{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:54:10Z","timestamp":1773762850262,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"708","license":[{"start":{"date-parts":[[1984,10,1]],"date-time":"1984-10-01T00:00:00Z","timestamp":465436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,10,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hyperthyroidism and immune thrombocytopenia occurred concurrently in five patients; in a sixth, thyrotoxicosis developed after successful treatment of the thrombocytopenia. Correction of the hyperthyroidism was followed by a variable pattern of clinical response. In one case with mild asymptomatic thrombocytopenia spontaneous complete remission occurred. Two patients required adrenocorticosteroids to control severe thrombocytopenic purpura during the period of hyperthyroidism, after which complete remission occurred. Another patient with severe symptomatic thrombocytopenia remains with a partially compensated thrombocytolytic state but is without purpura and off all therapy. A fifth patient required splenectomy for drug-resistant thrombocytopenia and remains critically dependent on immunosuppressive therapy. The sixth patient had a relapse of immune thrombocytopenia with subsequent development of thyrotoxicosis but platelet count spontaneously returned to normal after correction of the hyperthyroidism. Pregnancy in two of these six patients was not associated with recurrence of either hyperthyroidism or thrombocytopenia.<\/jats:p><jats:p>Management of symptomatic purpura in adults with co-existent hyperthyroidism may differ from that customarily employed since adrenocorticosteroid therapy may need to be extended until euthyroidism has been established before proceeding to splenectomy. When surgery is necessary, the risk of thyrotoxic storm should be anticipated, and the patient appropriately premedicated.<\/jats:p>","DOI":"10.1136\/pgmj.60.708.657","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"657-661","source":"Crossref","is-referenced-by-count":9,"title":["Hyperthyroidism and immune thrombocytopenia"],"prefix":"10.1093","volume":"60","author":[{"given":"Peter","family":"Jacobs","sequence":"first","affiliation":[{"name":"University of Cape Town Leukaemia Centre Observatory, Cape"},{"name":"Department of Haematology, Groote Schuur Hospital , Observatory, Cape"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Majoos","sequence":"additional","affiliation":[{"name":"Department of Haematology, Groote Schuur Hospital , Observatory, Cape"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augustine","family":"Perrotta","sequence":"additional","affiliation":[{"name":"Michigan State University College of Osteopathic Medicine , Lansing, Michigan, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1984,10,1]]},"reference":[{"key":"ref_1","first-page":"224","article-title":"Measurements of concentrations of human serum immunoglobulins","volume":"1","author":"ANDERSON, S.G.; BANGHAM, D.R.; BATTY, I.; BECKER, W.; CINADER, B.; GIESSEN, V.A.N.D.E.R.; M., H.Y.M.E.S.; F., L.O.N.G.; D., P.E.E.T.O.O.M.; F., P.O.N.D.M.A.N.; K., R.A.Y.N.A.U.D.; M., R.E.I.M.E.R.; B., C.; ROWE, D.S.; SCHWICK, H.G.; VRANCHEVA, S.","year":"1933","unstructured":"ANDERSON, S.G., BANGHAM, D.R., BATTY, I., BECKER, W., CINADER, B., VAN DER GIESSEN, M., HYMES, F., LONG, D., PEETOOM, F., PONDMAN, K., RAYNAUD, M., REIMER, C.B., ROWE, D.S., SCHWICK, H.G. & VRANCHEVA, S. (1933) Measurements of concentrations of human serum immunoglobulins. European Journal of Immunology, 1, 224.","journal-title":"European Journal of Immunology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/ajcp\/76.3.289","article-title":"Mean platelet volume. The inverse relation of platelet size and count in normal subjects, and an artifact of other particles","volume":"76","author":"BESSMAN, J.D.; WILLIAMS, L.J.; GILMER, P.R.","year":"1981","unstructured":"BESSMAN, J.D., WILLIAMS, L.J. & GILMER, P.R. (1981) Mean platelet volume. The inverse relation of platelet size and count in normal subjects, and an artifact of other particles. American Journal of Clinical Pathology, 76, 289.","journal-title":"American Journal of Clinical Pathology"},{"key":"ref_3","first-page":"271","article-title":"Trephine biopsy of the bone marrow","volume":"64","author":"BIRD, A.R.; JACOBS, P.","year":"1983","unstructured":"BIRD, A.R. & JACOBS, P. (1983) Trephine biopsy of the bone marrow. South African Medical Journal, 64, 271.","journal-title":"South African