{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T19:28:52Z","timestamp":1781638132660,"version":"3.54.5"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"703","license":[{"start":{"date-parts":[[1984,5,1]],"date-time":"1984-05-01T00:00:00Z","timestamp":452217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A patient with inappropriate thyrotrophin (TSH) secretion is described. She initially presented with classical hyperthyroidism during pregnancy, responded to propylthiouracil and, subsequently, had a normal delivery. Hyperthyroidism persisted and 7.5 months later a subtotal thyroidectomy was performed. After a further 16 months, mild symptoms of hyperthyroidism recurred. She again responded to propylthiouracil, but developed galactorrhoea. At that stage, it was noted that she had persistently elevated circulating TSH in the presence of elevated T4 and T3 levels. Her symptomatology was mild, although objective indices of thyroid activity, including pulse rate, BMR, sex hormone binding globulin and cholesterol, were indicative of hyperthyroidism. CT scan and tomography of the sella were normal.<\/jats:p>\n               <jats:p>She had a markedly exaggerated TSH response to thyrotrophin releasing hormone (TRH). Basal TSH and responsiveness to TRH was suppressed by high dose dexamethasone. The TSH response to TRH was partially suppressed by exogenous T3, but there was no effect on basal TSH levels. TSH also decreased slightly with L-dopa and bromocriptine. Circulating TSH rose markedly during methimazole administration. TSH \u03b1 and \u03b2 subunits were elevated and appropriate for the high TSH. In addition, both subunits increased following TRH. The patient had basal hyperprolactinaemia with an impaired prolactin (PRL) response to TRH and metoclopramide. PRL suppressed with L-dopa and bromocriptine. The remaining anterior pituitary function was intact. Most of the laboratory findings argue against the presence of a TSH producing pituitary tumour and the most likely cause for inappropriate TSH secretion in this patient is selective resistance of the thyrotroph to thyroid hormones. A mild element of peripheral resistance might also be present. The hyperprolactinaemia could be related to lactotroph resistance to thyroid hormone.<\/jats:p>\n               <jats:p>The complexities of treatment in this patient are stressed. Therapy was initially attempted with low dose dexamethasone, but this had no effect. T3 treatment produced an exacerbation of her symptomatology and did not influence basal TSH, thyroid hormones, or 131I uptake. Bromocriptine administration for 11 months partially suppressed basal TSH without influencing T3 and there was an increase in T4. Methimazole did decrease her T4 and T3, but TSH and PRL rose to even greater levels. Her hyperthyroidism was eventually controlled with an ablative dose of 131I. Thyroid hormone will be given in an attempt to suppress her TSH.<\/jats:p>","DOI":"10.1136\/pgmj.60.703.328","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"328-335","source":"Crossref","is-referenced-by-count":8,"title":["Hyperthyroidism due to inappropriate TSH secretion with associated hyperprolactinaemia\u2014a case report and review of the literature"],"prefix":"10.1093","volume":"60","author":[{"given":"Irving M.","family":"Spitz","sequence":"first","affiliation":[{"name":"Population Council , New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim","family":"Sheinfeld","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Lady Davis Carmel Hospital , Haifa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Glasser","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Lady Davis Carmel Hospital , Haifa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry J.