{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:16:56Z","timestamp":1759483016214},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"708","license":[{"start":{"date-parts":[[1984,10,1]],"date-time":"1984-10-01T00:00:00Z","timestamp":465436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,10,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A patient with severe pulmonary hypertension due to pulmonary arteriolar obliteration complicating a long standing CREST variant of systemic sclerosis showed improvement in cardiac output and exercise tolerance during treatment with captopril, which was discontinued because of persistent systemic hypotension.<\/jats:p>\n               <jats:p>It is suggested that captopril would have a useful and possible prophylactic effect early in pulmonary hypertension in systemic sclerosis.<\/jats:p>","DOI":"10.1136\/pgmj.60.708.672","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"672-674","source":"Crossref","is-referenced-by-count":9,"title":["The CREST syndrome\u2014successful reduction of pulmonary hypertension by captopril"],"prefix":"10.1093","volume":"60","author":[{"given":"P. J.","family":"Prouse","sequence":"first","affiliation":[{"name":"Departments of Rheumatology, Northwick Park Hospital , Harrow, Middlesex HA1 3UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lahiri","sequence":"additional","affiliation":[{"name":"Departments of Cardiology, Northwick Park Hospital , Harrow, Middlesex HA1 3UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Gumpel","sequence":"additional","affiliation":[{"name":"Departments of Rheumatology, Northwick Park Hospital , Harrow, Middlesex HA1 3UT"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1984,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.ph.42.030180.001253","article-title":"Humoral control of the pulmonary circulation","volume":"42","author":"BERGOFSKY, E.H.","year":"1980","unstructured":"BERGOFSKY, E.H. (1980) Humoral control of the pulmonary circulation. Annual Review of Physiology, 42, 221.","journal-title":"Annual Review of Physiology"},{"key":"ref_2","first-page":"788","article-title":"The microvascular pathogenesis of scieroderma: an hypothesis","volume":"81","author":"FRIES, J.F.","year":"1979","unstructured":"FRIES, J.F. (1979) The microvascular pathogenesis of scieroderma: an hypothesis. Annals of Internal Medicine, 81, 788.","journal-title":"Annals of Internal Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/pgmj.57.664.115","article-title":"Effects ofcaptopril (S. Q. 14,225) in a patient with primary pulmonary hypertension","volume":"57","author":"HOROWITZ, J.D.; OLIVER, L.E.; GOBLE, A.J.; BRENNAN, J.B.; HARD-ING, D.; Louis, W.J.","year":"1981","unstructured":"HOROWITZ, J.D., OLIVER, L.E., GOBLE, A.J., BRENNAN, J.B., HARD-ING, D. & Louis, W.J. (1981) Effects ofcaptopril (S.Q. 14,225) in a patient with primary pulmonary hypertension. 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(1979) Effects of the converting enzyme inhibitor (S.Q. 20881) on the pulmonary circulation in man. American Journal of Medicine, 67, 785.","journal-title":"American Journal of Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.7326\/0003-4819-86-4-394","article-title":"Pulmonary hypertension in the CREST syndrome variant of progressive systemic sclerosis (scleroderma)","volume":"86","author":"SALERNI, R.; RODNAN, G.P.; LEON, D.F.; SHAVER, J.A.","year":"1977","unstructured":"SALERNI, R., RODNAN, G.P., LEON, D.F. & SHAVER, J.A. (1977) Pulmonary hypertension in the CREST syndrome variant of progressive systemic sclerosis (scleroderma). Annals of Internal Medicine, 86, 394.","journal-title":"Annals of Internal Medicine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0002-9149(80)90655-4","article-title":"Comparative hemodynamic effects of converting enzyme inhibitor and sodium nitroprusside in severe heart failure","volume":"45","author":"VROBEL, T.R.; COHN, J.N.","year":"1980","unstructured":"VROBEL, T.R. & COHN, J.N. (1980) Comparative hemodynamic effects of converting enzyme inhibitor and sodium nitroprusside in severe heart failure. American Journal of Cardiology, 45, 331.","journal-title":"American Journal of Cardiology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/0002-9343(78)90455-2","article-title":"Pulmonary vascular changes in scleroderma","volume":"64","author":"YOUNG, R.H.; MARK, G.J.","year":"1978","unstructured":"YOUNG, R.H. & MARK, G.J. (1978) Pulmonary vascular changes in scleroderma. 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