{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T19:56:07Z","timestamp":1776542167121,"version":"3.51.2"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"713","license":[{"start":{"date-parts":[[1985,3,1]],"date-time":"1985-03-01T00:00:00Z","timestamp":478483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,3,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We have used a combination of a beta-blocker and verapamil to treat 42 consecutive patients with angina resistant to either agent alone. Patients with heart failure, heart block or uncontrolled hypertension were excluded. The mean duration of follow-up was 6.5 months. Thirty-six patients (81%) reported an improvement and the number of angina attacks was reduced from 17\/week to 5\/week. Side effects necessitated withdrawal of one or both drugs in 6 patients, 2 of whom developed bradyarrhythmias not solely related to drug treatment. The most common complication was mild left ventricular failure (6) treated by reducing or stopping the beta-blocker. The data suggest that the combination of verapamil and a beta-blocker may be used in a relatively unselected group of patients with difficult angina. However, as dosage adjustment and close observation may be necessary to minimise side effects, the use of this combination should be limited to hospital practice.<\/jats:p>","DOI":"10.1136\/pgmj.61.713.229","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"229-232","source":"Crossref","is-referenced-by-count":9,"title":["Tolerability of combined treatment with verapamil and beta-blockers in angina resistant to monotherapy"],"prefix":"10.1093","volume":"61","author":[{"given":"J C","family":"McGourty","sequence":"first","affiliation":[{"name":"The Hypertension Unit, Clatterbridge Hospital , Bebington, Merseyside L63 4JY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Silas","sequence":"additional","affiliation":[{"name":"The Hypertension Unit, Clatterbridge Hospital , Bebington, Merseyside L63 4JY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S A","family":"Solomon","sequence":"additional","affiliation":[{"name":"The Hypertension Unit, Clatterbridge Hospital , Bebington, Merseyside L63 4JY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1985,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1136\/bmj.281.6250.1251-a","article-title":"Nifedipine and beta-blocking drugs","volume":"281","author":"ANASTASSIADES, C.J.","year":"1980","unstructured":"ANASTASSIADES, C.J. (1980). Nifedipine and beta-blocking drugs. British Medical Journal, 281, 1251.","journal-title":"British Medical Journal"},{"key":"ref_2","first-page":"1173","article-title":"An objective double-blind placebo-controlled comparison of nifedipine and verapamil","volume":"50","author":"SUBRAMANIAN, B.A.L.A.; V., B.O.W.L.E.S.; J., M.; KHURMI, M.S.; DAVIES, A.B.; RAFTERY, E.B.","year":"1982","unstructured":"BALA SUBRAMANIAN, V., BOWLES, M.J., KHURMI, M.S., DAVIES, A.B. & RAFTERY, E.B. (1982a). An objective double-blind placebo-controlled comparison of nifedipine and verapamil. American Journal of Cardiology, 50, 1173.","journal-title":"American Journal of Cardiology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0002-9149(82)90286-7","article-title":"Combined therapy with verapamil and propranolol in chronic stable angina","volume":"49","author":"SUBRAMANIAN, B.A.L.A.; BOWLES, V.; J., M.; DAVIES, A.B.; RAFTERY, E.B.","year":"1982","unstructured":"BALA SUBRAMANIAN, V. BOWLES, M.J., DAVIES, A.B. & RAFTERY, E.B. (1982b). Combined therapy with verapamil and propranolol in chronic stable angina. American Journal of Cardiology, 49, 125.","journal-title":"American Journal of Cardiology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1136\/bmj.284.6322.1067","article-title":"Additive anti-anginal effects of verapamil in patients receiving propranolol","volume":"284","year":"1982","unstructured":"BASSAN, M., WEILER-RAVELL, D. & SHALEV, 