{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:58:45Z","timestamp":1788472725333,"version":"build-2803163510"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"733","license":[{"start":{"date-parts":[[1986,11,1]],"date-time":"1986-11-01T00:00:00Z","timestamp":531187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The relationships between serum uric acid, serum glucose and diabetes have been examined in a survey of 7735 middle-aged men drawn at random from general practices in 24 British towns. There was a positive relationship between serum glucose and serum uric acid concentrations up to about 8.0 mmol\/l; at higher levels of glucose, serum uric acid decreased. Uric acid levels were significantly reduced in insulin-dependent diabetics and in those on oral hypoglycaemics and also in \u2018non-diabetics\u2019 with casual glucose levels &amp;gt; 10 mmol\/l.<\/jats:p>\n               <jats:p>Both uric acid and glucose concentrations were positively related to body mass index; only uric acid was positively related to alcohol intake. Men on antihypertensive treatment had raised levels of uric acid (significant) and glucose (non-significant). The positive relationship between serum uric acid and serum glucose could not be explained by associations with body mass index, alcohol intake, age, social class, gout or treatment for hypertension. It probably reflects the biochemical interaction between serum glucose and purine metabolism, with increased excretion of uric acid during hyperglycaemia and glycosuria.<\/jats:p>","DOI":"10.1136\/pgmj.62.733.1001","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:58:16Z","timestamp":1230584296000},"page":"1001-1006","source":"Crossref","is-referenced-by-count":129,"title":["Serum uric acid, serum glucose and diabetes: relationships in a population study"],"prefix":"10.1093","volume":"62","author":[{"given":"D G","family":"Cook","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology and General Practice, Royal Free Hospital School of Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A G","family":"Shaper","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and General Practice, Royal Free Hospital School of Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D S","family":"Thelle","sequence":"additional","affiliation":[{"name":"Institute of Community Medicine, University of Tromso , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T P","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Wolfson Research Laboratories, Queen Elizabeth Medical Centre , Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1986,11,1]]},"reference":[{"key":"ref_1","first-page":"443","article-title":"Gout and serum uric acid in diabetes mellitus","volume":"29","author":"BECKETT, A.G.; LEWIS, J.G.","year":"1960","unstructured":"BECKETT, A.G. & LEWIS, J.G. (1960). Gout and serum uric acid in diabetes mellitus. Quarterly Journal ofMedicine, 29, 443.","journal-title":"Quarterly Journal ofMedicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/978-1-4757-1433-3_55","article-title":"The effect of glucose upon reabsorptive transport of urate by the kidney","volume":"41","author":"BONER, G.; RIESELBACK, R.E.","year":"1974","unstructured":"BONER, G. & RIESELBACK, R.E. (1974). The effect of glucose upon reabsorptive transport of urate by the kidney. Advances in Experimental Medicine and Biology, 41, 781.","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/bmj.4.5578.505","article-title":"Renal glucose threshold variations with age","volume":"4","author":"BUTTERFIELD, W.J.H.; KEEN, H.; WHICHELOW, M.J.","year":"1967","unstructured":"BUTTERFIELD, W.J.H., KEEN, H. & WHICHELOW, M.J. (1967). Renal glucose threshold variations with age. British Medical Journal, 4, 505.","journal-title":"British Medical Journal"},{"key":"ref_4","first-page":"735","article-title":"Drug-induced diabetes","volume":"ii,","author":"DOLLERY, C.T.; PENTECOST, B.L.; SAMAAN, N.A.","year":"1962","unstructured":"DOLLERY, C.T., PENTECOST, B.L. & SAMAAN, N.A. (1962). Drug-induced diabetes. Lancet, ii, 735.