{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:24:53Z","timestamp":1760783093299},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"682","license":[{"start":{"date-parts":[[1982,8,1]],"date-time":"1982-08-01T00:00:00Z","timestamp":397008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,8,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The clinical and biochemical features of a patient with flushing and severe diarrhoea due to the carcinoid syndrome are described. The patient had a paradoxical response to the tryptophan hydroxylase inhibitor parachlorophenylalanine with complete abolition of flushing and no effect on the diarrhoea. Treatment with this drug was limited by adverse effects.<\/jats:p>","DOI":"10.1136\/pgmj.58.682.493","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"493-495","source":"Crossref","is-referenced-by-count":6,"title":["Clinical and biochemical effects of parachlorophenylalanine in a patient with the carcinoid syndrome"],"prefix":"10.1093","volume":"58","author":[{"given":"N D S","family":"Bax","sequence":"first","affiliation":[{"name":"University Department of Pharmacology and Therapeutics, Royal Hallamshire Hospital , Glossop Road, Sheffield S10 2JF"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H F","family":"Woods","sequence":"additional","affiliation":[{"name":"University Department of Pharmacology and Therapeutics, Royal Hallamshire Hospital , Glossop Road, Sheffield S10 2JF"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J M","family":"Boulton","sequence":"additional","affiliation":[{"name":"University Department of Pharmacology and Therapeutics, Royal Hallamshire Hospital , Glossop Road, Sheffield S10 2JF"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A R","family":"Green","sequence":"additional","affiliation":[{"name":"MRC Clinical Pharmacology Unit, University Department of Clinical Pharmacology, Radcliffe Infirmary , Oxford OX2 6HE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1982,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0002-9343(61)90072-9","article-title":"Carcinoid syndrome associated with hypersertoninaemia and normal 5-hydroxyindole acid excretion","volume":"30","author":"DAvis, R.B.; ROSENBERG, J.C.","year":"1961","unstructured":"DAvis, R.B. & ROSENBERG, J.C. (1961) Carcinoid syndrome associated with hypersertoninaemia and normal 5-hydroxyindole acid excretion. American Journal of Medicine, 30, 167.","journal-title":"American Journal of Medicine"},{"key":"ref_2","first-page":"160","article-title":"The determination of tryptophan in plasma, liver and urine","volume":"69","author":"DENCKLA, W.D.; DEWEY, H.K.","year":"1967","unstructured":"DENCKLA, W.D. & DEWEY, H.K. (1967) The determination of tryptophan in plasma, liver and urine. Journal of Laboratory and Clinical Medicine, 69, 160.","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1056\/NEJM196711232772101","article-title":"Inhibition of serotonin synthesis by para-chlorophenylalanine in patients with the carcinoid syndrome","volume":"277","author":"ENGELMAN, K.; W., L.O.V.E.N.B.E.R.G.; SJOERDSMA, A.","year":"1967","unstructured":"ENGELMAN, K., LOVENBERG. W. & SJOERDSMA, A. (1967) Inhibition of serotonin synthesis by para-chlorophenylalanine in patients with the carcinoid syndrome. New England Journal of Medicine, 277, 1103.","journal-title":"New England Journal of Medicine"},{"key":"ref_4","first-page":"77","article-title":"The Carcinoid Syndrome","author":"GRAHAME-SMITH, D.G.","year":"1972","unstructured":"GRAHAME-SMITH, D.G. (1972) The Carcinoid Syndrome. p. 77. The Whitefriars Press, London and Tonbridge."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1365-2125.1980.tb00516.x","article-title":"Metabolism of an oral tryptophan load. Effects of dose and pretreatment with tryptophan","volume":"10","author":"GREEN, A.R.; ARONSON, J.K.; CURZON, G.; WOODS, H.F.","year":"1980","unstructured":"GREEN, A.R., ARONSON, J.K., CURZON, G. & WOODS, H.F. (1980) Metabolism of an oral tryptophan load. Effects of dose and pretreatment with tryptophan. 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(1972) Mental and neuromuscular symptoms in tryptophan deficiency: Pellagra, carcinoidosis, phenylketonuria, Hartnup disease and disturbances of tryptophan metabolism induced by p-chlorophenylalanine, levodopa and a-methyldopa. Acta Psychiatrica Scandinavia, Suppl 237.","journal-title":"Acta Psychiatrica Scandinavia"},{"key":"ref_8","first-page":"117","article-title":"Carcinoid Tumours. A Clinicopathologic Study","author":"MARKS, C.","year":"1979","unstructured":"MARKS, C. (1979) Carcinoid Tumours. A Clinicopathologic Study. p. 117."},{"key":"ref_9","article-title":"Release of a kinin peptide in the carcinoid syndrome","volume":"514","author":"OATES, J.A.; MELMON, K.; SJOERDSMA, A.; GILLESPIE, L.; MASON, D.T.","year":"1964","unstructured":"OATES, J.A., MELMON, K., SJOERDSMA, A., GILLESPIE, L. & MASON, D.T. (1964). Release of a kinin peptide in the carcinoid syndrome. 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