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shaare Zedek Medical Center and Hadassah University Medical School , Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1984,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2265.1976.tb02825.x","article-title":"Case of hyperthyroidism due to a chromophobe adenoma","volume":"5","author":"BAYLIS, P.H.","year":"1976","unstructured":"BAYLIS, P.H. (1976) Case of hyperthyroidism due to a chromophobe adenoma. Clinical Endocrinology, 5, 145.","journal-title":"Clinical Endocrinology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2265.1980.tb03127.x","article-title":"Hyperthyroidism due to a pituitary TSH secreting tumour with amenorrheagalactorrhea","volume":"12","author":"BENOIT, R.; PEARSON-MURPHY, B.E.; ROBERT, F.; MARCOVITZ, S.; HARDY, J.; TsoUKAs, G.; GARDINER, R.J.","year":"1980","unstructured":"BENOIT, R., PEARSON-MURPHY, B.E., ROBERT, F., MARCOVITZ, S., HARDY, J., TsoUKAs, G. & GARDINER, R.J. (1980) Hyperthyroidism due to a pituitary TSH secreting tumour with amenorrheagalactorrhea. Clinical Endocrinology, 12, 11.","journal-title":"Clinical Endocrinology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1172\/JCI107240","article-title":"Partial target organ resistance to thyroid hormone","volume":"52","author":"BODE, H.H.; DANON, M.; WEINTRAUB, B.D.; MALOOF, F.; CRAWFORD, J.D.","year":"1973","unstructured":"BODE, H.H., DANON, M., WEINTRAUB, B.D., MALOOF, F. & CRAWFORD, J.D. (1973) Partial target organ resistance to thyroid hormone. Journal of Clinical Investigation, 52, 776.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/0002-9343(81)90169-8","article-title":"Familial thyroid hormone resistance","volume":"71","author":"BROOKS, M.H.; BARBATO, A.L.; COLLINS, S.; GARBINCIUS, J.; NEIDBALLA, R.G.; HOFFMAN, D.","year":"1981","unstructured":"BROOKS, M.H., BARBATO, A.L., COLLINS, S., GARBINCIUS, J., NEIDBALLA, R.G. & HOFFMAN, D. (1981) Familial thyroid hormone resistance. American Journal of Medicine, 71, 414.","journal-title":"American Journal of Medicine"},{"key":"ref_5","first-page":"499","article-title":"Pituitary thyroidstimulating hormone and other thyroid stimulating substances","author":"CONDLIFFE, P.G.; WEINTRAUB, B.D.","year":"1979","unstructured":"CONDLIFFE, P.G. & WEINTRAUB, B.D. (1979) Pituitary thyroidstimulating hormone and other thyroid stimulating substances. In: Hormones in Blood. (Eds. C. H. Gray and V. H. T. James), p. 499. Academic Press, Inc., London."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/0026-0495(82)90242-6","article-title":"Familial thyroid hormone resistance","volume":"31","author":"COOPER, D.S.; LADENSON, P.W.; NISULA, B.C.; DUNN, J.F.; CHAPMAN, E.M.; RIDGWAY, E.C.","year":"1982","unstructured":"COOPER, D.S., LADENSON, P.W., NISULA, B.C., DUNN, J.F., CHAPMAN, E.M. & RIDGWAY, E.C. (1982) Familial thyroid hormone resistance. Metabolism, 31, 504.","journal-title":"Metabolism"},{"key":"ref_7","first-page":"255","article-title":"Pituitary adenoma producing thyrotropin and prolatin. An immunocytochemical and electron microscopic study","volume":"376","author":"DUELLO, T.M.; HALMI, N.S.","year":"1977","unstructured":"DUELLO, T.M. & HALMI, N.S. (1977) Pituitary adenoma producing thyrotropin and prolatin. An immunocytochemical and electron microscopic study. Virchows Archiv fur pathologische Anatomie und Physiologie undfur klinische Medizin, 376, 255.","journal-title":"Physiologie undfur klinische; Medizin"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1210\/jcem-43-3-575","article-title":"Familial partial target organ resistance to thyroid hormones","volume":"43","author":"ELEWAUT, A.; MUSSCHE, M.; VERMEULEN, A.","year":"1976","unstructured":"ELEWAUT, A., MUSSCHE, M. & VERMEULEN, A. (1976) Familial partial target organ resistance to thyroid hormones. Journal of Clinical Endocrinology and Metabolism, 43, 575.