{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:46Z","timestamp":1761058906450},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"714","license":[{"start":{"date-parts":[[1985,4,1]],"date-time":"1985-04-01T00:00:00Z","timestamp":481161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Two patients presented with hypophosphataemic osteomalacia and were subsequently found to have small tumours unusual histopathology and location causing the osteomalacia. Each tumour was found after an intensive search for occult masses. Studies of vitamin D metabolism and renal tubular function before and after surgery yielded further insight into the pathophysiology of oncogenic osteomalacia. These cases demonstrate that microscopic quantities of tumour are capable of causing the syndrome and further illustrate the high index of suspicion often necessary to locate causative tumours in patients with hypophosphataemic osteomalacia.<\/jats:p>","DOI":"10.1136\/pgmj.61.714.349","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"349-355","source":"Crossref","is-referenced-by-count":28,"title":["Oncogenic osteomalacia: strange tumours in strange places"],"prefix":"10.1093","volume":"61","author":[{"given":"D","family":"Weiss","sequence":"first","affiliation":[{"name":"Veterans Administration Medical Center, Department of Internal Medicine , Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R S","family":"Bar","sequence":"additional","affiliation":[{"name":"Veterans Administration Medical Center, Department of Internal Medicine , Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Weidner","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa , Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Wener","sequence":"additional","affiliation":[{"name":"Veterans Administration Medical Center, Department of Internal Medicine , Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Lee","sequence":"additional","affiliation":[{"name":"Veterans Administration Medical Center, Department of Internal Medicine , Iowa City, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1985,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/ki.1983.133","article-title":"Oncogenic hypophosphatemic osteomalacia","volume":"24","author":"AGUS, Z.S.","year":"1983","unstructured":"AGUS, Z.S. (1983a). Oncogenic hypophosphatemic osteomalacia. Kidney International, 24, 113.","journal-title":"Kidney International"},{"key":"ref_2","first-page":"3","article-title":"Renal handling of phosphate. In Textbook ofNephrology","author":"AGUS, Z.S.","year":"1983","unstructured":"AGUS, Z.S. (1983b). Renal handling of phosphate. In Textbook ofNephrology S.G. Massry & R.J. Glassock, (eds) 3, p. 89, Williams and Wilkins: Baltimore, Maryland."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0022-3476(77)80444-7","article-title":"Vitamin D-resistant rickets associated with epidermal nevus syndrome: Demonstration of a phosphaturic substance in the dermal lesions","volume":"91","author":"ROSENTHAL, I.M.","year":"1977","unstructured":"ROSENTHAL, I.M. (1977). Vitamin D-resistant rickets associated with epidermal nevus syndrome: Demonstration of a phosphaturic substance in the dermal lesions. Journal of Pediatrics, 91, 56.","journal-title":"Journal of Pediatrics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1016\/S0021-9258(17)33513-5","article-title":"Stimulation of 25hydroxyvitamin D3-la-hydroxylase by phosphate depletion","volume":"251","author":"BAXTER, L.A.; DELUCA, H.F.","year":"1976","unstructured":"BAXTER, L.A. & DELUCA, H.F. (1976). Stimulation of 25hydroxyvitamin D3-la-hydroxylase by phosphate depletion. Journal of Biological Chemistry, 251, 3158.","journal-title":"Journal of Biological Chemistry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1210\/jcem-46-2-284","article-title":"Vitamin D metabolites and bone mineralization in man","volume":"46","author":"BORDIER, P.; RASMUSSEN, H.; MARIE, P.; MIRAVET, L.; GUERIS, J.; RYCKWAERT, A.","year":"1978","unstructured":"BORDIER, P., RASMUSSEN, H., MARIE, P., MIRAVET, L., GUERIS, J. & RYCKWAERT, A. (1978). Vitamin D metabolites and bone mineralization in man. 