{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:27:19Z","timestamp":1759937239665},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"719","license":[{"start":{"date-parts":[[1985,9,1]],"date-time":"1985-09-01T00:00:00Z","timestamp":494380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>To determine whether microcrystalline hydroxyapatite compound (MCHC) could reduce bone loss or its consequences in patients with chronic active hepatitis (CAH) on corticosteroid therapy, a controlled trial was conducted in 36 such patients over a period of 2 years. Both skeletal symptoms (back pain) and fractures were uncommon during the trial period but both showed non-significant differences in favour of the MCHC group and biochemical investigations were suggestive of a reduction in parathyroid over-activity. Continued reduction in bone mineral content of the radius (photon absorptiometry) was halted in those receiving MCHC and iliac crest bone biopsy showed a non-significant increase in trabecular bone volume. The fall in iliac crest cortical plate thickness was significantly less (P &amp;lt; 0.025) in the MCHC group and the results overall were consistent with a beneficial effect from MCHC in corticosteroid-induced osteoporosis.<\/jats:p>","DOI":"10.1136\/pgmj.61.719.791","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"791-796","source":"Crossref","is-referenced-by-count":16,"title":["Microcrystalline hydroxyapatite compound in prevention of bone loss in corticosteroid-treated patients with chronic active hepatitis"],"prefix":"10.1093","volume":"61","author":[{"given":"A","family":"Stellon","sequence":"first","affiliation":[{"name":"Liver Unit and Dept. of Radiology, King 's College Hospital , London S.E.5, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Davies","sequence":"additional","affiliation":[{"name":"Liver Unit and Dept. of Radiology, King 's College Hospital , London S.E.5, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Webb","sequence":"additional","affiliation":[{"name":"Dept. of Histopathology, St. Thomas ' Hospital , London S.E.1, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Williams","sequence":"additional","affiliation":[{"name":"Liver Unit and Dept. of Radiology, King 's College Hospital , London S.E.5, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1985,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0030-5898(20)31375-4","article-title":"Treatment of osteoporosis with fluoride, calcium and vitamin D","volume":"12","author":"BRIANCON, D.; MEUNIER, P.J.","year":"1981","unstructured":"BRIANCON, D. & MEUNIER, P.J. (1981). Treatment of osteoporosis with fluoride, calcium and vitamin D. Orthopaedic Clinics of North America, 12, 629.","journal-title":"Orthopaedic Clinics of North America"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1177\/014107688007301106","article-title":"Calcium metabolism in bone disease: effects of treatment with microcrystalline hydroxyapatite compound and dihydrotachysterol","volume":"73","author":"DENT, C.E.; DAVIES, I.J.","year":"1980","unstructured":"DENT, C.E. & DAVIES, I.J. (1980). Calcium metabolism in bone disease: effects of treatment with microcrystalline hydroxyapatite compound and dihydrotachysterol. Journal of the Royal Society of Medicine, 73, 780.","journal-title":"Journal of the Royal Society of Medicine"},{"key":"ref_3","first-page":"67","article-title":"Treatment of osteoporotic patients. A trial of calcium supplements (Ossopan) and ashed bone","volume":"10","author":"DURANCE, R.A.; PARSONS, V.; HAMILTON, A.T.K.I.N.S.C.J.; D., E.B.; DAVIES, C.","year":"1973","unstructured":"DURANCE, R.A., PARSONS, V., ATKINS. C.J.. HAMILTON, E.B.D. & DAVIES, C. (1973). Treatment of osteoporotic patients. A trial of calcium supplements (Ossopan) and ashed bone. Clinical Trials Journal, 10, 67.","journal-title":"Clinical Trials Journal"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/ajcn\/36.3.426","article-title":"Vitamin-D, hydroxyapatite, and calcium gluconate in treatment of cortical bone thinning in post-menopausal women with primary biliary cirrhosis","volume":"36","author":"EPSTEIN, O.; KATO, Y.; DICK, R.; SHERLOCK, S.","year":"1982","unstructured":"EPSTEIN, O., KATO, Y., DICK, R. & SHERLOCK, S. (1982). Vitamin-D, hydroxyapatite, and calcium gluconate in treatment of cortical bone thinning in post-menopausal women with primary biliary cirrhosis. American Journal of Clinical Nutrition, 36, 426.","journal-title":"American Journal of Clinical Nutrition"},{"key":"ref_5","first-page":"663","article-title":"Microcrystalline hydroxyapatite in patients with Colles' fractures","volume-title":"Glostrup Hospital,","author":"GALASKO, C.S.; RUSSELL, S.; RUSHTON, S.","year":"1984","unstructured":"GALASKO, C.S., RUSSELL, S. & RUSHTON, S. (1984). Microcrystalline hydroxyapatite in patients with Colles' fractures. In Osteoporosis, Christiansen, C., Arnaud, C.D., Nordin, B.E.C., Parfitt, A.M., Peck, W.A. & Riggs, B.L. (eds). p.663. Glostrup Hospital, Denmark. Stiftsbogtrykkin: Aalborg."},{"key":"ref_6","article-title":"Cortical and trabecular osteoporosis and their relation to fractures in the elderly","volume-title":"Osteoporosis: Recent Advances in Pathogenesis and Treatment","author":"HORSMAN, A.; NORDIN, B.E.C.; AARON, J.; MARSHALL, D.H.","year":"1980","unstructured":"HORSMAN, A., NORDIN, B.E.C., AARON, J. & MARSHALL, D.H. (1980). Cortical and trabecular osteoporosis and their relation to fractures in the elderly. In Osteoporosis: Recent Advances in Pathogenesis and Treatment."