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1056\/NEJM197208172870704","article-title":"Hyperthyroidism and excessive thyrotropin secretion","volume":"287","author":"EMERSON, C.H.; UTIGER, R.D.","year":"1972","unstructured":"EMERSON, C.H. & UTIGER, R.D. (1972) Hyperthyroidism and excessive thyrotropin secretion. New England Journal ofMedicine, 287, 328.","journal-title":"New England Journal ofMedicine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1210\/jcem-15-1-81","article-title":"The mechanism of induction and the characteristics of pituitary tumors induced by thyroidectomy","volume":"15","author":"FURTH, J.; DENT, N.N.; BURNETT, W.T.; GADSDEN, E.L.","year":"1955","unstructured":"FURTH, J., DENT, N.N., BURNETT, W.T. & GADSDEN, E.L. (1955) The mechanism of induction and the characteristics of pituitary tumors induced by thyroidectomy. Journal of Clinical Endocrinology and Metabolism, 15, 81.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_11","first-page":"217","article-title":"Thyrotropic tumour syndrome","volume":"96","author":"FURTH, J.; MoY, P.; HERSHMAN, J.M.; VEDA, G.","year":"1973","unstructured":"FURTH, J., MoY, P., HERSHMAN, J.M. & VEDA, G. (1973) Thyrotropic tumour syndrome. Archives of Pathology, 96, 217.","journal-title":"Archives of Pathology"},{"key":"ref_12","first-page":"339","article-title":"Inappropriate thyroid-stimulating hormone secretion: description and classification. In: Inappropriate Secretion of Thyroid Stimulating Hormone, Annals of Internal Medicine","author":"GERSHENGORN, M.C.","year":"1981","unstructured":"GERSHENGORN, M.C. (1981) Inappropriate thyroid-stimulating hormone secretion: description and classification. In: Inappropriate Secretion of Thyroid Stimulating Hormone, Annals of Internal Medicine. (Ed. B. D. Weintraub), 95, 339."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1172\/JCI108133","article-title":"Thyrotropininduced hyperthyroidism caused by selective pituitary resistance to thyroid hormone: a new syndrome of 'inappropriate secretion of TSH'","volume":"56","author":"GERSHENGORN, M.C.; WEINTRAUB, B.D.","year":"1975","unstructured":"GERSHENGORN, M.C. & WEINTRAUB, B.D. (1975) Thyrotropininduced hyperthyroidism caused by selective pituitary resistance to thyroid hormone: a new syndrome of 'inappropriate secretion of TSH'. Journal of Clinical Investigation, 56, 633.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1210\/jcem-43-1-137","article-title":"Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor","volume":"43","author":"HORN, K.; ERHARDT, F.; FAHLBUSCH, R.; PICKARDT, C.R.; WER-DER, K.V.; SCRIBA, P.C.","year":"1976","unstructured":"HORN, K., ERHARDT, F., FAHLBUSCH, R., PICKARDT, C.R., WER-DER, K.V. & SCRIBA, P.C. (1976) Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. Journal of Clinical Endocrinology and Metabolism, 43, 137.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_15","first-page":"95","article-title":"The thyroid gland. In: Textbook of Endocrinology","author":"INGBAR, S.H.; WOEBER, K.A.","year":"1974","unstructured":"INGBAR, S.H. & WOEBER, K.A. (1974) The thyroid gland. In: Textbook of Endocrinology, (Ed. R. H. Williams), ch. 4, p. 95. W."},{"key":"ref_16","first-page":"1115","article-title":"Partial peripheral resistance to thyroid hormone","volume":"70","author":"KAPLAN, M.M.; SWARTZ, S.L.; LARSON, P.","year":"1981","unstructured":"KAPLAN, M.M., SWARTZ, S.L. & LARSON, P. REED (1981) Partial peripheral resistance to thyroid hormone. American Journal of Medicine, 70, 1115.","journal-title":"REED"},{"key":"ref_17","first-page":"339","article-title":"Inappropriate thyroid-stimulating hormone secretion: description and classification. In: Inappropriate Secretion of Thyroid-Stimulating Hormone, Annals of Internal Medicine","author":"KOURIDES, M.D.","year":"1981","unstructured":"KOURIDES, M.D. (1981) Inappropriate thyroid-stimulating hormone secretion: description and classification. In: Inappropriate Secretion of Thyroid-Stimulating Hormone, Annals of Internal Medicine (Ed. B. D. Weintraub), 95, 339."