{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T08:40:59Z","timestamp":1683276059509},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"706","license":[{"start":{"date-parts":[[1984,8,1]],"date-time":"1984-08-01T00:00:00Z","timestamp":460166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>An 18-year-old boy with delayed puberty was found to have a large prolactinoma. Hypophysectomy led to a fall in serum prolactin concentration, although it remained markedly elevated. The introduction of replacement therapy, including testosterone, resulted in painful swelling of the breasts and galactorrhoea. Bromocriptine therapy resulted in a cessation of galactorrhoea and normalization of serum prolactin concentrations. The absence of galactorrhoea in association with an astronomical concentration of prolactin, and its onset in association with diminished prolactin concentrations following hypophysectomy and the introduction of testosterone therapy, indicate that galactorrhoea requires the presence of high prolactin concentrations to act on mature breast tissue. This would account for the rarity of galactorrhoea in prepubertal children with prolactinomas.<\/jats:p>","DOI":"10.1136\/pgmj.60.706.540","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"540-541","source":"Crossref","is-referenced-by-count":2,"title":["Galactorrhoea following hypophysectomy in a boy with a prolactinoma"],"prefix":"10.1093","volume":"60","author":[{"given":"P.","family":"Dandona","sequence":"first","affiliation":[{"name":"Metabolic Unit, Department of Chemical Pathology and Department of Neurosurgery, Royal Free Hospital and School of Medicine , Pond Street, London NW3 2QG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mohiuddin","sequence":"additional","affiliation":[{"name":"Metabolic Unit, Department of Chemical Pathology and Department of Neurosurgery, Royal Free Hospital and School of Medicine , Pond Street, London NW3 2QG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. W.","family":"Lindsay","sequence":"additional","affiliation":[{"name":"Metabolic Unit, Department of Chemical Pathology and Department of Neurosurgery, Royal Free Hospital and School of Medicine , Pond Street, London NW3 2QG"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1984,8,1]]},"reference":[{"key":"ref_1","first-page":"1613","article-title":"Lactation and galactorrhoea","volume-title":"Grune and","author":"ARAGONA, C.; FRIESEN, H.G.","year":"1979","unstructured":"ARAGONA, C. & FRIESEN, H.G. (1979) Lactation and galactorrhoea. In: Endocrinology, Vol. III. (Ed. L.J. de Groot) p. 1613. Grune and Stratton, New York."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1210\/jcem-45-4-825","article-title":"Hyperprolactinaemia as a cause of delayed puberty: successful treatment with bromocriptine","volume":"45","author":"KOENIG, M.P.; ZUPPINGER, K.; LEICHTI, B.","year":"1977","unstructured":"KOENIG, M.P., ZUPPINGER, K. & LEICHTI, B. (1977) Hyperprolactinaemia as a cause of delayed puberty: successful treatment with bromocriptine. Journal of Clinical Endocrinology, 45, 825.","journal-title":"Journal of Clinical Endocrinology"},{"key":"ref_3","first-page":"1200","article-title":"Hypothyroidism presenting with hyperprolactinaemia","volume":"28","author":"SEMPLE, C.G.; BEASTALL, G.H.; TEASDALE, G.H.; THOMSON, J.A.","year":"1983","unstructured":"SEMPLE, C.G., BEASTALL, G.H., TEASDALE, G.H. & THOMSON, J.A. (1983) Hypothyroidism presenting with hyperprolactinaemia. British Medical Journal, 28, 1200.","journal-title":"British Medical Journal"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0022-3476(82)80131-5","article-title":"Hyperprolactinaemia associated with advanced puberty in a male","volume":"101","author":"SLONIM, A.E.; GLICK, A.D.; ISLAND, D.P.; KASSELBERG, A.G.","year":"1982","unstructured":"SLONIM, A.E., GLICK, A.D., ISLAND, D.P. & KASSELBERG, A.G. (1982) Hyperprolactinaemia associated with advanced puberty in a male. Journal of Pediatrics, 101, 236.","journal-title":"Journal of Pediatrics"},{"key":"ref_5","article-title":"Hyperprolactinaemia in males with and without pituitary macroadenomas","volume":"129","author":"SPARK, R.F.; WILLS, C.A.; O'REILLY, G.; RANSIL, B.J.; BERGLUND, R.","year":"1982","unstructured":"SPARK, R.F., WILLS, C.A., O'REILLY, G., RANSIL, B.J. & BERGLUND, R. (1982) Hyperprolactinaemia in males with and without pituitary macroadenomas. Lancet, i, 129.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0022-3476(77)81242-0","article-title":"Galactorrhoea in a 12-year old boy with chromophobe adenoma","volume":"90","author":"METER, V.A.N.; L., Q.; GAREIS, F.J.; HAYES, J.W.; WILSON, C.B.","year":"1977","unstructured":"VAN METER, Q.L., GAREIS, F.J., HAYES, J.W. & WILSON, C.B. (1977) Galactorrhoea in a 12-year old boy with chromophobe adenoma. Journal of Pediatrics, 90, 756.","journal-title":"Journal of Pediatrics"},{"key":"ref_7","author":"Accepted 29","year":"1983","unstructured":"(Accepted 29 June 1983)"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/60\/706\/540\/50201898\/postgradmedj-60-540.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/60\/706\/540\/50201898\/postgradmedj-60-540.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T08:11:55Z","timestamp":1683274315000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/60\/706\/540\/7048075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,8,1]]},"references-count":7,"journal-issue":{"issue":"706","published-online":{"date-parts":[[1984,8,1]]},"published-print":{"date-parts":[[1984,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.60.706.540","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1984,8]]},"published":{"date-parts":[[1984,8,1]]}}}