{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:06:54Z","timestamp":1760249214563},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"718","license":[{"start":{"date-parts":[[1985,8,1]],"date-time":"1985-08-01T00:00:00Z","timestamp":491702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Twenty-eight patients with wide spectrum organ involvement of progressive systemic sclerosis but without signs or symptoms suggestive of cardiac involvement were studied by non-invasive cardiac techniques. The 12-lead electrocardiogram showed abnormalities in 6 patients: one had abnormal T waves and 5 had complete or incomplete right bundle branch block. Twenty-four hour ambulatory electrocardiography demonstrated higher average heart rates than in similar aged controls (82 +\/- 9 vs 74 +\/- 9 beats\/min, P less than 0.05). In one patient a short run of ventricular tachycardia was recorded. No other significant arrhythmia was documented. Echocardiographic measurements were within normal ranges but small pericardial effusions were observed in two patients (7%). Resting first pass radionuclide angiography, utilizing 12 mCi of technetium 99m were performed in 23 patients. Seven patients (30%) had abnormal wall motion (diffuse hypokinesia), with a significant decrease in ejection fraction in comparison to those with normal wall motion (44 +\/- 6% vs 60 +\/- 6% P less than 0.01). Those with abnormal wall motion had suffered the disease longer than those with normal wall motion (13 +\/- 4 vs 9.5 +\/- 7 y). In conclusion, the heart is involved in half of the patients in this series; non-invasive cardiac assessment is useful in disclosing the early cardiac involvement and may influence long-term management.<\/jats:p>","DOI":"10.1136\/pgmj.61.718.679","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"679-684","source":"Crossref","is-referenced-by-count":20,"title":["Non-invasive assessment of early cardiac involvement in systemic sclerosis"],"prefix":"10.1093","volume":"61","author":[{"given":"G S","family":"Butrous","sequence":"first","affiliation":[{"name":"Department of Cardiology, St Bartholomew's Hospital , London EC1, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P M","family":"Dowd","sequence":"additional","affiliation":[{"name":"Department of Dermatology, St Bartholomew's Hospital , London EC1, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Milne","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Bartholomew's Hospital , London EC1, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D S","family":"Dymond","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Bartholomew's Hospital , London EC1, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Caplin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Bartholomew's Hospital , London EC1, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Camm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Bartholomew's Hospital , London EC1, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1985,8,1]]},"reference":[{"key":"ref_1","first-page":"24","article-title":"Scleroderma heart disease: evidence for cold induced abnormalities of myocardial perfusion and function","volume":"64","author":"ALEXANDER, E.; HAUSER, R.; WEISS, J.L.; FIRESTEIN, G.S.; LEITL, G.; WAGNER, H.N.; STEVENS, M.B.; BECKER, L.C.","year":"1981","unstructured":"ALEXANDER, E., HAUSER, R., WEISS, J.L., FIRESTEIN, G.S., LEITL, G., WAGNER, H.N., STEVENS, M.B. & BECKER, L.C. (1981). Scleroderma heart disease: evidence for cold induced abnormalities of myocardial perfusion and function. Circulation, 64 (suppl. II), 24 (Abst.).","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.7326\/0003-4819-94-2-186","article-title":"Exercise left ventricular performance in patients with chest pain, ischemic-appearing exercise electrocardiogram, and angiographically normal coronary arteries","volume":"94","author":"ZARET, B.L.","year":"1981","unstructured":"ZARET, B.L. (1981). Exercise left ventricular performance in patients with chest pain, ischemic-appearing exercise electrocardiogram, and angiographically normal coronary arteries. Annals of Internal Medicine, 94, 186.","journal-title":"Annals of Internal Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/oxfordjournals.eurheartj.a061370","article-title":"Mean 24-hour heart rate, minimal heart rate pauses in healthy subjects 40-79 years of age","volume":"4","author":"BJERREGAARD, P.","year":"1983","unstructured":"BJERREGAARD, P. (1983). Mean 24-hour heart rate, minimal heart rate