Medical Journal"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.0954-6820.1979.tb06017.x","article-title":"Association of hyperthyroidism with idiopathic thrombocytopenic purpura and haemolytic anaemia","volume":"205","author":"BRANEHOG, I.; OLSSON, K.S.; WEINFELD, A.; DOMELLOF, L.","year":"1979","unstructured":"BRANEHOG, I., OLSSON, K.S., WEINFELD, A. & DOMELLOF, L. (1979) Association of hyperthyroidism with idiopathic thrombocytopenic purpura and haemolytic anaemia. Acta Medica Scandinavica, 205, 125.","journal-title":"Acta Medica Scandinavica"},{"key":"ref_5","article-title":"Immunodificiency and grouping with thyrogastric autoimmune disease in patients with chronic idiopathic thrombocytopenic purpura","author":"CLANCY, R.L.; MULLER, H.K.; WARD, H.A.","year":"1974","unstructured":"CLANCY, R.L., MULLER, H.K. & WARD, H.A. (1974) Immunodificiency and grouping with thyrogastric autoimmune disease in patients with chronic idiopathic thrombocytopenic purpura."},{"key":"ref_6","first-page":"243","article-title":"Australian and New Zealand","volume":"4","unstructured":"Australian and New Zealand Journal of Medicine, 4, 243.","journal-title":"Journal of Medicine"},{"key":"ref_7","article-title":"Thrombopenische purpura nach jodeinnahme","author":"DENNIG, H.","year":"1933","unstructured":"DENNIG, H. (1933) Thrombopenische purpura nach jodeinnahme."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM197501302920503","article-title":"Quantitative determination of antibody in idiopathic thrombocytopenic purpura: correlation of serum and platelet-bound antibody with clinical response","volume":"292","author":"DIXON, R.; ROSSE, W.; EBBERT, L.","year":"1975","unstructured":"DIXON, R., ROSSE, W. & EBBERT, L. (1975) Quantitative determination of antibody in idiopathic thrombocytopenic purpura: correlation of serum and platelet-bound antibody with clinical response. New England Journal of Medicine, 292, 230.","journal-title":"New England Journal of Medicine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00000441-197408000-00004","article-title":"Graves' disease and idiopathic thrombocytopenic purpura","volume":"268","author":"DUNLAP, D.B.; McFARLAND, K.F.; LUTCHER, C.L.","year":"1974","unstructured":"DUNLAP, D.B., McFARLAND, K.F. & LUTCHER, C.L. (1974) Graves' disease and idiopathic thrombocytopenic purpura. American Journal of the Medical Sciences, 268, 107.","journal-title":"American Journal of the Medical Sciences"},{"key":"ref_10","first-page":"342","article-title":"Hemochromatosis, thrombocytopenic purpura, and multiple endocrine disturbances. An unusual association of uncommon disorders is reported","volume":"63","author":"FRIEDLAND, M.L.; SCHAEFER, P.","year":"1980","unstructured":"FRIEDLAND, M.L. & SCHAEFER, P. (1980) Hemochromatosis, thrombocytopenic purpura, and multiple endocrine disturbances. An unusual association of uncommon disorders is reported. Rhode Island Medical Journal, 63, 342.","journal-title":"Rhode Island Medical Journal"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJM197101072840103","article-title":"Use of the megathrombocyte as an index of megakaryocyte number","volume":"284","author":"GARG, S.K.; AMOROSI, E.L.; KARPATKIN, S.","year":"1971","unstructured":"GARG, S.K., AMOROSI, E.L. & KARPATKIN, S. (1971) Use of the megathrombocyte as an index of megakaryocyte number. 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(1979) Tissue-specific autoimmune diseases in pregnancy. Clinics in Obstetrics and Gynecology, 6, 473.","journal-title":"Clinics in Obstetrics and Gynecology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000207396","article-title":"Thrombocytopenia in Graves' disease: effect of T3 on platelet kinetics","volume":"63","author":"KURATA, Y.; NISHIOEDA, Y.; TSUBAKIO, T.; KITANI, T.","year":"1980","unstructured":"KURATA, Y., NISHIOEDA, Y., TSUBAKIO, T. & KITANI, T. (1980). Thrombocytopenia in Graves' disease: effect of T3 on platelet kinetics. Acta Haematologica, 63, 185.","journal-title":"Acta Haematologica"},{"key":"ref_17","first-page":"222","article-title":"Radioimmunoassay of thyroxine, triiodothyroniine, and thyrotropin in human serum. Manual of Clinical Immunology","author":"LARSEN, P.R.","year":"1976","unstructured":"LARSEN, P.R. (1976) Radioimmunoassay of thyroxine, triiodothyroniine, and thyrotropin in human serum. 