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Journal of Clinical Investigation, 60, 1046.","journal-title":"Vitamin D, Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism. Proceedings of the Fifth Workshop on Vitamin; Journal of Clinical Investigation; Osteomalacia due to la-25-Dihydroxycholecalciferol deficiency. Association with a giant cell tumor of bone"},{"key":"ref_7","article-title":"Distinctive tumors of bone and soft tissue causing acquired vitamin-D resistant osteomalacia","volume":"353","author":"EVANS, D.J.; AZZOPARDI, J.G.","year":"1972","unstructured":"EVANS, D.J. & AZZOPARDI, J.G. (1972). Distinctive tumors of bone and soft tissue causing acquired vitamin-D resistant osteomalacia. Lancet, i, 353.","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1210\/jcem-49-6-873","article-title":"Tumor-induced vitamin D-resistant hypophosphatemic osteomalacia associated with proximal renal tubular dysfunction and 1,25 dihydroxyvitamin D deficiency","volume":"49","author":"FUKUMOTO, Y.; TARUI, S.; TSUKIYAMA, K.; ICHIHARA, K.; MORIWAKI, K.; NONAKA, K.; MIZUSHIMA, T.; KOBAYA-SHI, Y.; DOKOH, S.; FUKUNAGA, M.; MORITA, R.","year":"1979","unstructured":"FUKUMOTO, Y., TARUI, S., TSUKIYAMA, K., ICHIHARA, K., MORIWAKI, K., NONAKA, K., MIZUSHIMA, T., KOBAYA-SHI, Y., DOKOH, S., FUKUNAGA, M. & MORITA, R. (1979). Tumor-induced vitamin D-resistant hypophosphatemic osteomalacia associated with proximal renal tubular dysfunction and 1,25 dihydroxyvitamin D deficiency. Journal of Clinical Endocrinology and Metabolism, 49, 873.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1073\/pnas.78.2.1199","article-title":"Localization of 25-hydroxyvitamin D3-la-hydroxylase and 24-hydroxylase along the rat nephron","volume":"78","author":"KAWASHIMA, H.; TORIKAI, S.; KUROKAWA, K.","year":"1981","unstructured":"KAWASHIMA, H., TORIKAI, S. & KUROKAWA, K. (1981). Localization of 25-hydroxyvitamin D3-la-hydroxylase and 24-hydroxylase along the rat nephron. Proceedings of the National Academy of Sciences, 78, 1199.","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref_10","first-page":"\"421A\" # \"295.\"","article-title":"Evidence for a humoral phosphaturic factor in oncogenic hypophosphatemic osteomalacia","volume":"27","author":"LAU, K.; STOM, M.C.; GOLDBERG, M.; GOLDFARB, S.; GRAY, R.; LEMANN, J.; AGUS, Z.S.","year":"1979","unstructured":"LAU, K., STOM, M.C., GOLDBERG, M., GOLDFARB, S., GRAY, R., LEMANN, J. & AGUS, Z.S. (1979). Evidence for a humoral phosphaturic factor in oncogenic hypophosphatemic osteomalacia. Clinical Research, 27, 421A (abstract). LEVINE, B.S., BRAUTBAR, N. & COBURN, J.W. (1978). Does vitamin D affect the renal handling of calcium and phosphorus? Mineral and Electrolyte Metabolism, 1, 295.","journal-title":"Clinical Research; Does vitamin D affect the renal handling of calcium and phosphorus"},{"key":"ref_11","first-page":"33","article-title":"Tumor-induced osteomalacia and rickets. A surgically curable syndrome","volume":"58","author":"LINOVITZ, R.J.; RESNICK, D.; KEISSLING, P.; KONDON, J.J.; SEHLER, B.; NEJDL, R.J.; ROWE, J.H.; DEFTOS, L.J.","year":"1976","unstructured":"LINOVITZ, R.J., RESNICK, D., KEISSLING, P., KONDON, J.J., SEHLER, B., NEJDL, R.J., ROWE, J.H. & DEFTOS, L.J. (1976). Tumor-induced osteomalacia and rickets. A surgically curable syndrome. Journal of Bone and Joint Surgery, 58A, 419. McCANCE, R.A. (1947). Osteomalacia with Looser's nodes (Milkman's Syndrome) due to raised resistance to vitamin D acquired about the age of 15 years. Quarterly Journal of Medicine, 16, 33.","journal-title":"Journal of Bone and Joint Surgery; Osteomalacia with Looser's nodes (Milkman's Syndrome) due to raised resistance to vitamin D acquired about the age of 15 years"},{"key":"ref_12","first-page":"418","article-title":"Tumor-induced hypophosphatemic osteomalacia. 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