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1210\/jcem-45-3-534","article-title":"Thyrotropin-induced hyperthyroidism: use of alpha and beta subunit levels to identify patients with pituitary tumors","volume":"45","author":"KOURIDES, I.A.; RIDGWAY, E.C.; WEINTRAUB, B.D.; BIGOS, S.T.; GERSHENGORN, M.C.; MALOOF, F.","year":"1977","unstructured":"KOURIDES, I.A., RIDGWAY, E.C., WEINTRAUB, B.D., BIGOS, S.T., GERSHENGORN, M.C. & MALOOF, F. (1977) Thyrotropin-induced hyperthyroidism: use of alpha and beta subunit levels to identify patients with pituitary tumors. Journal of Clinical Endocrinology and Metabolism, 45, 534.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1210\/jcem-40-5-872","article-title":"Pituitary secretion of free alpha and beta subunit of human thyrotropin in patients with thyroid disorders","volume":"40","author":"KOURIDES, I.A.; WEINTRAUB, B.D.; RIDGWAY, E.C.; MALOOF, F.","year":"1975","unstructured":"KOURIDES, I.A., WEINTRAUB, B.D., RIDGWAY, E.C. & MALOOF, F. (1975) Pituitary secretion of free alpha and beta subunit of human thyrotropin in patients with thyroid disorders. Journal of Clinical Endocrinology and Metabolism, 40, 872.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_20","article-title":"Congenital euthyroid goiter and partial peripheral resistance to thyroid hormones","volume":"854","author":"LAMBERG, B.A.","year":"1973","unstructured":"LAMBERG, B.A. (1973) Congenital euthyroid goiter and partial peripheral resistance to thyroid hormones. Lancet, i, 854.","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1530\/acta.0.0970103","article-title":"The TSH response to TRH is exaggerated in primary testicular failure and normal in the male castrate","volume":"97","author":"LERoiTH, D.; LIEL, Y.; SACK, J.; LIVSHIN, Y.; LAUFER, N.; SCHENKER, J.; SPITZ, I.M.","year":"1981","unstructured":"LERoiTH, D., LIEL, Y., SACK, J., LIVSHIN, Y., LAUFER, N., SCHENKER, J. & SPITZ, I.M. (1981) The TSH response to TRH is exaggerated in primary testicular failure and normal in the male castrate. Acta Endocrinologica, 97, 103.","journal-title":"Acta Endocrinologica"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/0026-0495(82)90243-8","article-title":"Familial insensitivity of the pituitary and periphery to thyroid hormone: a case report in two generation and a review of the literature","volume":"31","author":"LINDE, R.; ALEXANDER, N.; ISLAND, D.P.; RABIN, D.","year":"1982","unstructured":"LINDE, R., ALEXANDER, N., ISLAND, D.P. & RABIN, D. (1982) Familial insensitivity of the pituitary and periphery to thyroid hormone: a case report in two generation and a review of the literature. Metabolism, 31, 510.","journal-title":"Metabolism"},{"key":"ref_23","first-page":"334","article-title":"A filter assay for the sex steroid binding protein (SBP) of human serum","volume":"44","author":"MICKELSON, K.E.; PETRA, P.H.","year":"1974","unstructured":"MICKELSON, K.E. & PETRA, P.H. (1974) A filter assay for the sex steroid binding protein (SBP) of human serum. Febs Letters, 44, 334.","journal-title":"Febs Letters"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1210\/jcem-50-6-1135","article-title":"Hyperthyroidism due to excess thyrotropin secretion: follow-up studies","volume":"50","author":"MIHAILOVIC, V.; FELLER, M.S.; KOURIDES, I.A.; UTIGER, R.D.","year":"1980","unstructured":"MIHAILOVIC, V., FELLER, M.S., KOURIDES, I.A. & UTIGER, R.D. (1980) Hyperthyroidism due to excess thyrotropin secretion: follow-up studies. Journal of Clinical Endocrinology and Metabolism, 50, 1135.