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(1981) Electronically determined platelet indices in thrombocytopenic patients. Cancer, 48, 954.","journal-title":"Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1097\/00007611-197812000-00038","article-title":"Immune thrombocytopenia, red cell aplasia, lupus, and hyperthyroidism","volume":"71","author":"OREN, M.E.; COHEN, M.S.","year":"1978","unstructured":"OREN, M.E. & COHEN, M.S. (1978) Immune thrombocytopenia, red cell aplasia, lupus, and hyperthyroidism. Southern Medical Journal, 71, 1577.","journal-title":"Southern Medical Journal"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"250","DOI":"10.7326\/0003-4819-87-2-250_2","article-title":"Graves' disease, myasthenia gravis, and purpura","volume":"87","author":"PINALS, R.S.; TOMAR, R.H.; HAAS, D.C.; FARAH, F.","year":"1977","unstructured":"PINALS, R.S., TOMAR, R.H., HAAS, D.C. & FARAH, F. (1977) Graves' disease, myasthenia gravis, and purpura. 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Archives of Internal Medicine, 139, 483.","journal-title":"Archives of Internal Medicine"},{"key":"ref_24","author":"ROWAN, R.M.; FRAZER, G.; GRAY, J.H.; McDONALD, G.A.","year":"1979","unstructured":"ROWAN, R.M., FRAZER, G., GRAY, J.H. & McDONALD, G.A. (1979)"},{"key":"ref_25","first-page":"2485","article-title":"Apathetic thyroid storm association with anasarca and thrombocytopenia","volume":"243","author":"SCHERMER, R.M.; MORLEY, J.E.; SHARP, B.; DANIELS, M.; HECT, H.; CARLSON, H.E.; HERSHMAN, J.M.","year":"1980","unstructured":"SCHERMER, R.M., MORLEY, J.E., SHARP, B., DANIELS, M., HECT, H., CARLSON, H.E. & HERSHMAN, J.M. (1980) Apathetic thyroid storm association with anasarca and thrombocytopenia. Journal of the American Medical Association, 243, 2485. SEGAL, B.M. & WEINTRAUB, M.I. (1976) Hashimoto's thyroiditis, myasthenia gravis, idiopathic thrombocytopenic purpura. Annals of Internal Medicine, 85, 761.","journal-title":"Journal of the American Medical Association; Hashimoto's thyroiditis, myasthenia gravis, idiopathic thrombocytopenic purpura"},{"key":"ref_26","article-title":"Protein electrophoresis. Chromatographic and Electrophoretic Techniques","volume":"2","author":"SMITH, I.","year":"1976","unstructured":"SMITH, I. (1976) Protein electrophoresis. Chromatographic and Electrophoretic Techniques. Vol 2. (Eds. I. Smith & J. W. T.","journal-title":"Vol"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/21548331.1981.11946739","article-title":"Autoimmune antireceptor diseases","volume":"16","author":"STOBO, J.D.","year":"1981","unstructured":"STOBO, J.D. (1981) Autoimmune antireceptor diseases. Hospital Practice, 16, 49.","journal-title":"Hospital Practice"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/00007611-197305000-00010","article-title":"Idiopathic thrombocytopenic purpura associated with hyperthyroidism","volume":"66","author":"MURAKAMI, M.","year":"1973","unstructured":"MURAKAMI, M. (1973) Idiopathic thrombocytopenic purpura associated with hyperthyroidism. Southern Medical Journal, 66, 553.","journal-title":"Southern Medical Journal"},{"key":"ref_29","first-page":"55","article-title":"Alterations in capillary fragility in thyroid disease","volume":"26","author":"THOMPSON, J.A.","year":"1964","unstructured":"THOMPSON, J.A. (1964) Alterations in capillary fragility in thyroid disease. Clinical Science, 26, 55.","journal-title":"Clinical Science"},{"key":"ref_30","first-page":"597","article-title":"Atypical hemorrhagic purpura occurring with toxic adenoma of the thyroid gland","volume":"6","author":"TOLAND, C.G.; ASKEY, J.M.","year":"1931","unstructured":"TOLAND, C.G. & ASKEY, J.M. (1931) Atypical hemorrhagic purpura occurring with toxic adenoma of the thyroid gland. Mayo Clinical Proceedings, 6, 597.","journal-title":"Mayo Clinical Proceedings"},{"key":"ref_31","first-page":"69","article-title":"Idiopathic thrombocytopenic purpura and Graves'","volume":"12","author":"VALENTA, L.J.; TREADWELL, T.; BERRY, R.; ELIAS, A.N.","year":"1932","unstructured":"VALENTA, L.J., TREADWELL, T., BERRY, R. & ELIAS, A.N. (1932) Idiopathic thrombocytopenic purpura and Graves' disease. American Journal of Hematology, 12, 69.","journal-title":"disease. American Journal of Hematology"},{"key":"ref_32","first-page":"97","article-title":"Hyperthyroidism in association with idiopathic thrombocytopenic purpura","volume":"58","author":"VANNASAENG, S.; WASI, P.; TANDHANAND, S.","year":"1975","unstructured":"VANNASAENG, S., WASI, P. & TANDHANAND, S. (1975) Hyperthyroidism in association with idiopathic thrombocytopenic purpura. 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