{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:25:18Z","timestamp":1760016318141},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"717","license":[{"start":{"date-parts":[[1985,7,1]],"date-time":"1985-07-01T00:00:00Z","timestamp":489024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,7,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Serum creatine kinase (CK) activity was measured after intramuscular injections in 44 patients hospitalized for non-cardiac reasons. The drugs injected were: diazepam, dipyrone, metoclopramide, meperidine, pentazocine and procaine penicillin. Only 3 out of 44 patients (7%) demonstrated significant elevation of CK levels following the intramuscular injections. In these 3 patients the elevation was mainly due to a rise of the MM-isoenzyme fraction with MB levels increased in one patient.<\/jats:p>\n               <jats:p>These findings do not justify the common clinical notion of regarding intramuscular injections as a frequent cause of serum CK elevation. It is concluded that high CK serum values in a patient with chest pain should always be considered with utmost suspicion, disregarding the possible effects of a previous intramuscular injection.<\/jats:p>","DOI":"10.1136\/pgmj.61.717.595","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"595-598","source":"Crossref","is-referenced-by-count":9,"title":["Serum creatine kinase after intramuscular injections"],"prefix":"10.1093","volume":"61","author":[{"given":"F","family":"Konikoff","sequence":"first","affiliation":[{"name":"Department of Internal Medicine E, Beilinson Medical Center , Petah-Tiqva, Israel"},{"name":"Tel Aviv University Sackler School of Medicine , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Halevy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine E, Beilinson Medical Center , Petah-Tiqva, Israel"},{"name":"Tel Aviv University Sackler School of Medicine , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Theodor","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine E, Beilinson Medical Center , Petah-Tiqva, Israel"},{"name":"Tel Aviv University Sackler School of Medicine , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1985,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0009-8981(84)90359-0","article-title":"Comparison of serum creatine kinase and creatine kinase MB activities post marathon race versus post myocardial infarction","volume":"138","author":"APPLE, F.S.; ROGERS, M.A.; SHERMAN, W.M.; IVY, J.L.","year":"1984","unstructured":"APPLE, F.S., ROGERS, M.A., SHERMAN, W.M. & IVY, J.L. (1984). Comparison of serum creatine kinase and creatine kinase MB activities post marathon race versus post myocardial infarction. Clinica Chimica Acta, 138, 111.","journal-title":"Clinica Chimica Acta"},{"key":"ref_2","first-page":"1433","article-title":"Acute myocardial infarction. In Harrison's Principles of Internal Medicine","author":"BRAUNWALD, E.; ALPERT, J.S.","year":"1983","unstructured":"BRAUNWALD, E. & ALPERT, J.S. (1983). Acute myocardial infarction. In Harrison's Principles of Internal Medicine, Petersdorf, R.G., Adams, R.D., Braunwald, E., Isselbacher, K.J., Martin, J.B. & Wilson, J.D. (eds) 10th edition, p. 1433. McGraw Hill Inc.: New York.","edition":"10th edition"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1056\/NEJM197208102870619","article-title":"Elevated serum CPK after drug injections","volume":"287","author":"CACACE, L.","year":"1972","unstructured":"CACACE, L. (1972). Elevated serum CPK after drug injections. New England Journal of Medicine, 287, 309.","journal-title":"New England Journal of Medicine"},{"key":"ref_4","first-page":"625","article-title":"CPK test - effect of intramuscular injection in myocardial infarction","volume":"219","author":"COHEN, L.","year":"1972","unstructured":"COHEN, L. (1972). CPK test - effect of intramuscular injection in myocardial infarction. Journal ofthe American Medical Association, 219, 625.","journal-title":"Journal ofthe American Medical Association"},{"key":"ref_5","series-title":"Verlag Chemie Weinheim and Academic Press: N","first-page":"784","article-title":"Creatine kinase. In Methods ofEnzymatic","volume":"2","author":"FORSTER, G.; BERNT, E.; BERGMEYER, H.U.","year":"1974","unstructured":"FORSTER, G., BERNT, E. & BERGMEYER, H.U. (1974). Creatine kinase. In Methods ofEnzymatic Analysis, Bergmeyer, H.U. (ed.), 2nd edition, vol. 2, p. 784. Verlag Chemie Weinheim and Academic Press: N.Y. and London."