{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T19:21:55Z","timestamp":1698088915160},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"708","license":[{"start":{"date-parts":[[1984,10,1]],"date-time":"1984-10-01T00:00:00Z","timestamp":465436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,10,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The rate of endoscopically confirmed gastric ulcer relapse was compared in two groups of patients with newly healed benign gastric ulcers, receiving either cimetidine 400 mg nocte or matching placebo, over a period of 1 year. Six of 24 (25%) patients on cimetidine and 16 of 27 (59%) patients on placebo had endoscopically confirmed relapse. These included two patients in each group with asymptomatic relapses. The difference in the rate of relapse between the two groups was statistically significant (P = 0.01).<\/jats:p>","DOI":"10.1136\/pgmj.60.708.665","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"665-667","source":"Crossref","is-referenced-by-count":13,"title":["The effect of cimetidine on the maintenance of healing of gastric ulceration"],"prefix":"10.1093","volume":"60","author":[{"given":"J. D.","family":"Kinloch","sequence":"first","affiliation":[{"name":"Chase Farm Hospital , Enfield,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. G.","family":"Pearson","sequence":"additional","affiliation":[{"name":"Barnet General Hospital , Barnet"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. L.","family":"Woolf","sequence":"additional","affiliation":[{"name":"North Middlesex Hospital , Edmonton, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. H.","family":"Young","sequence":"additional","affiliation":[{"name":"Smith Kline & French Laboratories Ltd , Welwyn Garden City, Herts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1984,10,1]]},"reference":[{"key":"ref_1","first-page":"1098","article-title":"Cimetidine versus placebo in the treatment of benign gastric ulcer","volume":"80","author":"AKDAMAR, K.; DYCK, W.; ENGLERT, E.; BELSITO, A.; SONTAG, S.; VLAHCEVIC, Z.; STRICKLAND, R.; ACHORD, J.; GRAHAM, D.; KORNFIELD, R.; AGRAWAL, N.","year":"1981","unstructured":"AKDAMAR, K., DYCK, W., ENGLERT, E., BELSITO, A., SONTAG, S., VLAHCEVIC, Z., STRICKLAND, R., ACHORD, J., GRAHAM, D., KORNFIELD, R. & AGRAWAL, N. (1981) Cimetidine versus placebo in the treatment of benign gastric ulcer. Gastroenterology, 80, 1098.","journal-title":"Gastroenterology"},{"key":"ref_2","article-title":"A two-year prospective controlled study of maintenance cimetidine and gastric ulcer","author":"BARR, G.D.; KANG, J.Y.; CANALESE, J.; PIPER, D.W.","year":"1983","unstructured":"BARR, G.D., KANG, J.Y., CANALESE, J. & PIPER, D.W. (1983) A two-year prospective controlled study of maintenance cimetidine and gastric ulcer. Gastroenterology, 85, 100."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3109\/00365527909179865","article-title":"Prophylactic effect of cimetidine in gastric ulcer patients","volume":"14","author":"JENSEN, B.I.R.G.E.R.; K., M.O.L.L.M.A.N.; K-M., R.A.H.B.E.K.; I., R.A.S.K.