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1210\/jcem-45-5-1053","article-title":"Juvenile hyperthyroidism with elevated thyrotropin (TSH) and normal 24 hour FSH, LH, GH, and prolactin secretory patterns","volume":"45","author":"NOVOGRODER, M.; UTIGER, R.; BOYAR, R.; LEVINE, L.S.","year":"1977","unstructured":"NOVOGRODER, M., UTIGER, R., BOYAR, R. & LEVINE, L.S. (1977) Juvenile hyperthyroidism with elevated thyrotropin (TSH) and normal 24 hour FSH, LH, GH, and prolactin secretory patterns. Journal of Clinical Endocrinology and Metabolism, 45, 1053.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1210\/jcem-43-2-338","article-title":"The effect of glucocorticoid administration on human pituitary secretion of thyrotropin and prolactin","volume":"43","author":"RE, R.N.; KOURIDES, I.A.; RIDGWAY, E.C.; WEINTRAUB, B.D.; MALOOF, F.","year":"1976","unstructured":"RE, R.N., KOURIDES, I.A., RIDGWAY, E.C., WEINTRAUB, B.D. & MALOOF, F. (1976) The effect of glucocorticoid administration on human pituitary secretion of thyrotropin and prolactin. Journal of Clinical Endocrinology and Metabolism, 43, 338.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1210\/jcem-27-2-279","article-title":"Familial syndrome combining deaf-mutism, stippled epiphyses, goiter and abnormally high PBI: possible target organ refractoriness to thyroid hormone","volume":"27","author":"REFETOFF, S.; DEWIND, L.T.; DEGROOT, L.J.","year":"1967","unstructured":"REFETOFF, S., DEWIND, L.T. & DEGROOT, L.J. (1967) Familial syndrome combining deaf-mutism, stippled epiphyses, goiter and abnormally high PBI: possible target organ refractoriness to thyroid hormone. Journal of Clinical Endocrinology and Metabolism, 27, 279.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1210\/jcem-43-4-924","article-title":"Hyperthyroidism with elevated plasma TSH levels and pituitary tumour: study with somatostatin","volume":"43","author":"RESCHINI, E.; GIUSTINA, G.; CANTALAMESSA, L.; PERACCHI, M.","year":"1976","unstructured":"RESCHINI, E., GIUSTINA, G., CANTALAMESSA, L. & PERACCHI, M. (1976) Hyperthyroidism with elevated plasma TSH levels and pituitary tumour: study with somatostatin. Journal of Clinical Endocrinology and Metabolism, 43, 924.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_29","author":"ROSLER, A.; LITVIN, Y.; HAGE, C.; GROSS, J.; CERASI, E.","year":"1982","unstructured":"ROSLER, A., LITVIN, Y., HAGE, C., GROSS, J. & CERASI, E. (1982)"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1210\/jcem-54-1-76","article-title":"Familial hyperthyroidism due to inappropriate TSH secretion successfully treated with tri-iodothyronine","volume":"54","unstructured":"Familial hyperthyroidism due to inappropriate TSH secretion successfully treated with tri-iodothyronine. Journal of Clinical Endocrinology and Metabolism, 54, 76.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1210\/jcem-45-5-903","article-title":"Endocrine and morphologic studies of pituitary adenomas secondary to primary hypothyroidism","volume":"45","author":"SAMAAN, N.A.; OSBORNE, B.M.; MACKAY, B.; LEAVENS, M.E.; DUELLO, T.M.; HALMI, N.S.","year":"1977","unstructured":"SAMAAN, N.A., OSBORNE, B.M., MACKAY, B., LEAVENS, M.E., DUELLO, T.M. & HALMI, N.S. (1977) Endocrine and morphologic studies of pituitary adenomas secondary to primary hypothyroidism. Journal of Clinical Endocrinology and Metabolism, 45, 903.