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1056\/NEJM197303292881317","article-title":"Pain and CPK elevation after intramuscular digoxin","volume":"288","author":"GREENBLATT, D.J.; DUHME, D.W.; KOCH-WESER, J.","year":"1973","unstructured":"GREENBLATT, D.J., DUHME, D.W. & KOCH-WESER, J. (1973). Pain and CPK elevation after intramuscular digoxin. New England Journal of Medicine, 288, 689.","journal-title":"New England Journal of Medicine"},{"key":"ref_7","first-page":"1050","volume-title":"The Heart, Arteries and Veins","author":"HURST, J.W.","year":"1982","unstructured":"HURST, J.W. (1982). In The Heart, Arteries and Veins, p. 1050. McGraw Hill: New York."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/cvr\/7.3.412","article-title":"Serum creatine phosphokinase (CPK) isoenzymes following intramuscular injections, surgery and myocardial infarction","volume":"7","author":"KLEIN, M.S.; SHELL, W.E.; SOBEL, B.E.","year":"1973","unstructured":"KLEIN, M.S., SHELL, W.E. & SOBEL, B.E. (1973). Serum creatine phosphokinase (CPK) isoenzymes following intramuscular injections, surgery and myocardial infarction. Experimental and clinical studies. Cardiovascular Research, 7, 412.","journal-title":"Experimental and clinical studies. Cardiovascular Research"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1056\/NEJM197005072821907","article-title":"Abnormal serum transaminase levels after parenteral ampicillin and carbenicillin administration","volume":"282","author":"KNIRSCH, A.K.; GRALLA, E.J.","year":"1970","unstructured":"KNIRSCH, A.K. & GRALLA, E.J. (1970). Abnormal serum transaminase levels after parenteral ampicillin and carbenicillin administration. New England Journal of Medicine, 282, 1081.","journal-title":"New England Journal of Medicine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1001\/archinte.1981.00340020026011","article-title":"Serum creatine kinase MB isoenzyme activity in long-term hemodialysis patients","volume":"141","unstructured":"Serum creatine kinase MB isoenzyme activity in long-term hemodialysis patients. Archives of Internal Medicine, 141, 164.","journal-title":"Archives of Internal Medicine"},{"issue":"42","key":"ref_11","first-page":"1382","article-title":"Effect of intramuscular injections on serum creatine phosphokinase activity","volume":"259","author":"MELTZER, H.Y.; MROZAK, S.; BOYER, M.","year":"1970","unstructured":"MELTZER, H.Y., MROZAK, S. & BOYER, M. (1970). Effect of intramuscular injections on serum creatine phosphokinase activity. American Journal ofthe Medical Sciences, 259,42. NEVINS, M.A., SARAN, M., BRIGHT, M. & LYON, L.Y. (1973). Pitfalls in interpreting serum creatine phosphokinase activity. Journal ofthe American Medical Association, 224, 1382.","journal-title":"American Journal ofthe Medical Sciences; Pitfalls in interpreting serum creatine phosphokinase activity"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1001\/jama.1974.03230520036027","article-title":"Serum creatine phosphokinase activity after intramuscular injection. The effect ofdose, concentration and volume","volume":"229","author":"SIDELL, F.R.; CULVER, D.L.; KAMINSKIS, A.","year":"1974","unstructured":"SIDELL, F.R., CULVER, D.L. & KAMINSKIS, A. (1974). Serum creatine phosphokinase activity after intramuscular injection. The effect ofdose, concentration and volume. Journal of the American Medical Association, 229, 1894.","journal-title":"Journal of the American Medical Association"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0009-8981(68)90023-5","article-title":"A rapid method for the analysis ofcreatine phosphokinase isoenzymes","volume":"21","author":"TRAINER, T.D.; GRUENIG, D.","year":"1968","unstructured":"TRAINER, T.D. & GRUENIG, D. (1968). A rapid method for the analysis ofcreatine phosphokinase isoenzymes. Clinica Chimica Acta, 21, 151.","journal-title":"Clinica Chimica Acta"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/61\/717\/595\/50156189\/postgradmedj-61-595.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/61\/717\/595\/50156189\/postgradmedj-61-595.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T13:14:04Z","timestamp":1683206044000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/61\/717\/595\/7046943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,7,1]]},"references-count":13,"journal-issue":{"issue":"717","published-online":{"date-parts":[[1985,7,1]]},"published-print":{"date-parts":[[1985,7,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.61.717.595","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1985,7]]},"published":{"date-parts":[[1985,7,1]]}}}