-M.A.D.S.E.N.; J., R.U.N.E.; J., S.; WULFF, H.R.","year":"1979","unstructured":"BIRGER JENSEN, K., MOLLMAN, K-M., RAHBEK, I., RASK-MADSEN, J., RUNE, S.J. & WULFF, H.R. (1979) Prophylactic effect of cimetidine in gastric ulcer patients. Scandinavian Journal of Gastroenterology, 14, 175.","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0016-5085(78)90075-6","article-title":"Survival in peptic ulcer","volume":"75","author":"BONNEVIE, 0","year":"1978","unstructured":"BONNEVIE, 0. (1978) Survival in peptic ulcer. Gastroenterology, 75, 1055.","journal-title":"Gastroenterology"},{"key":"ref_5","first-page":"102","article-title":"Maintenance treatment of duodenal and gastric ulcer with ranitidine","volume":"20","author":"BOYD, E.J.S.; WILSON, J.A.; WORMSLEY, K.G.","year":"1982","unstructured":"BOYD, E.J.S., WILSON, J.A. & WORMSLEY, K.G. (1982) Maintenance treatment of duodenal and gastric ulcer with ranitidine. In: Ranitidine: Proceedings of an international symposium held in the context of the Seventh World Congress of Gastroenterololy (Eds. A. J. Riley and P. R. Salmon), p. 102. Excerpta Medica, Amsterdam. CICLITIRA, P.J., MACHELL, RJ., FARTHING, M.J.G., DICK, A.P. & HUNTER, J.O. (1979) Double-blind controlled trial of cimetidine in the healing of gastric ulcer. Gut, 20, 730.","journal-title":"Ranitidine: Proceedings of an international symposium held in the context of the Seventh World Congress of Gastroenterololy; Gut; Double-blind controlled trial of cimetidine in the healing of gastric ulcer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1445-5994.1980.tb04095.x","article-title":"Effects of cimetidine on the healing of benign gastric ulcers","volume":"10","author":"CLARKE, A.C.; LEE, S.P.; TASMAN-JONES, C.","year":"1980","unstructured":"CLARKE, A.C., LEE, S.P. & TASMAN-JONES, C. (1980) Effects of cimetidine on the healing of benign gastric ulcers. Australian and New Zealand Journal of Medicine, 10, 430.","journal-title":"Australian and New Zealand Journal of Medicine"},{"key":"ref_7","first-page":"287","article-title":"Treatment of gastric ulcer by cimetidine","volume":"2","author":"TRIAL, F.R.E.N.C.H.M.U.L.T.I.C.E.N.T.R.E.","year":"1977","unstructured":"FRENCH MULTICENTRE TRIAL (1977) Treatment of gastric ulcer by cimetidine. In: Proceedings of the Second International Symposium on Histamine H2-Receptor Antagonists (Eds. W. L. Burland & M. A. Simkins), p. 287. Excerpta Medica, Amsterdam. FROST, F., RAHBECK, I., RUNE, S.J., BIRGER-JENSEN, K., GUDMANHOYER, E., KRAG, E., RASK-MADSEN, J., WULFF, H.R., GARBOL, J., GOTLIEB JENSEN, K., HOJLUND, M. & NISSEN, V.R. (1977) Cimetidine in patients with gastric ulcer: a multicentre controlled trial. British Medical Journal, 2, 795.","journal-title":"Proceedings of the Second International Symposium on Histamine H2-Receptor Antagonists; British Medical Journal; Cimetidine in patients with gastric ulcer: a multicentre controlled trial"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0016-5085(19)33459-6","article-title":"The follow-up period","volume":"61","author":"HANSCOM, D.H.; BUCHMAN, E.","year":"1971","unstructured":"HANSCOM, D.H. & BUCHMAN, E. (1971) The follow-up period. Gastroenterology, 61, 585.","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1136\/gut.24.9.853","article-title":"Effect of cimetidine treatment in the prevention of gastric ulcer relapse: a one year double blind multicentre study","volume":"24","author":"HENTSCHEL, E.; SCHULZE, J.; WEISS, W.; RUDIGER, E.; JUDMAIR, G.; REICHEL, W.; KERSTAN, E.; HORTON, J.","year":"1983","unstructured":"HENTSCHEL, E., SCHULZE, J., WEISS, W., RUDIGER, E., JUDMAIR, G., REICHEL, W., KERSTAN, E. & HORTON, J. (1983) Effect of cimetidine treatment in the prevention of gastric ulcer relapse: a one year double blind multicentre study. Gut, 24, 853.","journal-title":"Gut"},{"key":"ref_10","first-page":"\"8","article-title":"Cimetidine