{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:28:15Z","timestamp":1759541295968},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"707","license":[{"start":{"date-parts":[[1984,9,1]],"date-time":"1984-09-01T00:00:00Z","timestamp":462844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 20-year-old patient presented with primary amenorrhoea and growth hormone deficiency caused by a basal encephalocoele. She was found to have developed diabetes insipidus in the 8 years following diagnosis. Gonadotrophin release in response to bolus injection of luteinizing hormone-releasing hormone (LHRH) was normal, as was thyrotrophin and adrenocorticotrophin (ACTH) secretion. Pulsatile administration of LHRH by the subcutaneous route resulted in normal ovulation and subsequent menstruation. The investigation and management of patients with basal encephalocoeles are discussed in the light of these findings.<\/jats:p>","DOI":"10.1136\/pgmj.60.707.597","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"597-604","source":"Crossref","is-referenced-by-count":6,"title":["Hypothalamic hypopituitarism in a patient with a basal encephalocoele\u2014treatment with luteinizing hormone-releasing hormone"],"prefix":"10.1093","volume":"60","author":[{"given":"D. V.","family":"Morris","sequence":"first","affiliation":[{"name":"Middlesex Hospital , Mortimer Street, London W1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. P.","family":"Mason","sequence":"additional","affiliation":[{"name":"Middlesex Hospital , Mortimer Street, London W1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Wilson-Holt","sequence":"additional","affiliation":[{"name":"Middlesex Hospital , Mortimer Street, London W1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Adams","sequence":"additional","affiliation":[{"name":"Middlesex Hospital , Mortimer Street, London W1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Keene","sequence":"additional","affiliation":[{"name":"Middlesex Hospital , Mortimer Street, London W1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tanner","sequence":"additional","affiliation":[{"name":"Middlesex Hospital , Mortimer Street, London W1"},{"name":"Institute of Child Health , Guildford Street, London W1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. S.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Middlesex Hospital , Mortimer Street, London W1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1984,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1172\/JCI107798","article-title":"Human puberty: Simultaneus segmented secretion of luteinising hormone and testosterone during sleep","volume":"54","author":"BOYAR, R.M.; ROSENFELD, R.S.; KAPEN, S.","year":"1974","unstructured":"BOYAR, R.M., ROSENFELD, R.S. & KAPEN, S. (1974) Human puberty: Simultaneus segmented secretion of luteinising hormone and testosterone during sleep. 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(1980) Experimental induction of puberty in the infantile female rhesus monkey. Science, 207, 1373.","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1210\/jcem-35-6-897","article-title":"Gonadotropin dynamics in patients with gonadal dysgenesis: a model for the study of gonadotropin regulation","volume":"35","author":"YEN, S.S.C.; TSAI, C.C.; VANDENBERG, G.; REBAR, R.","year":"1972","unstructured":"YEN, S.S.C., TSAI, C.C., VANDENBERG, G. & REBAR, R. (1972) Gonadotropin dynamics in patients with gonadal dysgenesis: a model for the study of gonadotropin regulation. 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