{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:20:11Z","timestamp":1761862811360},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"698","license":[{"start":{"date-parts":[[1983,12,1]],"date-time":"1983-12-01T00:00:00Z","timestamp":439084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1983,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>To investigate whether HLA-A, -B, -C, and -DR alloantigen frequencies are different in diabetic patients with and without necrobiosis lipoidica diabeticorum we studied 37 insulin-dependent (Type I) diabetics, 15 with and 22 without necrobiosis, and 96 normal control subjects. Compared to controls Type I diabetics had increased frequencies of B8, CW3, and DR4 and decreased frequencies of DR5 and DR7. Diabetics with necrobiosis differed from diabetics without necrobiosis only in that HLA-A2 was significantly less frequent in patients with necrobiosis. It is suggested that the lack of major differences between patients with and without necrobiosis argues in favour of the role of metabolic and\/or vascular rather than genetic factors in the aetiology of necrobiosis.<\/jats:p>","DOI":"10.1136\/pgmj.59.698.759","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"759-762","source":"Crossref","is-referenced-by-count":8,"title":["HLA antigens and necrobiosis lipoidica diabeticorum\u2014a comparison between insulin-dependent diabetics with and without necrobiosis"],"prefix":"10.1093","volume":"59","author":[{"given":"Norman G","family":"Soler","sequence":"first","affiliation":[{"name":"Department of Medicine, Southern Illinois University School of Medicine , P.O. Box 3926, Springfield, Illinois 62708, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R","family":"McConnachie","sequence":"additional","affiliation":[{"name":"Department of Medicine, Southern Illinois University School of Medicine , P.O. Box 3926, Springfield, Illinois 62708, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1983,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2337\/diab.31.1.70","article-title":"Genetic and immunologic factors in microvascular disease in Type I insulin-dependent diabetes","volume":"31","author":"BODANSKY, H.H.; WOLF, E.; CUDWORTH, A.G.; DEAN, B.M.; NENEHAM, L.J.; BOTTAzzo, G.H.; MATTHEWS, J.A.; KURTZ, A.B.; KOHNER, E.M.","year":"1982","unstructured":"BODANSKY, H.H., WOLF, E., CUDWORTH, A.G., DEAN, B.M., NENEHAM, L.J., BOTTAzzo, G.H., MATTHEWS, J.A., KURTZ, A.B. & KOHNER, E.M. (1982) Genetic and immunologic factors in microvascular disease in Type I insulin-dependent diabetes. Diabetes, 31, 70.","journal-title":"Diabetes"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1056\/NEJM198106113042403","article-title":"Insulin-dependent diabetes mellitus: the initial lesion","volume":"304","author":"CAHILL, G.R.; McDEVITT, H.O.","year":"1981","unstructured":"CAHILL, G.R. & McDEVITT, H.O. (1981) Insulin-dependent diabetes mellitus: the initial lesion. New England Journal ofMedicine, 304, 1454.","journal-title":"New England Journal ofMedicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.2337\/diab.31.3.226","article-title":"Genetic susceptibility to the development of retinopathy in insulindependent diabetics","volume":"31","author":"DORNAN, T.L.; TING, A.; MCPHERSON, C.K.; PECKARD, C.O.; MANN, J.I.; TURNER, R.C.; MORRIS, P.J.","year":"1982","unstructured":"DORNAN, T.L., TING, A., MCPHERSON, C.K., PECKARD, C.O., MANN, J.I., TURNER, R.C. & MORRIS, P.J. (1982) Genetic susceptibility to the development of retinopathy in insulindependent diabetics. Diabetes, 31, 226.","journal-title":"Diabetes"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJM197805042981823","article-title":"Treatment of diabetic necrobiosis with aspirin and dipyridamole","volume":"298","author":"ELDON, A.; DIAZ, E.G.; NAPARSTEK, E.","year":"1978","unstructured":"ELDON, A., DIAZ, E.G. & NAPARSTEK, E. (1978) Treatment of diabetic necrobiosis with aspirin and dipyridamole. New England Journal of Medicine, 298, 1033.","journal-title":"New