{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T11:59:30Z","timestamp":1715687970545},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"708","license":[{"start":{"date-parts":[[1984,10,1]],"date-time":"1984-10-01T00:00:00Z","timestamp":465436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,10,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A case of severe hypokalaemia with stupor, skeletal muscle and heart muscle damage is reported.<\/jats:p>\n               <jats:p>An initial infusion of glucose-insulin and potassium (GIK) produced a temporary clinical improvement with reduction of creatine kinase (CKMB) and elevation of serum K+. On the 4th day of treatment, neuromuscular and cardiovascular deterioration occurred accompanied by a further rise of CKMB. This deterioration was coincident with a serum phosphate of 0.26 mmol\/l. The impaired left ventricular (LV) function was measured using echocardiography and detecting the ejection fraction (EF).<\/jats:p>\n               <jats:p>GIK was stopped and a potassium phosphate infusion commenced. As the phosphate and potassium deficiencies were corrected, the neuromuscular and cardiac abnormalities resolved, CKMB fell to normal and LVEF rose from 40% to 72%.<\/jats:p>\n               <jats:p>We suggest that additional cardiac damage due to hypophosphataemia may have occurred in this patient, who already had cardiac impairment as a result of profound hypokalaemia. Possible mechanisms are discussed.<\/jats:p>","DOI":"10.1136\/pgmj.60.708.679","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"679-681","source":"Crossref","is-referenced-by-count":10,"title":["Myocardial damage due to hypokalaemia and hypophosphataemia"],"prefix":"10.1093","volume":"60","author":[{"given":"Andrea","family":"Frustaci","sequence":"first","affiliation":[{"name":"Department of Cardiology, Catholic University , Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faustino","family":"Pennestr\u00ec","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catholic University , Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciriaco","family":"Scoppetta","sequence":"additional","affiliation":[{"name":"Department of Neurology, Catholic University , Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1984,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1001\/archinte.1977.03630140051013","article-title":"The pathophysiology and clinical characteristics of severe hypophosphataemia","volume":"137","author":"KNOCHEL, J.P.","year":"1977","unstructured":"KNOCHEL, J.P. (1977) The pathophysiology and clinical characteristics of severe hypophosphataemia. Archives ofInternal Medicine, 137, 203.","journal-title":"Archives ofInternal Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0002-8703(81)90303-3","article-title":"Clinical effects of glucose-insulin-potassium on left ventricular function in acute myocardial infarction: results from a randomized clinical trial","volume":"102","author":"MANTLE, J.A.; ROGERS, W.J.; SMITH, L.R.; McDANIEL, H.G.; PAPAPIETRO, S.E.; RUSSEL, R.O.; RACKLEY, C.E.","year":"1981","unstructured":"MANTLE, J.A., ROGERS, W.J., SMITH, L.R., McDANIEL, H.G., PAPAPIETRO, S.E., RUSSEL, R.O. & RACKLEY, C.E. (1981) Clinical effects of glucose-insulin-potassium on left ventricular function in acute myocardial infarction: results from a randomized clinical trial. American Heart Journal, 102, 313.","journal-title":"American Heart Journal"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1056\/NEJM197710272971702","article-title":"Effect of hypophosphatemia on myocardial performance in man","volume":"297","author":"R., O.'C.O.N.N.O.R.L.; S., W.H.E.E.L.E.R.W.; BETHUNE, J.E.","year":"1977","unstructured":"O'CONNOR L.R., WHEELER W.S. & BETHUNE, J.E. (1977) Effect of hypophosphatemia on myocardial performance in man. New England Journal of Medicine, 297, 901.","journal-title":"New England Journal of Medicine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/0002-9149(77)90051-0","article-title":"Cardiomyopathy in an adult with Bartter's syndrome and hypokalemia","volume":"40","author":"PoTTs, J.K.; PALAKOS, T.G.; STREETEN, D.H.P.; JONES, D.","year":"1977","unstructured":"PoTTs, J.K., PALAKOS, T.G., STREETEN, D.H.P. & JONES, D. (1977) Cardiomyopathy in an adult with Bartter's syndrome and hypokalemia. American Journal of Cardiology, 40, 995.","journal-title":"American Journal of Cardiology"},{"key":"ref_5","article-title":"Accepted 5","year":"1983","unstructured":"(Accepted 5 October 1983)"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/60\/708\/679\/50202164\/postgradmedj-60-679.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/60\/708\/679\/50202164\/postgradmedj-60-679.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T07:59:23Z","timestamp":1683273563000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/60\/708\/679\/7048156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,10,1]]},"references-count":5,"journal-issue":{"issue":"708","published-online":{"date-parts":[[1984,10,1]]},"published-print":{"date-parts":[[1984,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.60.708.679","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1984,10]]},"published":{"date-parts":[[1984,10,1]]}}}