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1507\/endocrj1954.26.623","article-title":"A case of the syndrome of inappropriate secretion of TSH","volume":"26","author":"SATO, T.; SAIDA, K.; SUZUKI, Y.; TAKATA, I.; ISHIGURO, K.","year":"1979","unstructured":"SATO, T., SAIDA, K., SUZUKI, Y., TAKATA, I. & ISHIGURO, K. (1979) A case of the syndrome of inappropriate secretion of TSH. Endocrinologia Japonica, 26, 623.","journal-title":"Endocrinologia Japonica"},{"key":"ref_33","first-page":"333","article-title":"The neuroregulation of human thyrotropin secretion","volume-title":"Frontiers in Neuroendocrinology","author":"SCANLON, M.F.; LEWIS, M.; WEIGHTMAN, D.R.; CHAN, V.; HALL, R.","year":"1980","unstructured":"SCANLON, M.F., LEWIS, M., WEIGHTMAN, D.R., CHAN, V. & HALL, R. (1980) The neuroregulation of human thyrotropin secretion. In: Frontiers in Neuroendocrinology (Eds. L. Martini and W. F. Ganong), ch. 4, p. 333, Raven Press, New York."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1172\/JCI107166","article-title":"Modulation of pituitary responsiveness to thyrotropin-releasing hormone by tri-iodothyronine","volume":"52","author":"SHENKMAN, L.; MITSUMA, T.; HOLLANDER, C.","year":"1973","unstructured":"SHENKMAN, L., MITSUMA, T. & HOLLANDER, C. (1973) Modulation of pituitary responsiveness to thyrotropin-releasing hormone by tri-iodothyronine. Journal of Clinical Investigation, 52, 205.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1210\/jcem-48-4-700","article-title":"Inappropriate secretion of thyrotropin: discordance between the suppressive effects of corticosteroid and thyroid hormone","volume":"48","author":"SMALLRIDGE, R.C.; WARTOFSKY, L.; DIMOND, R.C.","year":"1979","unstructured":"SMALLRIDGE, R.C., WARTOFSKY, L. & DIMOND, R.C. (1979) Inappropriate secretion of thyrotropin: discordance between the suppressive effects of corticosteroid and thyroid hormone. Journal of Clinical Endocrinology and Metabolism, 48, 700.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1172\/JCI107421","article-title":"Thyroid hormone inhibition of the prolactin response to thyrotropin-releasing hormone","volume":"52","author":"SNYDER, P.J.; JACOBS, L.S.; UTIGER, R.D.; DAUGHADAY, W.H.","year":"1973","unstructured":"SNYDER, P.J., JACOBS, L.S., UTIGER, R.D. & DAUGHADAY, W.H. (1973) Thyroid hormone inhibition of the prolactin response to thyrotropin-releasing hormone. Journal of Clinical Investigation, 52, 2324.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_37","first-page":"149","article-title":"Agnogenic and stimulus initiated growth hormone release in man. A reappraisal and a multiple pool model of hormonal release","volume":"131","author":"SPITZ, I.M.; GONEN, B.; RABINOWITZ, D.","year":"1979","unstructured":"SPITZ, I.M., GONEN, B. & RABINOWITZ, D. (1979) Agnogenic and stimulus initiated growth hormone release in man. A reappraisal and a multiple pool model of hormonal release. Johns Hopkins Medical Journal, 131, 149.","journal-title":"Johns Hopkins Medical Journal"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0015-0282(16)45198-8","article-title":"Exaggerated prolactin response to thyrotropin-releasing hormone and metoclopramide in primary testicular failure","volume":"34","author":"SPITZ, I.M.; LEROITH, D.; LIVSHIN, Y.; ZYLBER-HARAN, E.; TRESTIAN, S.; LAUFER, N.; PALTI, R.M.; SCHENKER, J.","year":"1980","unstructured":"SPITZ, I.M., LEROITH, D., LIVSHIN, Y., ZYLBER-HARAN, E., TRESTIAN, S., LAUFER, N., PALTI, R.M. & SCHENKER, J. (1980) Exaggerated prolactin response to thyrotropin-releasing hormone and metoclopramide in primary testicular failure. Fertility and Sterility, 34, 573.","journal-title":"Fertility and Sterility"},{"key":"ref_39","article-title":"Sexhormonbindendes globulin (SHBG) ein neuer metabol ischer in vitro test der schilderdrusenfunktion","volume":"108","author":"STAUB, J.J.; CONTI, A.; HUBER, T.","year":"1978","unstructured":"STAUB, J.J., CONTI, A. & HUBER, T. (1978) Sexhormonbindendes globulin (SHBG) ein neuer