pauses in healthy subjects 40-79 years of age. European Heart Journal, 4, 44.","journal-title":"European Heart Journal"},{"issue":"913","key":"ref_4","article-title":"Primary heart disease in systemic sclerosis (scleroderma): advances in clinical and pathological features. Pathogenesis and new therapeutic approaches","volume":"102","author":"BOTSTEIN, G.R.; LEROY, E.C.","year":"1981","unstructured":"BOTSTEIN, G.R. & LEROY, E.C. (1981). Primary heart disease in systemic sclerosis (scleroderma): advances in clinical and pathological features. Pathogenesis and new therapeutic approaches. American Heart Journal, 102,913.","journal-title":"American Heart Journal"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.CIR.53.3.483","article-title":"Myocardial lesions of progressive systemic sclerosis, a cause of cardiac dysfunction","volume":"53","author":"BULKLEY, B.H.; RIDOLFI, R.L.; SALYER, W.R.; HUT-CHINS, G.M.","year":"1976","unstructured":"BULKLEY, B.H., RIDOLFI, R.L., SALYER, W.R. & HUT-CHINS, G.M. (1976). Myocardial lesions of progressive systemic sclerosis, a cause of cardiac dysfunction. Circulation, 53, 483.","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0002-8703(78)90297-1","article-title":"Angina pectoris, myocardial infarction and sudden cardiac death with normal coronary arteries: a clinicopathologic study of a patient with progressive systemic sclerosis","volume":"95","author":"BULKLEY, B.H.; KLACSMANN, P.G.; HUTCHINS, G.M.","year":"1978","unstructured":"BULKLEY, B.H., KLACSMANN, P.G. & HUTCHINS, G.M. (1978). Angina pectoris, myocardial infarction and sudden cardiac death with normal coronary arteries: a clinicopathologic study of a patient with progressive systemic sclerosis. American Heart Journal, 95, 563.","journal-title":"American Heart Journal"},{"key":"ref_7","article-title":"The rhythm of the normal heart","volume":"508","author":"CLARKE, J.M.; SHELTON, J.R.; HAMER, J.; TAYLOR, S.; VENNING, G.R.","year":"1976","unstructured":"CLARKE, J.M., SHELTON, J.R., HAMER, J., TAYLOR, S. & VENNING, G.R. (1976). The rhythm of the normal heart. Lancet, ii, 508.","journal-title":"Lancet"},{"key":"ref_8","first-page":"38","article-title":"The relationship of arrhythmias and conduction disturbances to other manifestations of cardiopulmonary disease in progressive systemic sclerosis (PSS)","volume":"71","author":"CLEMENTS, P.J.; FRUST, D.E.; CABEEN, W.; TASHKIN, D.; PAULUS, H.E.; ROBERTS, N.","year":"1981","unstructured":"CLEMENTS, P.J., FRUST, D.E., CABEEN, W., TASHKIN, D., PAULUS, H.E. & ROBERTS, N. (1981). The relationship of arrhythmias and conduction disturbances to other manifestations of cardiopulmonary disease in progressive systemic sclerosis (PSS). 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American Journal of Medicine, 46, 428.","journal-title":"American Journal of Medicine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1136\/hrt.47.1.90","article-title":"Pyrophosphate heart scan in patients with progressive systemic sclerosis","volume":"47","author":"DUSKA, F.; BRADNA, P.; NOVAK, J.; KUBICEK, J.; VIZDA, J.; KAFKA, P.; MAZUROVA, Y.; BLAHA, V.","year":"1982","unstructured":"DUSKA, F., BRADNA, P., NOVAK, J., KUBICEK, J., VIZDA, J., KAFKA, P., MAZUROVA, Y. & BLAHA, V. (1982). Pyrophosphate heart scan in patients with progressive systemic sclerosis. British Heart Journal, 47, 90.","journal-title":"British Heart Journal"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1136\/hrt.41.1.68","article-title":"Detection of post infarction left ventricular aneurysms by first pass radionuclide ventriculography using a multicrystal gamma camera","volume":"41","author":"DYMOND, D.S.; JARRITT, P.H.; BRITTON, K.E.; SPURRELL, R.A.J.","year":"1979","unstructured":"DYMOND, D.S., JARRITT, P.H., BRITTON, K.E. & SPURRELL, R.A.J. (1979). Detection of post infarction left ventricular aneurysms by first pass radionuclide ventriculography using a multicrystal gamma camera. British Heart Journal, 41, 68.","journal-title":"British Heart Journal"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1136\/hrt.43.3.270","article-title":"Dual isotope stress testing in congenital atresia ofthe left coronary ostium: applications before and after surgical treatment","volume":"43","author":"DYMOND, D.S.; CAMM, A.J.; STONE, D.L.; REES, G.M.; REES, S.; SPURRELL, R.A.J.","year":"1980","unstructured":"DYMOND, D.S., CAMM, A.J., STONE, D.L., REES, G.M., REES, S. & SPURRELL, R.A.J. (1980). Dual isotope stress testing in congenital atresia ofthe left coronary