{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T09:00:54Z","timestamp":1698051654394},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"704","license":[{"start":{"date-parts":[[1984,6,1]],"date-time":"1984-06-01T00:00:00Z","timestamp":454896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 78-year-old woman developed marked insulin lipoatrophy due to conventional bovine insulin injected into the upper limbs. Changing to a combination of highly purified porcine\/bovine insulins injected into the lower limbs resulted in the opposite effect, namely insulin-induced lipohypertrophy. Use was then made of this effect by injecting the highly purified insulins into the atrophied upper limb injection sites with resultant improvement in these wasted areas over the next 10 months.<\/jats:p>","DOI":"10.1136\/pgmj.60.704.439","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"439-441","source":"Crossref","is-referenced-by-count":3,"title":["Paradoxical lipodystrophic changes due to conventional bovine and highly purified porcine\/bovine insulins"],"prefix":"10.1093","volume":"60","author":[{"given":"I. W.","family":"Campbell","sequence":"first","affiliation":[{"name":"Medical Unit, Victoria Hospital , Kirkcaldy, Fife, KY2 5AH, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Medical Unit, Victoria Hospital , Kirkcaldy, Fife, KY2 5AH, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Anani","sequence":"additional","affiliation":[{"name":"Medical Unit, Victoria Hospital , Kirkcaldy, Fife, KY2 5AH, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1984,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1136\/bmj.1.6073.1389","article-title":"Vaccination scar with soft-tissue atrophy restored by local insulin treatment","volume":"1","author":"AMROLIWALLA, F.K.","year":"1977","unstructured":"AMROLIWALLA, F.K. (1977) Vaccination scar with soft-tissue atrophy restored by local insulin treatment. British Medical Journal, 1, 1389.","journal-title":"British Medical Journal"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/bmj.282.6259.190","article-title":"Lipoatrophy and monocomponent porcine insulin","volume":"282","author":"JONES, G.R.; STATHAM, B.; OWENS, D.R.; JONES, M.K.; HAYES, T.M.","year":"1981","unstructured":"JONES, G.R., STATHAM, B., OWENS, D.R., JONES, M.K. & HAYES, T.M. (1981) Lipoatrophy and monocomponent porcine insulin. British Medical Journal, 282, 190.","journal-title":"British Medical Journal"},{"key":"ref_3","first-page":"653","article-title":"Disorders of the skin in diabetes","author":"KRALL, L.P.; ZORRILLA, E.","year":"1971","unstructured":"KRALL, L.P. & ZORRILLA, E. (1971) Disorders of the skin in diabetes. In: Joslin's Diabetes Mellitus (Eds. A. Marble, P. White, R.F. Bradley and K.P. Krail), I Ith ed., p. 653."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1136\/bmj.285.6354.1539","article-title":"Bilateral abdominal lipohypertrophy after continuous subcutaneous infusion of insulin","volume":"285","author":"MEIER, A.; WEERAKOON, J.; DANDONA, P.","year":"1982","unstructured":"MEIER, A., WEERAKOON, J. & DANDONA, P. (1982) Bilateral abdominal lipohypertrophy after continuous subcutaneous infusion of insulin. British Medical Journal, 285, 1539.","journal-title":"British Medical Journal"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1136\/bmj.280.6230.1500","article-title":"Insulininduced lipoatrophy: evidence for an immune pathogenesis","volume":"280","author":"REEVES, W.G.; ALLEN, B.R.; TATrERSALL, R.B.","year":"1980","unstructured":"REEVES, W.G., ALLEN, B.R. & TATrERSALL, R.B. (1980) Insulininduced lipoatrophy: evidence for an immune pathogenesis. British Medical Journal, 280, 1500.","journal-title":"British Medical Journal"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1210\/endo-46-1-55","article-title":"Action of insulin on deposition of glycogen and storage of fat in subcutaneous tissue","volume":"46","author":"RENOLD, A.E.; MARBLE, A.; FAWCETT, D.W.","year":"1950","unstructured":"RENOLD, A.E., MARBLE, A. & FAWCETT, D.W. (1950) Action of insulin on deposition of glycogen and storage of fat in subcutaneous tissue. Endocrinology, 46, 55.","journal-title":"Endocrinology"},{"issue":"21 1","key":"ref_7","article-title":"Treatment of insulin lipoatrophy with monocomponent insulin","volume":"10","author":"TEUSCHER, A.","year":"1974","unstructured":"TEUSCHER, A. (1974) Treatment of insulin lipoatrophy with monocomponent insulin. Diabetologia, 10, 21 1.","journal-title":"Diabetologia"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/bmj.1.6155.25","article-title":"Very pure porcine insulin in clinical practice","volume":"1","author":"WRIGHT, A.D.; WALSH, C.H.; FITZGERALD, M.C.; MALINS, J.M.","year":"1979","unstructured":"WRIGHT, A.D., WALSH, C.H., FITZGERALD, M.C. & MALINS, J.M. (1979) Very pure porcine insulin in clinical practice. British Medical Journal, 1, 25.","journal-title":"British Medical Journal"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1136\/bmj.283.6287.349","article-title":"Insulin injection sites in diabetes-a neglected area?","volume":"283","author":"YOUNG, R.J.; STEEL, J.M.; FRIER, B.M.; DUNCAN, L.J.P.","year":"1981","unstructured":"YOUNG, R.J., STEEL, J.M., FRIER, B.M. & DUNCAN, L.J.P. (1981) Insulin injection sites in diabetes-a neglected area? British Medical Journal, 283, 349.","journal-title":"British Medical Journal"},{"key":"ref_10","author":"Accepted 4 May 1983)","unstructured":"(Accepted 4 May 1983)"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/60\/704\/439\/50201810\/postgradmedj-60-439.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/60\/704\/439\/50201810\/postgradmedj-60-439.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T08:31:20Z","timestamp":1683275480000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/60\/704\/439\/7048101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,6,1]]},"references-count":10,"journal-issue":{"issue":"704","published-online":{"date-parts":[[1984,6,1]]},"published-print":{"date-parts":[[1984,6,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.60.704.439","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1984,6]]},"published":{"date-parts":[[1984,6,1]]}}}