{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T12:10:21Z","timestamp":1683202221438},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"726","license":[{"start":{"date-parts":[[1986,4,1]],"date-time":"1986-04-01T00:00:00Z","timestamp":512697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Ventricular arrhythmias are common in patients with mitral valve prolapse. Ten patients with echocardiographically confirmed mitral valve prolapse and documented ventricular arrhythmias were included in this study. The aim was to assess the value of combined alpha- and beta-blockade (labetalol) compared with beta-blockade alone (propranolol) in the management of ventricular arrhythmias in these patients. The study was performed using physiological stress, such as the Valsalva manoeuvre, isometric exercise and treadmill exercise, to initiate ventricular arrhythmias before and after intravenous propranolol or labetalol and to document arrhythmias during 24 hour electrocardiography before and after oral medication. Labetalol and propranolol decreased the heart rate and blood pressure response to these manoeuvres to a similar extent but labetalol was more effective in the control of the ventricular arrhythmias. These findings suggest that alpha adrenergic receptors may play a role in the pathogenesis of the ventricular arrhythmias in mitral valve prolapse syndrome and that labetalol offers an alternative treatment for the management of this condition.<\/jats:p>","DOI":"10.1136\/pgmj.62.726.259","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"259-263","source":"Crossref","is-referenced-by-count":3,"title":["Management of ventricular arrhythmias associated with mitral valve prolapse by combined alpha and beta blockade"],"prefix":"10.1093","volume":"62","author":[{"given":"G S","family":"Butrous","sequence":"first","affiliation":[{"name":"Department of Cardiology, St Bartholomew's Hospital , London, EC1A 7BE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M B","family":"Maltz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Bartholomew's Hospital , London, EC1A 7BE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"O'Keefe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Bartholomew's Hospital , London, EC1A 7BE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S O","family":"Banim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Bartholomew's Hospital , London, EC1A 7BE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Camm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Bartholomew's Hospital , London, EC1A 7BE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1986,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/hrt.39.6.641","article-title":"Heart rate response to Valsalva manoeuvre","volume":"39","author":"BALDWA, V.S.; EWING, D.J.","year":"1976","unstructured":"BALDWA, V.S. & EWING, D.J. (1976). Heart rate response to Valsalva manoeuvre. British Heart Journal, 39, 641.","journal-title":"British Heart Journal"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0002-8703(63)90375-2","article-title":"The significance of late systolic murmurs","volume":"66","author":"BARLOW, J.B.; POCOCK, W.A.; MARCHAND, P.; DENNY, M.","year":"1963","unstructured":"BARLOW, J.B., POCOCK, W.A., MARCHAND, P. & DENNY, M. (1963). The significance of late systolic murmurs. American Heart Journal, 66, 443.","journal-title":"American Heart Journal"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0002-8703(79)90425-3","article-title":"Mitral valve prolapse: the specific billowing mitral leaflet syndrome or an insignificant non-systolic clock","volume":"97","author":"BARLOW, J.B.; POCOCK, W.A.","year":"1979","unstructured":"BARLOW, J.B & POCOCK, W.A. (1979). Mitral valve prolapse: the specific billowing mitral leaflet syndrome or an insignificant non-systolic clock. American Heart Journal, 97, 277.","journal-title":"American Heart Journal"},{"issue":"1073","key":"ref_4","first-page":"741","article-title":"Ventricular arrhythmias in the syndrome of balloon deformity of mitral valve. Definition ofpossible high risk group","volume":"38","author":"MARQUIS, R.M.","year":"1976","unstructured":"MARQUIS, R.M. (1976). Ventricular arrhythmias in the syndrome of balloon deformity of mitral valve. Definition ofpossible high risk group. British Heart Journal, 38,1073. COBBS, B.W. & KING, S.B. (1977). Ventricular buckling: a factor in the abnormal ventriculogram and peculiar hemodynamics associated with mitral valve prolapse. 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A potential mediator of electrophysiological derangements","volume":"67","author":"CORR, P.B.; SHAYMAN, J.A.; KRAMER, J.B.; KIPNIS, R.J.","year":"1981","unstructured":"CORR, P.B., SHAYMAN, J.A., KRAMER, J.B. & KIPNIS, R.J. (1981). Increased alpha-adrenergic receptors in ischaemic cat myocardium. A potential mediator of electrophysiological derangements. Journal of Clinical Investigation, 67, 1232.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"656","DOI":"10.7326\/0003-4819-84-6-656","article-title":"Arrhythmias in the mitral valve prolapse syndrome","volume":"84","author":"DEMARIA, A.N.; AMSTERDAM, F.A.; VISMARA, L.A.; NEWMANN, A.; MASON, D.T.","year":"1976","unstructured":"DEMARIA, A.N., AMSTERDAM, F.A., VISMARA, L.A., NEWMANN, A. & MASON, D.T. (1976). Arrhythmias in the mitral valve prolapse syndrome. 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Sudden death in the mitral valve prolapse-click syndrome. American Journal ofCardiology, 37, 317.","journal-title":"American Journal ofCardiology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0002-9149(78)90623-9","article-title":"Cardiac biopsy evidence for a cardiomyopathy associated with symptomatic mitral valve prolapse","volume":"42","author":"MASON, J.W.; KOCH, F.H.; BILLINGHAM, M.E.; WINKLE, R.A.","year":"1978","unstructured":"MASON, J.W., KOCH, F.H., BILLINGHAM, M.E. & WINKLE, R.A. (1978). Cardiac biopsy evidence for a cardiomyopathy associated with symptomatic mitral valve prolapse. 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American Journal of Cardiology, 53, 135.","journal-title":"American Journal of Cardiology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/0002-8703(70)90134-1","article-title":"Postexercise arrhythmias in the billowing posterior mitral leaflet syndrome","volume":"80","author":"POCOCK, W.A.; BARLOW, J.B.","year":"1970","unstructured":"POCOCK, W.A. & BARLOW, J.B. (1970). Postexercise arrhythmias in the billowing posterior mitral leaflet syndrome. American Heart Journal, 80, 740.","journal-title":"American Heart Journal"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1365-2125.1976.tb00637.x","article-title":"Assessment of alpha and beta adrenoceptors blocking actions of labetalol","volume":"3","author":"RICHARDS, D.A.; TUCKMAN, J.; PRICHARD, B.N.C.","year":"1976","unstructured":"RICHARDS, D.A., TUCKMAN, J. & PRICHARD, B.N.C. (1976). Assessment of alpha and beta adrenoceptors blocking actions of labetalol. 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