{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T13:17:12Z","timestamp":1697980632509},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"703","license":[{"start":{"date-parts":[[1984,5,1]],"date-time":"1984-05-01T00:00:00Z","timestamp":452217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Four patients are described who had a significant elevation of serum thyroxine-binding globulin (TBG). Review of these patients indicated that inappropriate therapy for thyrotoxicosis had been given in three cases. A study of our laboratory records revealed that significant TBG elevation was a relatively common phenomenon which occurred in approximately 0.45% of our hospital population. Patients with this abnormality have serum thyroxine levels which are comparable to those with clinical thyrotoxicosis. Tri-iodothyronine is frequently elevated though less so than in patients with clinical thyrotoxicosis. Measurement of TBG is indicated in all cases of hyperthyroxinaemia in which the clinical features of thyrotoxicosis are doubtful. The TRH test was found to be most useful in evaluating the thyroid status of these patients.<\/jats:p>","DOI":"10.1136\/pgmj.60.703.324","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"324-327","source":"Crossref","is-referenced-by-count":3,"title":["High serum thyroxine-binding globulin\u2014an important cause of hyperthyroxinaemia"],"prefix":"10.1093","volume":"60","author":[{"given":"Bernard C.","family":"Leahy","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Manchester Royal Infirmary , Manchester MJ3 9WL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Manchester Royal Infirmary , Manchester MJ3 9WL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Laing","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Manchester Royal Infirmary , Manchester MJ3 9WL"},{"name":"Department of Clinical Biochemistry, Manchester Royal Infirmary , Manchester MJ3 9WL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Walton","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Manchester Royal Infirmary , Manchester MJ3 9WL"},{"name":"Department of Clinical Biochemistry, Manchester Royal Infirmary , Manchester MJ3 9WL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1984,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1172\/JCI103946","article-title":"Familial increases in the thyroxine-binding sites in serum alpha globulin","volume":"38","author":"BEIERWALTES, S.H.; ROBBINS, J.","year":"1959","unstructured":"BEIERWALTES, S.H. & ROBBINS, J. (1959) Familial increases in the thyroxine-binding sites in serum alpha globulin. Journal of Clinical Investigation, 38, 1683.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_2","first-page":"507","article-title":"Preparation of a monospecific antiserum to thyroxine-binding globulin for its quantitation by rocket immunoelectrophoresis","volume":"71","author":"BRADWELL, A.R.; BURNETT, D.; RAMSDEN, D.B.; BURR, W.A.; PRINCE, H.P.; HOTTENBURG, R.","year":"1976","unstructured":"BRADWELL, A.R., BURNETT, D., RAMSDEN, D.B., BURR, W.A., PRINCE, H.P. & HOTTENBURG, R. (1976) Preparation of a monospecific antiserum to thyroxine-binding globulin for its quantitation by rocket immunoelectrophoresis. Clinica Chimica Acta, 71, 507.","journal-title":"Clinica Chimica Acta"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1365-2265.1979.tb03082.x","article-title":"The ratio of thyroxine to thyroxine-binding globulin in the assessment of thyroid function","volume":"11","author":"BURR, W.A.; EVANS, S.E.; LEE, J.; PRINCE, H.P.; RAMSDEN, D.B.","year":"1979","unstructured":"BURR, W.A., EVANS, S.E., LEE, J., PRINCE, H.P. & RAMSDEN, D.B. (1979) The ratio of thyroxine to thyroxine-binding globulin in the assessment of thyroid function. Clinical Endocrinology, 11, 333.","journal-title":"Clinical Endocrinology"},{"key":"ref_4","first-page":"55","article-title":"The effect of drugs on the distribution and metabolism of thyroid hormones","volume":"33","author":"CAVALIERI, R.; PITT-RIVERS, R.","year":"1981","unstructured":"CAVALIERI, R. & PITT-RIVERS, R. (1981) The effect of drugs on the distribution and metabolism of thyroid hormones. 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Lancet, ii, 849.","journal-title":"Lancet"},{"key":"ref_10","first-page":"6","article-title":"X-chromosome linked inheritance of elevated thyroxine-binding globulin","volume":"30","author":"JONES, J.E.; SEAL, V.S.","year":"1967","unstructured":"JONES, J.E. & SEAL, V.S. (1967) X-chromosome linked inheritance of elevated thyroxine-binding globulin. Journal of Clinical Endocrinology, 30, 6.","journal-title":"Journal of Clinical Endocrinology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1056\/NEJM198204223061605","article-title":"Familial euthyroid hyperthyroxinemia from increased thyroxine binding to thyroxine-binding prealbumin","volume":"306","author":"MOSES, A.C.; LAWLOR, J.J.; HADDOW, J.; JACKSON, I.M.D.","year":"1982","unstructured":"MOSES, A.C., LAWLOR, J.J., HADDOW, J. & JACKSON, I.M.D. (1982) Familial euthyroid hyperthyroxinemia from increased thyroxine binding to thyroxine-binding prealbumin. 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