within 2-3 days. Predisposing factors, of which more than one may be present, are advanced age, hepatic or renal dysfunction, or severe underlying disease. The 3 cases described were all old, one had cirrhosis with bleeding oesophageal varices, and one had renal failure with nephrotic syndrome and amyloidosis.<\/jats:p>\n               <jats:p>In view of the increasingly wide use of cimetidine, conditions in which there is decreased metabolic breakdown, or excretion, or predisposition to increased brain levels should prompt careful follow-up, and possibly a lower dosage regimen, especially in elderly patients.<\/jats:p>","DOI":"10.1136\/pgmj.58.681.415","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"415-418","source":"Crossref","is-referenced-by-count":18,"title":["Neurological and psychiatric side effects of cimetidine\u2014report of 3 cases with review of the literature"],"prefix":"10.1093","volume":"58","author":[{"given":"M","family":"Sonnenblick","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, Shaare Zedek Medical Center , Jerusalem , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Rosin","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Shaare Zedek Medical Center , Jerusalem , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Weissberg","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Shaare Zedek Medical Center , Jerusalem , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1982,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1176\/ajp.137.9.1112","article-title":"Cimetidine toxicity manifested as paranoia and hallucinations","volume":"137","author":"ADLER, L.E.; SADJA, L.; WILETS, G.","year":"1980","unstructured":"ADLER, L.E., SADJA, L. & WILETS, G. (1980) Cimetidine toxicity manifested as paranoia and hallucinations. American Journal of Psychiatry, 137, 1112.","journal-title":"American Journal of Psychiatry"},{"key":"ref_2","article-title":"Cimetidine and mental confusion (letter)","volume":"512","author":"AELANEY, J.; RAVEY, M.","year":"1977","unstructured":"AELANEY, J. & RAVEY, M. (1977) Cimetidine and mental confusion (letter). Lancet, ii, 512.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1001\/jama.1978.03290030032013","article-title":"Cimetidine and visual hallucinations (letter)","volume":"240","author":"AGARWAL, S.K.","year":"1978","unstructured":"AGARWAL, S.K. (1978) Cimetidine and visual hallucinations (letter). 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