{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:35:09Z","timestamp":1792445709178,"version":"4.5.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"714","license":[{"start":{"date-parts":[[1985,4,1]],"date-time":"1985-04-01T00:00:00Z","timestamp":481161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Thirty-one patients with radiolucent common bile duct stones received medical treatment. Nineteen had Rowachol, a terpene preparation, eight (42%) achieving complete stone disappearance within 3 to 48 months. Fifteen (including 3 of the above) took Rowachol with bile acid (chenodeoxycholic in 11, ursodeoxycholic in 4) for 3 to 60 months: 11 (73%) achieved complete dissolution within 18 months. Persistent symptoms and complications settled on conservative management: 8 (25%) patients required admission (2 biliary colic, 1 obstructive jaundice, 4 cholangitis, 1 pancreatitis). One patient died of a myocardial infarction during recovery from pancreatitis; the other continued treatment, 2 achieving complete dissolution\/disappearance. Oral dissolution therapy with Rowachol and bile acids should be considered when endoscopic sphincterotomy or surgery is not feasible, but careful attention to potential complications is required while stones persist.<\/jats:p>","DOI":"10.1136\/pgmj.61.714.313","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"313-316","source":"Crossref","is-referenced-by-count":27,"title":["Stones in the common bile duct: experience with medical dissolution therapy"],"prefix":"10.1093","volume":"61","author":[{"given":"K W","family":"Somerville","sequence":"first","affiliation":[{"name":"Department of Therapeutics, University Hospital , Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W R","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Therapeutics, University Hospital , Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B H","family":"Whitten","sequence":"additional","affiliation":[{"name":"Department of Therapeutics, University Hospital , Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T W","family":"Balfour","sequence":"additional","affiliation":[{"name":"Department of Surgery, City Hospital , Nottingham NG5 1PB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G D","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Therapeutics, University Hospital , Nottingham NG7 2UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1985,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/BF01393771","article-title":"Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis","volume":"27","author":"BACHRACH, W.H.; HOFMANN, A.F.","year":"1982","unstructured":"BACHRACH, W.H. & HOFMANN, A.F. (1982). Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Digestive Diseases and Sciences, 27, 737 and 833.","journal-title":"Digestive Diseases and Sciences"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000197933","article-title":"The medical treatment of cholesterol gall stones: experience with chenodeoxycholic acid","volume":"14","author":"BARBARA, L.; RODA, E.; RODA, A.; SAMA, C.; FESTI, D.; MAZZELLA, G.; ALDINI, R.","year":"1976","unstructured":"BARBARA, L., RODA, E., RODA, A., SAMA, C., FESTI, D., MAZZELLA, G. & ALDINI, R. (1976). The medical treatment of cholesterol gall stones: experience with chenodeoxycholic acid. Digestion, 14, 209.","journal-title":"Digestion"},{"key":"ref_3","first-page":"1111","article-title":"Comparison of fixed doses of chenodeoxycholic acid for gall stone dissolution","volume":"i,","author":"BATESON, M.C.; ROSS, P.E.; MURISON, J.; BOUCHIER, I.A.D.","year":"1978","unstructured":"BATESON, M.C., ROSS, P.E., MURISON, J. & BOUCHIER, I.A.D. (1978). Comparison of fixed doses of chenodeoxycholic acid for gall stone dissolution. Lancet, i, 1111.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1136\/bmj.286.6367.778","article-title":"Gall stone dissolving agents","volume":"286","author":"BOUCHIER, I.A.D.","year":"1983","unstructured":"BOUCHIER, I.A.D. (1983). Gall stone dissolving agents. 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