{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T14:22:30Z","timestamp":1746541350394},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"708","license":[{"start":{"date-parts":[[1984,10,1]],"date-time":"1984-10-01T00:00:00Z","timestamp":465436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,10,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The case history of a 34-year-old patient with precirrhotic idiopathic haemochromatosis and severe chronic steatorrhoea is presented. The pancreas had a normal appearance on ultrasonography and endoscopic retrograde pancreaticography. However, pancreatic function tests revealed significant abnormalities. The pancreatic output of trypsin, amylase, lipase and bicarbonate was deficient and basal and stimulated serum pancreatic polypeptide levels were subnormal. In contrast, the oral glucose tolerance test was unimpaired. The pancreatic insufficiency had started suddenly during a summer vacation and may have had a viral aetiology. The hypothesis is advanced that in haemochromatosis the iron-laden pancreatic acinar and PP-producing cells are more susceptible to damage by viruses than normal pancreatic cells.<\/jats:p>","DOI":"10.1136\/pgmj.60.708.675","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"675-678","source":"Crossref","is-referenced-by-count":7,"title":["Exocrine pancreatic insufficiency and idiopathic haemochromatosis"],"prefix":"10.1093","volume":"60","author":[{"given":"P. L. M.","family":"Jansen","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gastrointestinal and Liver Diseases, St Radboud Hospital, University of Nijmegen , Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Thien","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Radboud Hospital, University of Nijmegen , Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. B.","family":"Lamers","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastrointestinal and Liver Diseases, St Radboud Hospital, University of Nijmegen , Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H.","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastrointestinal and Liver Diseases, St Radboud Hospital, University of Nijmegen , Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Reekers","sequence":"additional","affiliation":[{"name":"Blood Transfusion Service, St Radboud Hospital, University of Nijmegen , Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Strijk","sequence":"additional","affiliation":[{"name":"Department of Radiology, St Radboud Hospital, University of Nijmegen , Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1984,10,1]]},"reference":[{"key":"ref_1","first-page":"553","article-title":"Haemochromatosis. Investigation of twenty-three cases, with special reference to etiology, nutrition, iron metabolism and studies of hepatic and pancreatic function","volume":"88","author":"ALTHAUSEN, T.L.; DoIG, R.K.; WEIDEN, S.; MOTTERAM, R.; TURNER, C.M.; MOORE, A.","year":"1951","unstructured":"ALTHAUSEN, T.L., DoIG, R.K., WEIDEN, S., MOTTERAM, R., TURNER, C.M. & MOORE, A. (1951) Haemochromatosis. Investigation of twenty-three cases, with special reference to etiology, nutrition, iron metabolism and studies of hepatic and pancreatic function. Achives of Internal Medicine, 88, 553.","journal-title":"Achives of Internal Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1056\/NEJM197904263001708","article-title":"Case 17-1979","volume":"300","author":"AXELROD, L.; FERRUCCI, J.T.; VICKERY, A.L.","year":"1979","unstructured":"AXELROD, L., FERRUCCI, J.T. & VICKERY, A.L. (1979) Case 17-1979. 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