{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:38:52Z","timestamp":1697175532696},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"699","license":[{"start":{"date-parts":[[1984,1,1]],"date-time":"1984-01-01T00:00:00Z","timestamp":441763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 21-year-old man presented with a 16-year history of recurrent pyrexial episodes and a 5-year history of gynaecomastia. Blood and urinary oestrogen levels were elevated and a mass was found in the upper pole of a retractile right testis.<\/jats:p>\n               <jats:p>After orchidectomy, oestrogen levels fell, gynaecomastia regressed and the pyrexial episodes ceased.<\/jats:p>\n               <jats:p>Histological examination of the right testis showed a benign Leydig cell tumour in the upper pole and a germinal cell carcinoma in situ in the remaining part of the testis. Thus a potentially lethal condition was detected at an early pre-malignant phase by virtue of a benign, endocrinologically active tumour. This would seem to be the first report of the co-existence of a Leydig cell tumour and germ cell carcinoma in the same testis.<\/jats:p>","DOI":"10.1136\/pgmj.60.699.66","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"66-69","source":"Crossref","is-referenced-by-count":2,"title":["Benign Leydig cell tumour and germ cell carcinoma in situ in a young man with gynaecomastia"],"prefix":"10.1093","volume":"60","author":[{"given":"R. S.","family":"Fink","sequence":"first","affiliation":[{"name":"Departments of Chemical Pathology, Medicine and Histopathology, Royal Free Hospital School of Medicine , London NW3 2QG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. S.","family":"Mann","sequence":"additional","affiliation":[{"name":"Departments of Chemical Pathology, Medicine and Histopathology, Royal Free Hospital School of Medicine , London NW3 2QG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Hopewell","sequence":"additional","affiliation":[{"name":"Departments of Chemical Pathology, Medicine and Histopathology, Royal Free Hospital School of Medicine , London NW3 2QG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Ginsburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1984,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1210\/jcem-53-6-1291","article-title":"Leydig cell tumour with gynaecomastia: hormonal effects of an oestrogen-producing tumour","volume":"53","author":"BERCOVICI, J.P.; TATER, D.; SLEMEN, K.; JEAN-FRANCOIS, C.; FLOCH, J.; LEROY, J.-P.","year":"1981","unstructured":"BERCOVICI, J.P., TATER, D., SLEMEN, K., JEAN-FRANCOIS, C., FLOCH, J. & LEROY, J-P. (1981) Leydig cell tumour with gynaecomastia: hormonal effects of an oestrogen-producing tumour. Journal of Clinical Endocrinology and Metabolism, 53, 1291.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1136\/bmj.285.6356.1683","article-title":"Screening for carcinoma in situ of the contralateral testis in patients with germinal testicular cancer","volume":"285","author":"BERTHELSEN, J.G.; SKAKKEBAAK, N.S.; MAASE, H.V.O.N.D.E.R.; S0RENSEN, B.L.; MOGENSEN, P.","year":"1982","unstructured":"BERTHELSEN, J.G., SKAKKEBAAK, N.S., MAASE, H. VON DER, S0RENSEN, B.L. & MOGENSEN, P. (1982) Screening for carcinoma in situ of the contralateral testis in patients with germinal testicular cancer. British Medical Journal, 285, 1683.","journal-title":"British Medical Journal"},{"key":"ref_3","first-page":"42","article-title":"The pathology of testicular tumours","volume":"36","author":"COLLINs, D.A.; PUGH, R.C.B.","year":"1964","unstructured":"COLLINs, D.A. & PUGH, R.C.B. (1964) The pathology of testicular tumours. British Journal of Urology, 36, (Suppl.) 42.","journal-title":"British Journal of Urology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1699-0463.1957.tb01019.x","article-title":"Interstitial tumours of the testis. Two cases and survey","volume":"41","author":"DALGAARD, J.B.; HASSELBERG, F.","year":"1957","unstructured":"DALGAARD, J.B. & HASSELBERG, F. (1957) Interstitial tumours of the testis. Two cases and survey. Acta Pathologica et Microbiologia Scandinavica, 41, 219.","journal-title":"Acta Pathologica et Microbiologia Scandinavica"},{"issue":"1","key":"ref_5","article-title":"Tumours of the Male Sex Organs. In: Atlas of Tumour Pathology","volume":"11","author":"DIXON, F.J.; MOORE, R.A.","year":"1952","unstructured":"DIXON, F.J. & MOORE, R.A. (1952) Tumours of the Male Sex Organs. In: Atlas of Tumour Pathology. Section 11 1. Fasc. 316 and 32. Washington D.C. Armed Forces, Institute of Pathology.","journal-title":"Section"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/1097-0142(197504)35:4<1184::AID-CNCR2820350425>3.0.CO;2-Z","article-title":"Feminising interstitial cell tumour of the testis: personal observations and a review of the literature","volume":"35","author":"GABRILOVE, J.L.; NICOLIS, G.L.; MITTY, H.A.; SOHVAL, A.R.","year":"1975","unstructured":"GABRILOVE, J.L., NICOLIS, G.L., MITTY, H.A. & SOHVAL, A.R. (1975) Feminising interstitial cell tumour of the testis: personal observations and a review of the literature. Cancer, 35, 1184.","journal-title":"Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/ajcp\/67.6.562","article-title":"Leydig cell tumour of the testis with gynaecomastia and elevated oestrogen levels","volume":"67","author":"SHIMPIUS, W.S.; SCHULTZ, A.L.; HASTINGS, J.R.; ANDERSON, W.R.","year":"1977","unstructured":"SHIMPIUS, W.S., SCHULTZ, A.L., HASTINGS, J.R. & ANDERSON, W.R. (1977) Leydig cell tumour of the testis with gynaecomastia and elevated oestrogen levels. American Journal of Clinical Pathology, 67, 562.","journal-title":"American Journal of Clinical Pathology"},{"key":"ref_8","article-title":"Carcinoma in situ of testis and orchiectomy","volume":"204","author":"SKAKKEBAAK, N.E.; BERTHELSEN, J.G.","year":"1978","unstructured":"SKAKKEBAAK, N.E. & BERTHELSEN, J.G. (1978) Carcinoma in situ of testis and orchiectomy. Lancet, ii, 204.","journal-title":"Lancet"},{"key":"ref_9","article-title":"Accepted","year":"1983","unstructured":"(Accepted 16 February 1983)"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/60\/699\/66\/50201344\/postgradmedj-60-66.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/60\/699\/66\/50201344\/postgradmedj-60-66.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T09:12:21Z","timestamp":1683277941000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/60\/699\/66\/7048124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1,1]]},"references-count":9,"journal-issue":{"issue":"699","published-online":{"date-parts":[[1984,1,1]]},"published-print":{"date-parts":[[1984,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.60.699.66","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1984,1]]},"published":{"date-parts":[[1984,1,1]]}}}