{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:07:34Z","timestamp":1757700454515},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"715","license":[{"start":{"date-parts":[[1985,5,1]],"date-time":"1985-05-01T00:00:00Z","timestamp":483753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A patient who presented with acute renal failure due to renal cortical necrosis is described. Renal biopsy showed cortical infarction and angiography demonstrated aneurysms in the renal, splenic and hepatic circulations. Concurrently he was found to have an IgA kappa paraprotein with bone marrow changes diagnostic of multiple myeloma. He was treated with haemodialysis, immunosuppressive drugs and plasma exchange but died 3 months after presentation.<\/jats:p>","DOI":"10.1136\/pgmj.61.715.445","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"445-448","source":"Crossref","is-referenced-by-count":10,"title":["Acute renal failure with polyarteritis nodosa and multiple myeloma"],"prefix":"10.1093","volume":"61","author":[{"given":"A J","family":"Williams","sequence":"first","affiliation":[{"name":"The Department of Nephrology, The London Hospital , Whitechapel, London, E.1., UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A C","family":"Newland","sequence":"additional","affiliation":[{"name":"The Department of Haematology, The London Hospital , Whitechapel, London, E.1., UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F P","family":"Marsh","sequence":"additional","affiliation":[{"name":"The Department of Nephrology, The London Hospital , Whitechapel, London, E.1., UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1985,5,1]]},"reference":[{"key":"ref_1","first-page":"324","article-title":"Benign monoclonal gammaglobulinaemia and glomerulonephritis","volume":"62","author":"AVASHTI, P.S.; ERICKSON, D.G.; WILLIAMS, R.C.; TUNG, K.S.K.","year":"1977","unstructured":"AVASHTI, P.S., ERICKSON, D.G., WILLIAMS, R.C. & TUNG, K.S.K. (1977). Benign monoclonal gammaglobulinaemia and glomerulonephritis. American Journal ofMedicine, 62, 324.","journal-title":"American Journal ofMedicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000181210","article-title":"Pathogenesis of renal disease in monoclonal gammopathies: current concepts","volume":"20","author":"BEAUFILS, M.; MOREL-MAROGER, L.","year":"1978","unstructured":"BEAUFILS, M. & MOREL-MAROGER, L. (1978). Pathogenesis of renal disease in monoclonal gammopathies: current concepts. Nephron, 20, 125.","journal-title":"Nephron"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/00007611-196706000-00001","article-title":"Vasculitis with or without panniculitis in leukaemia, lymphoma and multiple myeloma","volume":"60","author":"CHRISTIANSON, H.B.; FINE, R.M.","year":"1967","unstructured":"CHRISTIANSON, H.B. & FINE, R.M. (1967). Vasculitis with or without panniculitis in leukaemia, lymphoma and multiple myeloma. Southern Medical Journal, 60, 567.","journal-title":"Southern Medical Journal"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1159\/000180902","article-title":"Proliferative glomerulonephritis in monoclonal gammopathy","volume":"19","author":"DHAR, S.K.; SMITH, E.C.; FRESCO, R.","year":"1977","unstructured":"DHAR, S.K., SMITH, E.C. & FRESCO, R. (1977). Proliferative glomerulonephritis in monoclonal gammopathy. Nephron, 19, 288.","journal-title":"Nephron"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/ard.40.4.419","article-title":"Polyarteritis nodosa associated with acute cytomegalovirus infection","volume":"40","author":"DOHERTY, M.; BRADFIELD, J.W.","year":"1981","unstructured":"DOHERTY, M. & BRADFIELD, J.W. (1981). Polyarteritis nodosa associated with acute cytomegalovirus infection. 