0. (1982). Additive anti-anginal effects of verapamil in patients receiving propranolol. British Medical Journal, 284, 1067.","journal-title":"British Medical Journal"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1136\/bmj.286.6376.1467","article-title":"Treatment of angina pectoris with nifedipine; importance of dose titration","volume":"6","author":"DEANFIELD, J.; WRIGHT, C.; FOX, K.","year":"1983","unstructured":"DEANFIELD, J., WRIGHT, C. & FOX, K. (1983). Treatment of angina pectoris with nifedipine; importance of dose titration. British Medical Journal, 6, 1467.","journal-title":"British Medical Journal"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1161\/01.CIR.38.2.432","article-title":"Prognosis of men with coronary heart disease as related to blood pressure","volume":"38","author":"FRANK, C.W.; WEINBLATT, E.; SHAPIRO, S.; SAGAR, R.C.","year":"1968","unstructured":"FRANK, C.W., WEINBLATT, E., SHAPIRO, S. & SAGAR, R.C. (1968). Prognosis of men with coronary heart disease as related to blood pressure. Circulation, 38, 432.","journal-title":"Circulation"},{"issue":"2","key":"ref_7","first-page":"62","article-title":"Calcium antagonists and beta-blockade - a useful combination","volume":"59","author":"GEDDES, J.S.","year":"1983","unstructured":"GEDDES, J.S. (1983). Calcium antagonists and beta-blockade - a useful combination. Postgraduate Medical Journal, 59, (Suppl. 2), 62.","journal-title":"Postgraduate Medical Journal"},{"key":"ref_8","first-page":"279","article-title":"The effect of hypertension and its prognosis after myocardial infarction","volume":"71","author":"GRAHAM, I.M.; MULCAHY, R.; HICKEY, N.; DALY, L.","year":"1978","unstructured":"GRAHAM, I.M., MULCAHY, R., HICKEY, N. & DALY, L. (1978). The effect of hypertension and its prognosis after myocardial infarction. In Hjalmarson A, Wilhelmsen L, eds. Acute and long-term medical management of myocardial ischaemia. p. 279. Molndal: Lindgren and Siner. JOHNSON, S.M., MAURITSON, D.R., CORBETT, J.R., WOODWARD, W., WILLERSON, J. & HILLIS, L.D. (1981). Doubleblind randomised placebo controlled comparison of propranolol and verapamil in the treatment of patients with stable angina pectoris. American Journal ofMedicine, 71, 443.","journal-title":"American Journal ofMedicine; long-term medical management of myocardial ischaemia"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1136\/hrt.45.4.457","article-title":"Nifedipine and left ventricular function in beta-blocked patients","volume":"45","author":"HENDERSON, A.H.","year":"1981","unstructured":"HENDERSON, A.H., (1981). Nifedipine and left ventricular function in beta-blocked patients. British Heart Journal, 45, 457.","journal-title":"British Heart Journal"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/01.CIR.65.4.653","article-title":"The effects of intravenous verapamil on haemodynamic status ofpatients with coronary artery disease receiving propranolol","volume":"65","author":"KIEVAL, J.; KIRSTEN, E.B.; KESSLER, K.M.; MALLON, S.M.; MYERBURG, R.J.","year":"1982","unstructured":"KIEVAL, J., KIRSTEN, E.B., KESSLER, K.M., MALLON, S.M. & MYERBURG, R.J. (1982). The effects of intravenous verapamil on haemodynamic status ofpatients with coronary artery disease receiving propranolol. Circulation, 65, 653.","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0002-9149(81)90582-8","article-title":"Clinical efficacy of verapamil alone and combined with propranolol in treating patients with chronic stable angina","volume":"48","author":"EPSTEIN, S.E.","year":"1981","unstructured":"EPSTEIN, S.E. (1981). Clinical efficacy of verapamil alone and combined with propranolol in treating patients with chronic stable angina. American Journal ofCardiology, 48, 131.","journal-title":"American Journal ofCardiology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/00012995-198108000-00001","article-title":"Adverse effects of calcium