metabol ischer in vitro test der schilderdrusenfunktion. Schweizerische Medizinische Wochenschrift, 108, 1909.","journal-title":"Schweizerische Medizinische Wochenschrift"},{"issue":"431 1","key":"ref_40","article-title":"Pituitary and peripheral resistance to thyroid hormone","volume":"10","author":"TAMAGNA, E.I.; CARLSON, H.E.; HERSHMAN, J.M.; REED, A.W.","year":"1979","unstructured":"TAMAGNA, E.I., CARLSON, H.E., HERSHMAN, J.M. & REED, A.W. (1979) Pituitary and peripheral resistance to thyroid hormone. Clinical Endocrinology, 10, 431 1.","journal-title":"Clinical Endocrinology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0002-9343(78)90202-4","article-title":"Pituitary hyperthyroidism: case report and review of the literature","volume":"64","author":"TOLls, G.; BIRD, C.; BERTRAND, G.; MCKENZIE, J.M.; EZRIN, C.","year":"1978","unstructured":"TOLls, G., BIRD, C., BERTRAND, G., MCKENZIE, J.M. & EZRIN, C. (1978) Pituitary hyperthyroidism: case report and review of the literature. American Journal of Medicine, 64, 177.","journal-title":"American Journal of Medicine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"195","DOI":"10.7326\/0003-4819-85-2-195","article-title":"Pituitary enlargement, pituitary failure and primary hypothyroidism","volume":"85","author":"VAGENAKIS, A.G.; DOLE, K.; BRAVERMAN, L.E.","year":"1976","unstructured":"VAGENAKIS, A.G., DOLE, K. & BRAVERMAN, L.E. (1976) Pituitary enlargement, pituitary failure and primary hypothyroidism. Annals of Internal Medicine, 85, 195.","journal-title":"Annals of Internal Medicine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1210\/jcem-49-6-879","article-title":"Secondary hyperthyroidism due to thyrotropin hypersecretion: study of pituitary tumour morphology and thyrotropin chemistry and release","volume":"49","author":"WALDHAUSL, W.; BRATUSCH-MARRAIN, P.; NOWOTNY, P.; BuCHLER, M.; FORSSMANN, W.S.; LUJF, A.; SCHUSTER, W.","year":"1979","unstructured":"WALDHAUSL, W., BRATUSCH-MARRAIN, P., NOWOTNY, P., BuCHLER, M., FORSSMANN, W.S., LUJF, A. & SCHUSTER, W. (1979) Secondary hyperthyroidism due to thyrotropin hypersecretion: study of pituitary tumour morphology and thyrotropin chemistry and release. Journal of Clinical and Endocrinology Metabolism, 49, 879.","journal-title":"Journal of Clinical and Endocrinology Metabolism"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1055\/s-0028-1095788","article-title":"Human pituitary adenomas with hypersection of TSH and prolactin: evidence that receptor sites for dopamine may be absent on TSH producing while present on prolactin producing cells","volume":"11","author":"WERNER, S.","year":"1979","unstructured":"WERNER, S. (1979) Human pituitary adenomas with hypersection of TSH and prolactin: evidence that receptor sites for dopamine may be absent on TSH producing while present on prolactin producing cells. Hormone Metabolism Research, 11, 452.","journal-title":"Hormone Metabolism Research"},{"key":"ref_45","article-title":"Accepted","year":"1984","unstructured":"(Accepted 21 July 1984)"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/60\/703\/328\/50201701\/postgradmedj-60-328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/60\/703\/328\/50201701\/postgradmedj-60-328.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T08:42:41Z","timestamp":1683276161000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/60\/703\/328\/7048272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5,1]]},"references-count":45,"journal-issue":{"issue":"703","published-online":{"date-parts":[[1984,5,1]]},"published-print":{"date-parts":[[1984,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.60.703.328","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1984,5]]},"published":{"date-parts":[[1984,5,1]]}}}