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Fixed dose combinations of a thiazide and potassium sparing diuretic did not significantly reduce the prevalence of hypokalaemia and the combination of amiloride-hydrochlorothiazide was associated with a disproportionate number of cases of hyponatraemia. The desirability of the current widespread use of fixed dose combination diuretics over less expensive single agents is questioned.<\/jats:p>","DOI":"10.1136\/pgmj.62.725.159","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"159-162","source":"Crossref","is-referenced-by-count":17,"title":["Plasma electrolytes in elderly patients taking fixed combination diuretics"],"prefix":"10.1093","volume":"62","author":[{"given":"A J","family":"Bayer","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, University Hospital of Wales , Heath Park, Cardiff CF4 4XW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Farag","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, University Hospital of Wales , Heath Park, Cardiff CF4 4XW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Browne","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, University Hospital of Wales , Heath Park, Cardiff CF4 4XW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M S J","family":"Pathy","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, University Hospital of Wales , Heath Park, Cardiff CF4 4XW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1986,3,1]]},"reference":[{"key":"ref_1","first-page":"413","article-title":"Amiloride hydrochloride combined with hydrochlorothiazide in the control of hypertension and plasma potassium levels","volume":"26","author":"ANTCLIFF, A.C.; BEEVERS, D.G.; HAMILTON, M.; HAR-PUR, J.E.","year":"1972","unstructured":"ANTCLIFF, A.C., BEEVERS, D.G., HAMILTON, M. & HAR-PUR, J.E. 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Diuretic therapy and hypokalaemia in geriatric out-patients. Danish Medical Bulletin, 25, 126.","journal-title":"Danish Medical Bulletin"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1136\/bmj.1.6009.565","article-title":"Medicines and elderly people: a general practice survey","volume":"1","author":"LAW, R.; CHALMERS, C.","year":"1976","unstructured":"LAW, R. & CHALMERS, C. (1976). Medicines and elderly people: a general practice survey. British Medical Journal, 1, 565.","journal-title":"British Medical Journal"},{"key":"ref_10","first-page":"1308","volume":"289","author":"MILLSON, D.; BORLAND, C.; MURPHY, P.; DAVISON, W.","year":"1984","unstructured":"MILLSON, D., BORLAND, C., MURPHY, P. & DAVISON, W. (1984). Hyponatraemia and Moduretic. British Medical Journal, 289, 1308.","journal-title":"Hyponatraemia and Moduretic. 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