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Hairy cell leukaemia with polyarteritis nodosa. Lancet, ii, 280.","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0091-6749(80)90020-2","article-title":"The role of cryoglobulins and immune complexes in vasculitis","volume":"66","author":"FRANKLIN, E.C.","year":"1980","unstructured":"FRANKLIN, E.C. (1980). The role of cryoglobulins and immune complexes in vasculitis. Journal of Allergy and Clinical Immunology, 66, 269.","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"ref_9","author":"GALLO, G.R.; FEINER, H.D.; KATZ, L.A.; FELDMANN, G.M.; CORREA, E.B.; CHUBA, J.V.; BUXBAUM, J.N.","year":"1980","unstructured":"GALLO, G.R., FEINER, H.D., KATZ, L.A., FELDMANN, G.M., CORREA, E.B., CHUBA, J.V. & BUXBAUM, J.N. (1980)."},{"key":"ref_10","first-page":"621","article-title":"Nodular glomerulopathy associated with non-amyloidotic kappa light chain deposits and excess immunoglobulin light chain synthesis","volume":"99","unstructured":"Nodular glomerulopathy associated with non-amyloidotic kappa light chain deposits and excess immunoglobulin light chain synthesis. American Journal of Pathology, 99, 621.","journal-title":"American Journal of Pathology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1056\/NEJM197201062860103","article-title":"Periarteritis nodosa, Australia antigen and lymphatic leukaemia","volume":"286","author":"GERBER, M.A.; BRODIN, A.; STEINBERG, D.; VERNACE, S.; YONG, C.; PARONETTO, F.","year":"1972","unstructured":"GERBER, M.A., BRODIN, A., STEINBERG, D., VERNACE, S., YONG, C. & PARONETTO, F. (1972). Periarteritis nodosa, Australia antigen and lymphatic leukaemia. New England Journal of Medicine, 286, 14.","journal-title":"New England Journal of Medicine"},{"key":"ref_12","first-page":"1149","article-title":"Association between polyarteritis and Australia antigen","volume":"ii,","author":"GOCKE, D.J.; HSU, K.; MORGAN, C.; BORMBARDIERI, S.; MOCKSHIN, M.; C, C.H.R.I.S.T.I.A.N.C.","year":"1970","unstructured":"GOCKE, D.J., HSU, K., MORGAN, C., BORMBARDIERI, S., MOCKSHIN, M. & CHRISTIAN. C.C. (1970). Association between polyarteritis and Australia antigen. Lancet, ii, 1149.","journal-title":"Lancet"},{"key":"ref_13","article-title":"Saturation of the reticuloendothelial system with soluble immune complexes","volume":"112","author":"HAAKENSTAD, A.O.; MANNIK, M.","year":"1974","unstructured":"HAAKENSTAD, A.O. & MANNIK, M. (1974). Saturation of the reticuloendothelial system with soluble immune complexes. Journal of Immunology, 112, 1939.","journal-title":"Journal of Immunology"},{"issue":"464","key":"ref_14","first-page":"1","article-title":"Discrete gammaglobulin (M-) components in serum. (Clinical study of 150 subjects without myelomatosis)","volume":"181","author":"HALLEN, J.","year":"1966","unstructured":"HALLEN, J. (1966). Discrete gammaglobulin (M-) components in serum. (Clinical study of 150 subjects without myelomatosis). Acta Medica Scandinavica, 181, (Suppl 464), 1.","journal-title":"Acta Medica Scandinavica"},{"key":"ref_15","first-page":"247","article-title":"Facultative IgG paraproteinaemia in polyarteritis nodosa. Sbornik vedeckych praci Lekarske fakulty uk v Hradci","volume":"17","author":"HRNCIR, Z.; MRACEK, J.; NOZICKA, Z.; TICHY, M.; VAN-ASEK, J.; VODICKOVA, L.","year":"1974","unstructured":"HRNCIR, Z., MRACEK, J., NOZICKA, Z., TICHY, M., VAN-ASEK, J. & VODICKOVA, L. (1974). Facultative IgG paraproteinaemia in polyarteritis nodosa. Sbornik vedeckych praci Lekarske fakulty uk v Hradci Kralove, 17, 247.","journal-title":"Kralove"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archinte.1970.00310040120015","article-title":"Monoclonal gammopathy, glomerulonephritis and the nephrotic syndrome","volume":"125","author":"KAPLAN, N.G.; KAPLAN, K.C.","year":"1970","unstructured":"KAPLAN, N.G. & KAPLAN, K.C. (1970). Monoclonal gammopathy, glomerulonephritis and the nephrotic syndrome. Archives of Internal Medicine, 125, 696.","journal-title":"Archives of Internal Medicine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000182980","article-title":"Multiple myeloma presenting as dense deposit disease. Light chain nephropathy","volume":"34","author":"KNOBLER, H.; KOPOLOVIC, J.; KLEINMAN, Y.; RUBINGER, D.; SILVER, J.; FRIEDLAENDER, M.M.; POPOVTZER, M.M.","year":"1983","unstructured":"KNOBLER, H., KOPOLOVIC, J., KLEINMAN, Y., RUBINGER, D., SILVER, J., FRIEDLAENDER, M.M. & POPOVTZER, M.M. (1983). Multiple