{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:57:32Z","timestamp":1790089052824,"version":"4.0.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"683","license":[{"start":{"date-parts":[[1982,9,1]],"date-time":"1982-09-01T00:00:00Z","timestamp":399686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 20-year-old woman developed severe persistent vomiting early in pregnancy. In three months she lost 18 kg of body weight and showed the biochemical features of mild hepatic failure. Four days after starting intravenous dextrose and insulin, she developed short-term memory loss, confusion, ataxia, dysarthria, mild left upper motor neurone facial weakness and upbeat nystagmus. Thiamine was given and no further deterioration occurred. The vomiting persisted until intra-uterine fetal death. Thereafter, her medical, neurological and psychological problems gradually improved. The association of hyperemesis gravidarum, intravenous calorie load and Wernicke\u2019s encephalopathy is discussed.<\/jats:p>","DOI":"10.1136\/pgmj.58.683.558","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"558-559","source":"Crossref","is-referenced-by-count":31,"title":["Wernicke\u2019s encephalopathy in hyperemesis gravidarum"],"prefix":"10.1093","volume":"58","author":[{"given":"S","family":"Nightingale","sequence":"first","affiliation":[{"name":"Departments of Neurology and Obstetrics and Gynaecology, Royal Victoria Infirmary , Newcastle upon Tyne NE1 4LP"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P D","family":"Heath","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Obstetrics and Gynaecology, Royal Victoria Infirmary , Newcastle upon Tyne NE1 4LP"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bates","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Obstetrics and Gynaecology, Royal Victoria Infirmary , Newcastle upon Tyne NE1 4LP"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S L","family":"Barron","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Obstetrics and Gynaecology, Royal Victoria Infirmary , Newcastle upon Tyne NE1 4LP"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1982,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1056\/NEJM197712222972503","article-title":"Abnormality of a thiaminerequiring enzyme in patients with Wernicke-Korsakoff syndrome","volume":"297","author":"BLAss, J.P.; GIBSON, G.E.","year":"1977","unstructured":"BLAss, J.P. & GIBSON, G.E. (1977) Abnormality of a thiaminerequiring enzyme in patients with Wernicke-Korsakoff syndrome. New England Journal of Medicine, 297, 1367.","journal-title":"New England Journal of Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/path.1700480202","article-title":"Wernicke's encephalopathy (polioencephalitis haemorrhagica superior): its alcoholic and non-alcoholic incidence","volume":"48","author":"CAMPBELL, A.C.P.; BIGGART, J.H.","year":"1939","unstructured":"CAMPBELL, A.C.P. & BIGGART, J.H. (1939) Wernicke's encephalopathy (polioencephalitis haemorrhagica superior): its alcoholic and non-alcoholic incidence. Journal of Pathology and Bacteriology, 48, 245.","journal-title":"Journal of Pathology and Bacteriology"},{"key":"ref_3","first-page":"712","article-title":"In: Cecil-Loeb Textbook of Medicine","author":"DREYFUS, P.M.","year":"1979","unstructured":"DREYFUS, P.M. (1979) In: Cecil-Loeb Textbook of Medicine (ed by Beeson, P.B., McDermott, W. & Wyngaarden, J.B.), p. 712."},{"key":"ref_4","volume":"781","author":"EBELS, E.J.","year":"1978","unstructured":"EBELS, E.J. (1978) Letter. Lancet, i, 781.","journal-title":"Letter. Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/jnnp.42.3.226","article-title":"Wernicke's encephalopathy: a more common disease than realized. A neuropathological study of 51 patients","volume":"42","author":"HARPER, C.","year":"1979","unstructured":"HARPER, C. (1979) Wernicke's encephalopathy: a more common disease than realized. A neuropathological study of 51 patients. Journal of Neurology, Neurosurgery and Psychiatry, 42, 226.","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1471-0528.1939.tb05368.x","article-title":"The pathology of hyperemesis gravidarum and vomiting of late pregnancy","volume":"46","author":"SHEEHAN, H.L.","year":"1939","unstructured":"SHEEHAN, H.L. (1939) The pathology of hyperemesis gravidarum and vomiting of late pregnancy. Journal of Obstetrics and Gynaecology of the British Commonwealth, 46, 685.","journal-title":"Journal of Obstetrics and Gynaecology of the British Commonwealth"},{"key":"ref_7","article-title":"The WernickeKorsakoff Syndrome","volume":"400","author":"VICTOR, M.; ADAMS, R.D.; COLLINS, G.H.","year":"1971","unstructured":"VICTOR, M., ADAMS, R.D. & COLLINS, G.H. (1971) The WernickeKorsakoff Syndrome. Blackwell Scientific Publications, Oxford. WALLIS, W.E., WILLOUGHBY, E. & BAKER, P. (1978) Coma in the Wernicke-Korsakoff syndrome. Lancet, i, 400.","journal-title":"Lancet; Coma in the Wernicke-Korsakoff syndrome"},{"key":"ref_8","article-title":"Lehrbuck","author":"WERNICKE, C.","year":"1881","unstructured":"WERNICKE, C. (1881) Lehrbuck der Gihirnkrankheiten fur Arzte und"},{"key":"ref_9","first-page":"229","volume":"2","author":"Studieren, Vol","unstructured":"Studieren, Vol. 2, p. 229. Theodor Fischer, Kassel."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/58\/683\/558\/49289933\/postgradmedj-58-558.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/58\/683\/558\/49289933\/postgradmedj-58-558.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T13:27:28Z","timestamp":1681997248000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/58\/683\/558\/7050077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,9,1]]},"references-count":9,"journal-issue":{"issue":"683","published-online":{"date-parts":[[1982,9,1]]},"published-print":{"date-parts":[[1982,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.58.683.558","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1982,9]]},"published":{"date-parts":[[1982,9,1]]}}}