in the maintenance of treatment of gastric ulceration. Hepatogastroenterology (Suppi) XI International Congress of Gastroenterology","volume":"2","author":"BROOY, L.A.; J., S.; TAYLOR, R.H.; AYRTON, C.; GOLDING, P.L.; COLIN-JONES, D.G.; HUNT, R.H.; MILTON-THOMPSON, G.J.; MISIEWICZ, J.J.","year":"1980","unstructured":"LA BROOY, S.J., TAYLOR, RH., AYRTON, C., GOLDING, P.L., COLIN-JONES, D.G., HUNT, R.H., MILTON-THOMPSON, G.J. & MISIEWICZ, J.J. (1980) Cimetidine in the maintenance of treatment of gastric ulceration. Hepatogastroenterology (Suppi) XI International Congress of Gastroenterology, Hamburg, July 8-13, 1980 p. 205, Abstr. E26.5 LANDECKER, K.D., CRAWFORD, J., HUNT, J.H., GILLESPIE, P. & PIPER, D.W. (1979) Cimetidine and gastric ulcer healing: a double-blind controlled trial. Medical Journal of Australia, 2, 43.","journal-title":"Medical Journal of Australia; Abstr. E26.5 LANDECKER"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1136\/pgmj.55.644.393","article-title":"Cimetidine in the prevention ofgastric ulcer relapse","volume":"55","author":"MACHELL, R.J.; CICLITIRA, P.J.; FARTHING, M.J.G.; DICK, A.P.; HUNTER, J.O.","year":"1979","unstructured":"MACHELL, RJ., CICLITIRA, P.J., FARTHING, M.J.G., DICK, A.P. & HUNTER, J.O. (1979) Cimetidine in the prevention ofgastric ulcer relapse. Postgraduate Medical Journal, 55, 393.","journal-title":"Postgraduate Medical Journal"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1136\/bmj.2.6148.1323","article-title":"Cimetidine an advance in gastric ulcer treatment?","volume":"2","author":"MORGAN, A.G.; MCADAM, W.A.F.; PACSOO, C.; WALKER, B.E.; SIMMONS, A.V.","year":"1978","unstructured":"MORGAN, A.G., MCADAM, W.A.F., PACSOO, C., WALKER, B.E. & SIMMONS, A.V. (1978) Cimetidine an advance in gastric ulcer treatment? British Medical Journal, 2, 1323.","journal-title":"British Medical Journal"},{"key":"ref_13","first-page":"1002","article-title":"Results of a two-year maintenance study ofgastric ulcer disease","volume":"24","author":"MORGAN, A.G.; MCADAM, W.A.F.; PACsoo, C.; DARBOROUGH, A.","year":"1983","unstructured":"MORGAN, A.G., MCADAM, W.A.F., PACsoo, C. & DARBOROUGH, A. (1983) Results of a two-year maintenance study ofgastric ulcer disease. Gut, 24, A1002.","journal-title":"Gut"},{"key":"ref_14","article-title":"Gastric cancer and cimetidine: does delay in diagnosis matter?","volume":"630","author":"SCOTCHER, S.; SIKORA, K.; FREEDMAN, L.","year":"1981","unstructured":"SCOTCHER, S., SIKORA, K. & FREEDMAN, L. (1981) Gastric cancer and cimetidine: does delay in diagnosis matter? Lancet, ii, 630.","journal-title":"Lancet"},{"key":"ref_15","article-title":"Accepted I","year":"1984","unstructured":"(Accepted I May 1984)"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/60\/708\/665\/50202200\/postgradmedj-60-665.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/60\/708\/665\/50202200\/postgradmedj-60-665.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T08:02:39Z","timestamp":1683273759000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/60\/708\/665\/7048187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,10,1]]},"references-count":15,"journal-issue":{"issue":"708","published-online":{"date-parts":[[1984,10,1]]},"published-print":{"date-parts":[[1984,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.60.708.665","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1984,10]]},"published":{"date-parts":[[1984,10,1]]}}}