ostium: applications before and after surgical treatment. British Heart Journal, 43, 270.","journal-title":"British Heart Journal"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/0002-8703(58)90193-5","article-title":"The electrocardiogram in scleroderma. Analysis of 60 cases and review of the literature","volume":"56","author":"ESCUDERO, J.; McDEVITT, E.","year":"1958","unstructured":"ESCUDERO, J. & McDEVITT, E. (1958). The electrocardiogram in scleroderma. Analysis of 60 cases and review of the literature. American Heart Journal, 56, 846.","journal-title":"American Heart Journal"},{"key":"ref_15","article-title":"Physiological abnormalities of cardiac function in progressive systemic sclerosis with diffuse scleroderma","author":"FOLLANSBEE, W.P.; CURTISS, E.I.; MEDSGER, T.A.; STEEN, V.D.; URETSKY, B.F.; OWENS, G.R.; RODNAN, G.P.","year":"1984","unstructured":"FOLLANSBEE, W.P., CURTISS, E.I., MEDSGER, T.A., STEEN, V.D., URETSKY, B.F., OWENS, G.R. & RODNAN, G.P. (1984). Physiological abnormalities of cardiac function in progressive systemic sclerosis with diffuse scleroderma."},{"key":"ref_16","first-page":"142","article-title":"New England","volume":"310","unstructured":"New England Journal of Medicine, 310, 142.","journal-title":"Journal of Medicine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1161\/01.CIR.50.4.844","article-title":"Desubitaneis mortibus VIII; Coronary arteries and conduction system in scleroderma heart disease","volume":"50","author":"JAMES, T.N.","year":"1974","unstructured":"JAMES, T.N. (1974). Desubitaneis mortibus VIII; Coronary arteries and conduction system in scleroderma heart disease. Circulation, 50, 844.","journal-title":"Circulation"},{"key":"ref_18","first-page":"13","article-title":"Systemic scleroderma with complete heart block","volume":"72","author":"LEV, M.; LANDOWNE, M.; MATCHER, J.C.; WAGNER, J.A.","year":"1976","unstructured":"LEV, M., LANDOWNE, M., MATCHER, J.C. & WAGNER, J.A. (1976). Systemic scleroderma with complete heart block. American Heart Journal, 72, 13.","journal-title":"American Heart Journal"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1161\/01.CIR.44.1.130","article-title":"Approaches to sudden death from coronary heart disease","volume":"44","author":"LOWN, B.; WOLF, M.","year":"1971","unstructured":"LOWN, B. & WOLF, M. (1971). Approaches to sudden death from coronary heart disease. Circulation, 44, 130.","journal-title":"Circulation"},{"key":"ref_20","first-page":"321","article-title":"Clinicophathologic assessment of arrhythmias in a case of scleroderma heart disease with sudden death","volume":"12","author":"MARINATO, P.G.; THIENE, G.; MENGHETTI, L.; BUJA, G.F.; NAVA, A.; CECCHETTO, A.; ROSSI, L.","year":"1981","unstructured":"MARINATO, P.G., THIENE, G., MENGHETTI, L., BUJA, G.F., NAVA, A., CECCHETTO, A. & ROSSI, L. (1981). Clinicophathologic assessment of arrhythmias in a case of scleroderma heart disease with sudden death. European Journal of Cardiology, 12, 321. McWHORTER, J.E. & LEROY, E.C. (1974). Pericardial disease in scleroderma (systemic sclerosis). American Journal of Medicine, 57, 566.","journal-title":"European Journal of Cardiology; Pericardial disease in scleroderma (systemic sclerosis"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/clc.4960050609","article-title":"The heart in scleroderma: non invasive assessment","volume":"5","author":"MONTANES, P.; LOWLESS, C.; BLACK, C.; OAKLEY, C.M.","year":"1982","unstructured":"MONTANES, P., LOWLESS, C., BLACK, C. & OAKLEY, C.M. (1982). The heart in scleroderma: non invasive assessment. Clinical Cardiology, 5, 383.","journal-title":"Clinical Cardiology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/hrt.23.3.243","article-title":"The heart in scleroderma","volume":"23","author":"ORAM, S.; STOKES, W.","year":"1961","unstructured":"ORAM, S. & STOKES, W. (1961). The heart in scleroderma. British Heart Journal, 23, 243.","journal-title":"British Heart Journal"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1161\/01.CIR.31.6.888","article-title":"Electrocardiographic findings among the adult population of a total natural community","volume":"31","author":"OSTRANDER, L.D.; BRANDTH, R.L.; KJELSBERG, M.O.","year":"1965","unstructured":"OSTRANDER, L.D., BRANDTH, R.L. & KJELSBERG, M.O. (1965). Electrocardiographic findings among the adult population of a total natural community, Tecumsch, Michigan. Circulation, 31, 888.","journal-title":"Tecumsch, Michigan. 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