},{"key":"ref_7","first-page":"175","article-title":"Glucocorticoid-induced osteoporosis. Osteoporosis: Recent Advances in Pathogenesis and Treatment","author":"De Luca, H.F.; Frost, H.M.; Jee, W.S.; Johnston, C.","year":"1981","unstructured":"De Luca, H.F., Frost, H.M., Jee, W.S., Johnston, C.C. & Parfitt, A.M. (eds). p. 175. University Park Press: Baltimore. JEE, W.S. & CLARK, I. (1981). Glucocorticoid-induced osteoporosis. Osteoporosis: Recent Advances in Pathogenesis and Treatment."},{"key":"ref_8","first-page":"331","author":"De Luca, H.F.; Frost, H.M.; Jee, W.S.Johnston; C.","unstructured":"De Luca, H.F., Frost, H.M., Jee, W.S. Johnston, C.C. & Parfitt, A.M. (eds). p 331. University Park Press: Baltimore."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0009-9260(82)80276-6","article-title":"Radiological patterns ofcortical bone modelling inwomen with chronic liver disease","volume":"33","author":"KATO, Y.; EPSTEIN, O.; DICK, R.; SHERLOCK, S.","year":"1982","unstructured":"KATO, Y., EPSTEIN, O., DICK, R. & SHERLOCK, S. (1982). Radiological patterns ofcortical bone modelling inwomen with chronic liver disease. Clinical Radiology, 33, 313.","journal-title":"Clinical Radiology"},{"key":"ref_10","first-page":"24","article-title":"Bone histomorphometry in osteoporosis. In Osteoporosis II","volume-title":"Grune and","author":"MEUNIER, P.J.; COURPRON, P.; EDOUARD, C.; ALEXAN-DRE, C.; BRESSOT, C.; LIPS, P.; BOYCE, B.F.","year":"1979","unstructured":"MEUNIER, P.J., COURPRON, P., EDOUARD, C., ALEXAN-DRE, C., BRESSOT, C., LIPS, P. & BOYCE, B.F. (1979). Bone histomorphometry in osteoporosis. In Osteoporosis II. Barzel, V.S. (ed). p. 24, Grune and Stratton: New York."},{"key":"ref_11","article-title":"Dynamic bone histomorphometry in primary osteoporosis. Osteoporosis: A Multidisciplinary Problem","author":"MEUNIER, P.J.; BRIANCON, D.; SELLAMI, S.; EDOUARD, C.; CHARAISSENX, P.; ARLOT, M.","year":"1983","unstructured":"MEUNIER, P.J., BRIANCON, D., SELLAMI, S., EDOUARD, C., CHARAISSENX, P. & ARLOT, M. (1983). Dynamic bone histomorphometry in primary osteoporosis. Osteoporosis: A Multidisciplinary Problem."},{"key":"ref_12","first-page":"67","author":"Dixon, A.St J.; Russell, R.G.G.; Stamp, T.C.B.","year":"(eds).","unstructured":"Dixon, A.St.J., Russell, R.G.G. & Stamp, T.C.B. (eds). p. 67. Academic Press: London and New York."},{"key":"ref_13","article-title":"The pathogenesis and treatment of involutional osteoporosis. In Osteoporosis: A Multidisciplinary Problem","author":"DEUXCHAISNES, N.A.G.A.N.T.D.E.; C.","year":"1983","unstructured":"NAGANT DE DEUXCHAISNES, C. (1983). The pathogenesis and treatment of involutional osteoporosis. In Osteoporosis: A Multidisciplinary Problem."},{"key":"ref_14","author":"Dixon, A.St J.; Russell, R.G.G.; Stamp, T.","unstructured":"Dixon, A.St. J., Russell, R.G.G. & Stamp, T.C.B. (eds). Academic Press, Grune and Stratton: London and New York."},{"key":"ref_15","first-page":"734","article-title":"Microcrystalline calcium hydroxyapatite compound (Ossopan) in the prevention of osteoporosis due to corticosteroid therapy","volume":"8","author":"NILSEN, K.H.; JAYSON, M.I.V.; DIXON, A.St J.","year":"1978","unstructured":"NILSEN, K.H., JAYSON, M.I.V. & DIXON, A.St.J. (1978). Microcrystalline calcium hydroxyapatite compound (Ossopan) in the prevention of osteoporosis due to corticosteroid therapy. 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(1980). Treatment of spinal osteoporosis in post-menopausal women. British Medical Journal, i, 451.","journal-title":"British Medical Journal"},{"key":"ref_19","first-page":"273","article-title":"Morphologic basis of bone mineral measurements: transient and steady state effects of treatment in osteoporosis","volume":"4","author":"PARFITT, A.M.","year":"1980","unstructured":"PARFITT, A.M. (1980). Morphologic basis of bone mineral measurements: transient and steady state effects of treatment in osteoporosis. Mineral Electrolyte Metabolism, 4, 273.","journal-title":"Mineral Electrolyte Metabolism"},{"key":"ref_20","article-title":"The physiologic and clinical significance of bone histomorphometric data. Bone Histomorphometry Techniques and Interpretation","author":"PARFITT, A.M.","year":"1982","unstructured":"PARFITT, AM. (1982). The physiologic and clinical significance of bone histomorphometric data. 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Clinical Science, 58, 287.","journal-title":"Clinical Science"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/61\/719\/791\/50155920\/postgradmedj-61-791.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/61\/719\/791\/50155920\/postgradmedj-61-791.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T13:23:10Z","timestamp":1683206590000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/61\/719\/791\/7047025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,9,1]]},"references-count":28,"journal-issue":{"issue":"719","published-online":{"date-parts":[[1985,9,1]]},"published-print":{"date-parts":[[1985,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.61.719.791","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1985,9]]},"published":{"date-parts":[[1985,9,1]]}}}