{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:55:10Z","timestamp":1760982910285},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"694","license":[{"start":{"date-parts":[[1983,8,1]],"date-time":"1983-08-01T00:00:00Z","timestamp":428544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1983,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We present an unusual case of extreme metabolic alkalosis resulting from severe hypokalaemia caused by unmonitored fludrocortisone therapy. Biochemical aspects of the disorder are discussed, as is the successful treatment with diuretics and potassium replacement. Some dangers of this therapy and necessary precautions are emphasized.<\/jats:p>","DOI":"10.1136\/pgmj.59.694.506","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"506-507","source":"Crossref","is-referenced-by-count":8,"title":["Extreme metabolic alkalosis with fludrocortisone therapy"],"prefix":"10.1093","volume":"59","author":[{"given":"A","family":"Burns","sequence":"first","affiliation":[{"name":"Chest Unit, Inverclyde Royal Hospital , Greenock PA16 0XN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T M","family":"Brown","sequence":"additional","affiliation":[{"name":"Chest Unit, Inverclyde Royal Hospital , Greenock PA16 0XN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Semple","sequence":"additional","affiliation":[{"name":"Chest Unit, Inverclyde Royal Hospital , Greenock PA16 0XN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1983,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0025-7125(16)31528-0","article-title":"Mixed acid base disturbances","volume":"65","author":"BIA, M.; THIER, S.O.","year":"1981","unstructured":"BIA, M. & THIER, S.O. (1981) Mixed acid base disturbances. Medical Clinics of North America, 65, 347.","journal-title":"Medical Clinics of North America"},{"key":"ref_2","first-page":"113","article-title":"The relationship between arterial PCO2 and hydrogen ion concentration in chronic metabolic acidosis and alkalosis","volume":"46","author":"BONE, J.M.; COWIE, J.; LAMBIE, A.N.N.E.T.; ROBSON, J.S.","year":"1974","unstructured":"BONE, J.M., COWIE, J., LAMBIE, ANNE T. & ROBSON, J.S. (1974) The relationship between arterial PCO2 and hydrogen ion concentration in chronic metabolic acidosis and alkalosis. Clinical Science and Molecular Medicine, 46, 113.","journal-title":"Clinical Science and Molecular Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1136\/bmj.1.6014.872","article-title":"Therapeutic experience with fludrocortisone in diabetic postural hypotension","volume":"1","author":"CAMPBELL, I.W.; EWING, D.J.; CLARKE, B.F.","year":"1976","unstructured":"CAMPBELL, I.W., EWING, D.J. & CLARKE, B.F. (1976) Therapeutic experience with fludrocortisone in diabetic postural hypotension. British Medical Journal, 1, 872.","journal-title":"British Medical Journal"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1056\/NEJM197907123010202","article-title":"Mineralocorticoid induced hypertension in patients with orthostatic hypotension","volume":"301","author":"CHOBANIAN, A.V.; VOLICER, L.; TIFFT, C.; GAVRAS, H.; LIANG, C.; FAXON, D.","year":"1979","unstructured":"CHOBANIAN, A.V., VOLICER, L., TIFFT, C., GAVRAS, H., LIANG, C. & FAXON, D. (1979) Mineralocorticoid induced hypertension in patients with orthostatic hypotension. New England Journal of Medicine, 301, 68.","journal-title":"New England Journal of Medicine"},{"key":"ref_5","first-page":"19","article-title":"Hypercapnia in metabolic alkalosis","volume":"76","author":"FULOP, M.","year":"1976","unstructured":"FULOP, M. (1976) Hypercapnia in metabolic alkalosis. New York State Journal of Medicine, 76, 19.","journal-title":"New York State Journal of Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1172\/JCI105708","article-title":"Respiratory adjustment to chronic metabolic alkalosis in man","volume":"47","author":"GOLDRING, R.M.; CANNON, P.J.; HEINEMANN, H.O.; FISHMAN, A.P.","year":"1968","unstructured":"GOLDRING, R.M., CANNON, P.J., HEINEMANN, H.O. & FISHMAN, A.P. (1968) Respiratory adjustment to chronic metabolic alkalosis in man. Journal of Clinical Investigation, 47, 188.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0002-9343(70)80021-3","article-title":"On the pathogenesis of metabolic alkalosis in hyperaldosteronism","volume":"49","author":"KASSIRER, J.P.; LONDON, A.M.; GOLDMAN, D.M.; SCHWARTZ, W.B.","year":"1970","unstructured":"KASSIRER, J.P., LONDON, A.M., GOLDMAN, D.M. & SCHWARTZ, W.B. (1970) On the pathogenesis of metabolic alkalosis in hyperaldosteronism. American Journal of Medicine, 49, 306.","journal-title":"American Journal of Medicine"},{"key":"ref_8","first-page":"584","article-title":"Committee on research into chronic bronchitis. Questionnaire on respiratory symptoms","volume":"28","author":"COUNCIL, M.E.D.I.C.A.L.R.E.S.E.A.R.C.H.","year":"1966","unstructured":"MEDICAL RESEARCH COUNCIL (1966) Committee on research into chronic bronchitis. Questionnaire on respiratory symptoms. Medical Research Councj, London. NICHOLLS, M.G., RAMSAY, L.E., BODDY, K., FRASER, R., MORTON, J.J. & ROBERTSON, J.I.S. (1979) Mineralocorticoid induced blood pressure, electrolyte and hormone changes and reversal with spironolactone in healthy men. Metabolism, 28, 584.","journal-title":"Metabolism; Mineralocorticoid induced blood pressure, electrolyte and hormone changes and reversal with spironolactone in healthy men"},{"key":"ref_9","first-page":"836","article-title":"Hypoxia and hypercapnia caused by respiratory compensation for metabolic alkalosis","volume":"107","author":"SHEAR, L.; BRANDMAN, I.S.","year":"1973","unstructured":"SHEAR, L. & BRANDMAN, I.S. (1973) Hypoxia and hypercapnia caused by respiratory compensation for metabolic alkalosis. American Review of Respiratory Disease, 107, 836.","journal-title":"American Review of Respiratory Disease"},{"key":"ref_10","first-page":"205","article-title":"The treatment of idiopathic orthostatic hypotension: a combined fludrocortisone and flurbiprofen regime","volume":"198","author":"WATT, S.J.; TOOKE, J.E.; PERKINS, C.M.","year":"1981","unstructured":"WATT, S.J., TOOKE, J.E. & PERKINS, C.M. (1981) The treatment of idiopathic orthostatic hypotension: a combined fludrocortisone and flurbiprofen regime. Quarterly Journal of Medicine, 198, 205.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_11","article-title":"Accepted","year":"1982","unstructured":"(Accepted 7 December 1982)"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/59\/694\/506\/50200829\/postgradmedj-59-506.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/59\/694\/506\/50200829\/postgradmedj-59-506.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T10:23:43Z","timestamp":1683282223000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/59\/694\/506\/7038845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,8,1]]},"references-count":11,"journal-issue":{"issue":"694","published-online":{"date-parts":[[1983,8,1]]},"published-print":{"date-parts":[[1983,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.59.694.506","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1983,8]]},"published":{"date-parts":[[1983,8,1]]}}}