England Journal of Medicine"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"552","DOI":"10.2337\/diab.28.6.552","article-title":"HLA-D-related (DRW) antigens in juvenile diabetes mellitus","volume":"28","author":"FARID, N.R.; SAMPSON, L.; NOEL, P.; BARNARD, J.M.; DAVIS, A.J.; HILLMAN, D.A.","year":"1979","unstructured":"FARID, N.R., SAMPSON, L., NOEL, P., BARNARD, J.M., DAVIS, A.J. & HILLMAN, D.A. (1979) HLA-D-related (DRW) antigens in juvenile diabetes mellitus. Diabetes, 28, 552.","journal-title":"Diabetes"},{"key":"ref_6","first-page":"425","article-title":"Histocompatibility antigens in granuloma annulare: comparitive study of the generalized and localized type","volume":"98","year":"1978","unstructured":"FRIEDMAN-BIRNBAUM, R., HAIM, S., GIDEONE, 0. & BARZILAI, A. (1978) Histocompatibility antigens in granuloma annulare: comparitive study of the generalized and localized type. British Journal of Dermatology, 98, 425.","journal-title":"British Journal of Dermatology"},{"key":"ref_7","author":"HILDEBRAND, A.G.; MONTGOMERY, H.; RYNEARSON, E.H.","year":"1940","unstructured":"HILDEBRAND, A.G., MONTGOMERY, H. & RYNEARSON, E.H. (1940)"},{"issue":"6","key":"ref_8","first-page":"253","article-title":"HLA-DR typing in identical twins with insulin-dependent diabetes: differences between concordant and discordant pairs","volume":"2","author":"JOHNSTON, C.; PYKE, D.A.; CUDWORTH, A.G.; WOLF, E.","year":"1983","unstructured":"JOHNSTON, C., PYKE, D.A., CUDWORTH, A.G. & WOLF, E. (1983) HLA-DR typing in identical twins with insulin-dependent diabetes: differences between concordant and discordant pairs. 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Archives of Dermatology, 93, 272.","journal-title":"Archives of Dermatology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"736","DOI":"10.2337\/diab.26.8.736","article-title":"HLA antigens in Japanese patients with diabetes mellitus","volume":"26","author":"NAKAO, Y.; FUKUNISHI, T.; KoIDE, M.","year":"1977","unstructured":"NAKAO, Y., FUKUNISHI, T. & KoIDE, M. (1977) HLA antigens in Japanese patients with diabetes mellitus. Diabetes, 26, 736.","journal-title":"Diabetes"},{"issue":"2","key":"ref_15","first-page":"100","article-title":"HLA, insulin-dependent diabetes and sex","volume":"31","author":"ORCHARD, T.J.; EBERHARDT, M.; RABIN, B.; CAVENDER, D.","year":"1982","unstructured":"ORCHARD, T.J., EBERHARDT, M., RABIN, B. & CAVENDER, D. (1982) HLA, insulin-dependent diabetes and sex. 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(1979) Juvenile-onset diabetes: HLA-A, -B, -C, and -DR alloantigens. Diabetes, 28, 1.","journal-title":"Diabetes; DR alloantigens"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1001\/archderm.1977.01640120039004","article-title":"Necrobiosis lipoidica","volume":"113","author":"ULLMAN, S.; DAHL, M.V.","year":"1977","unstructured":"ULLMAN, S. & DAHL, M.V. (1977) Necrobiosis lipoidica. Archives of Dermatology, 113, 1671.","journal-title":"Archives of Dermatology"},{"key":"ref_20","author":"ZAR, G.H.","year":"1974","unstructured":"ZAR, G.H. (1974) In: Bio-statistical Analysis (Eds. W. D. McElvoy and C. P. Swanson), Prentice Hall, Englewood Cliff, New Jersey."},{"key":"ref_21","article-title":"Accepted","year":"1983","unstructured":"(Accepted 1 June 1983)"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/59\/698\/759\/50201198\/postgradmedj-59-759.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/59\/698\/759\/50201198\/postgradmedj-59-759.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T09:35:46Z","timestamp":1683279346000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/59\/698\/759\/7038755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,12,1]]},"references-count":21,"journal-issue":{"issue":"698","published-online":{"date-parts":[[1983,12,1]]},"published-print":{"date-parts":[[1983,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.59.698.759","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1983,12]]},"published":{"date-parts":[[1983,12,1]]}}}