antagnoists","volume":"89","author":"LEWIS, J.G.","year":"1981","unstructured":"LEWIS, J.G., (1981). Adverse effects of calcium antagnoists. Adverse Drug Reaction Bulletin, 89, 324.","journal-title":"Adverse Drug Reaction Bulletin"},{"key":"ref_13","first-page":"375","article-title":"Double-blind evaluation ofverapamil, propranolol and isosorbide dinitrate against a placebo in the treatment of angina pectoris","volume":"3","author":"LIVESELEY, B.; CATLEY, P.F.; CAMPBELL, R.C.; ORAM, S.","year":"1973","unstructured":"LIVESELEY, B., CATLEY, P.F., CAMPBELL, R.C. & ORAM, S. (1973). Double-blind evaluation ofverapamil, propranolol and isosorbide dinitrate against a placebo in the treatment of angina pectoris. British Medical Journal, 3, 375.","journal-title":"British Medical Journal"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1136\/bmj.281.6234.184","article-title":"A double-blind comparison ofpropranolol, nifedipine and their combination","volume":"281","author":"LYNCH, P.; DARGIE, H.; KRIKLER, S.; KRIKLER, D.","year":"1980","unstructured":"LYNCH, P., DARGIE, H., KRIKLER, S. & KRIKLER, D. (1980). A double-blind comparison ofpropranolol, nifedipine and their combination. British Medical Journal, 281, 184.","journal-title":"British Medical Journal"},{"key":"ref_15","article-title":"Drugs and the heart-III-calcium antagonists","volume":"806","author":"OPIE, L.H.","year":"1980","unstructured":"OPIE, L.H. (1980a). Drugs and the heart-III-calcium antagonists. Lancet, i, 806.","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1136\/bmj.281.6253.1462","article-title":"Adverse interaction between nifedipine and beta-blockade","volume":"281","author":"OPIE, L.H.; WHITE, D.A.","year":"1980","unstructured":"OPIE, L.H. & WHITE, D.A. (1980b). Adverse interaction between nifedipine and beta-blockade. British Medical Journal, 281, 1462.","journal-title":"British Medical Journal"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/0002-9149(82)91252-8","article-title":"Haemodynamic and clinical effects ofcombined verapamil and propranolol therapy in angina pectoris","volume":"50","author":"PACKER, M.; LEON, M.B.; BONOW, R.O.; KIEVAL, J.; ROS-ING, D.R.; SUBRAMANIAN, B.A.L.A.; V.","year":"1982","unstructured":"PACKER, M., LEON, M.B., BONOW, R.O., KIEVAL, J., ROS-ING, D.R. & BALA SUBRAMANIAN, V. (1982a). Haemodynamic and clinical effects ofcombined verapamil and propranolol therapy in angina pectoris. American Journal of Cardiology, 50, 903.","journal-title":"American Journal of Cardiology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/01.CIR.65.4.660","article-title":"Haemodynamic consequences of combined beta-adrenergic and slow calcium channel blockade in man","volume":"65","author":"PACKER, M.; MELLER, J.; MEDINA, N.; YUSHAK, M.; SMITH, H.; HOLT, J.; GUERERRO, J.; TODD, G.D.; RUS-SELL, B.S.; McALLISTER, G.; GORLIN, R.","year":"1982","unstructured":"PACKER, M., MELLER, J., MEDINA, N., YUSHAK, M., SMITH, H., HOLT, J., GUERERRO, J., TODD, G.D., RUS-SELL, B.S., McALLISTER, G. & GORLIN, R. (1982b). Haemodynamic consequences of combined beta-adrenergic and slow calcium channel blockade in man. Circulation, 65, 660.","journal-title":"Circulation"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/61\/713\/229\/50155754\/postgradmedj-61-229.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/61\/713\/229\/50155754\/postgradmedj-61-229.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T12:20:39Z","timestamp":1683202839000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/61\/713\/229\/7046820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3,1]]},"references-count":18,"journal-issue":{"issue":"713","published-online":{"date-parts":[[1985,3,1]]},"published-print":{"date-parts":[[1985,3,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.61.713.229","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1985,3]]},"published":{"date-parts":[[1985,3,1]]}}}