myeloma presenting as dense deposit disease. Light chain nephropathy. Nephron, 34, 58.","journal-title":"Nephron"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0002-9343(69)90033-3","article-title":"Acute anuria due to polyarteritis nodosa","volume":"46","author":"LADEFOGED, J.; NIELSEN, B.; RAASCHOU, F.; SORENSON, A.W.S.","year":"1969","unstructured":"LADEFOGED, J., NIELSEN, B., RAASCHOU, F. & SORENSON, A.W.S. (1969). Acute anuria due to polyarteritis nodosa. American Journal of Medicine, 46, 827.","journal-title":"American Journal of Medicine"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0002-9343(76)90440-X","article-title":"Manifestations of systemic light chain deposition","volume":"60","author":"RANDALL, R.E.; WILLIAMSON, W.C.; MULLINAX, F.; TUNG, M.Y.; STILL, W.J.C.","year":"1976","unstructured":"RANDALL, R.E., WILLIAMSON, W.C., MULLINAX, F., TUNG, M.Y. & STILL, W.J.C. (1976). Manifestations of systemic light chain deposition. American Journal of Medicine, 60, 293.","journal-title":"American Journal of Medicine"},{"key":"ref_20","first-page":"212","article-title":"Immunopathological studies of polyarteritis nodosa and Wegener's granulomatosis: a report of 43 patients with 51 renal biopsies","volume":"206","author":"RONCO, P.; VERROUST, P.; MIGNON, F.; KOURILSKY, O.; VANHILLE, P.H.; MEYRIER, A.; MERY, Ph; MOREL-MAROGER, L.","year":"1983","unstructured":"RONCO, P., VERROUST, P., MIGNON, F., KOURILSKY, O., VANHILLE, P.H., MEYRIER, A., MERY, Ph. & MOREL-MAROGER, L. (1983). Immunopathological studies of polyarteritis nodosa and Wegener's granulomatosis: a report of 43 patients with 51 renal biopsies. Quarterly Journal of Medicine, 206, 212.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_21","first-page":"557","article-title":"Kappa light chain glomerulosclerosis in multiple myeloma","volume":"101","author":"SEYMOUR, A.E.; THOMPSON, A.J.; SMITH, P.S.; WOODROFFE, A.J.; CLARKSON, A.R.","year":"1980","unstructured":"SEYMOUR, A.E., THOMPSON, A.J., SMITH, P.S., WOODROFFE, A.J. & CLARKSON, A.R. (1980). Kappa light chain glomerulosclerosis in multiple myeloma. American Journal of Pathology, 101, 557.","journal-title":"American Journal of Pathology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/path.1711300404","article-title":"Proliferative glomerulonephropathy in multiple myeloma","volume":"130","author":"SILVA, F.G.; MEYRIER, A.; MOREL-MAROGER, L.; PIRANI, C.L.","year":"1980","unstructured":"SILVA, F.G., MEYRIER, A., MOREL-MAROGER, L. & PIRANI, C.L. (1980). Proliferative glomerulonephropathy in multiple myeloma. Journal of Pathology, 130, 229.","journal-title":"Journal of Pathology"},{"key":"ref_23","first-page":"1","article-title":"Renal disease in essential mixed cryoglobulinaemia. Longterm follow-up of 44 patients","volume":"50","author":"TARANTINO, A.; VECCHI, D.E.; A., M.O.N.T.A.G.N.I.N.O.; G., I.M.-B.A.S.C.I.A.T.I.; F., M.I.H.A.T.S.C.H.; J., M.; ZOLLINGER, H.U.; BELGIOJARO, B.A.R.B.I.A.N.O.D.I.; G., B.U.S.N.A.C.H.; G.; PONTICELLI, C.","year":"1981","unstructured":"TARANTINO, A., DE VECCHI, A., MONTAGNINO, G., IM-BASCIATI, F., MIHATSCH, M.J., ZOLLINGER, H.U., BARBIANO DI BELGIOJARO, G., BUSNACH, G. & PONTICELLI, C. (1981). Renal disease in essential mixed cryoglobulinaemia. Longterm follow-up of 44 patients. Quarterly Journal of Medicine, 50, 1.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1136\/jcp.27.11.863","article-title":"The role of circulating hepatitis B antigen antibody immune complexes in the pathogenesis of vascular and hepatic manifestations in polyarteritis nodosa","volume":"27","author":"TREPO, C.G.; ZUCKERMAN, A.J.; BIRD, R.C.; PRINCE, A.M.","year":"1974","unstructured":"TREPO, C.G., ZUCKERMAN, A.J., BIRD, R.C. & PRINCE, A.M. (1974). The role of circulating hepatitis B antigen antibody immune complexes in the pathogenesis of vascular and hepatic manifestations in polyarteritis nodosa. 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