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0021-9681(80)90040-5","article-title":"Serum uric acid: correlation with biochemical, anthropometric, clinical and behavioural parameters in 10,000 Israeli men","volume":"33","author":"NEUFELD, H.N.","year":"1980","unstructured":"NEUFELD, H.N. (1980). Serum uric acid: correlation with biochemical, anthropometric, clinical and behavioural parameters in 10,000 Israeli men. 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Lancet, ii, 240.","journal-title":"Lancet"},{"key":"ref_8","first-page":"1048","article-title":"Hyperglycemia and uric acid","volume":"5","author":"HERMAN, J.B.; KEYNAN, A.","year":"1969","unstructured":"HERMAN, J.B. & KEYNAN, A. (1969). Hyperglycemia and uric acid. Israeli Journal of Medical Sciences, 5, 1048.","journal-title":"Israeli Journal of Medical Sciences"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF01221964","article-title":"Diabetes, prediabetes and uricemia","volume":"12","author":"HERMAN, J.B.; MEDALIE, J.H.; GOLDBOURT, U.","year":"1976","unstructured":"HERMAN, J.B., MEDALIE, J.H. & GOLDBOURT, U. (1976).Diabetes, prediabetes and uricemia. Diabetologia, 12, 47.","journal-title":"Diabetologia"},{"key":"ref_10","author":"JARRETT, R.J.; KEEN, H.; CHAKRABARTI, R.","year":"1982","unstructured":"JARRETT, R.J., KEEN, H. & CHAKRABARTI, R. (1982)."},{"key":"ref_11","article-title":"hyperglycaemia and arterial disease. In Complications of Diabetes","author":"diabetes","unstructured":"diabetes, hyperglycaemia and arterial disease. In Complications of Diabetes, 2nd ed., Keen, H. & Jarrett, R.J. (eds). Arnold: London.","edition":"2nd ed"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1001\/archinte.1973.03650090077014","article-title":"Serum uric acid: its relationship to coronary heart disease risk factors and cardiovascular disease, Evans County, Georgia","volume":"132","author":"KLEIN, R.; KLEIN, B.E.; CORNONI, J.C.; MAREADY, J.; CASSEL, J.C.; TYROLER, H.A.","year":"1973","unstructured":"KLEIN, R., KLEIN, B.E., CORNONI, J.C., MAREADY, J., CASSEL, J.C. & TYROLER, H.A. (1973). Serum uric acid: its relationship to coronary heart disease risk factors and cardiovascular disease, Evans County, Georgia. Archives of Internal Medicine, 132, 401.","journal-title":"Archives of Internal Medicine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/bmj.283.6285.179","article-title":"British Regional Heart Study: cardiovascular risk factors in middle aged men in 24 towns","volume":"283","author":"SHAPER, A.G.; POCOCK, S.J.; WALKER, M.; COHEN, N.M.; WALE, C.J.; THOMSON, A.G.","year":"1981","unstructured":"SHAPER, A.G., POCOCK, S.J., WALKER, M., COHEN, N.M., WALE, C.J. & THOMSON, A.G. (1981). British Regional Heart Study: cardiovascular risk factors in middle aged men in 24 towns. British Medical Journal, 283, 179.","journal-title":"British Medical Journal"},{"key":"ref_14","first-page":"103","article-title":"Gout and diabetes","volume":"6","author":"WEISS, T.E.; SEGALOFF, A.; MOORE, C.","year":"1957","unstructured":"WEISS, T.E., SEGALOFF, A. & MOORE, C. (1957). Gout and diabetes. Metabolism, 6, 103.","journal-title":"Metabolism"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0021-9681(77)90083-2","article-title":"Epidemiology of serum uric acid among 8000 JapaneseAmerican men in Hawaii","volume":"30","author":"YANO, K.; RHOADS, G.G.; KAGAN, A.","year":"1977","unstructured":"YANO, K., RHOADS, G.G. & KAGAN, A. (1977). Epidemiology of serum uric acid among 8000 JapaneseAmerican men in Hawaii. Journal ofChronic Diseases, 30, 171.","journal-title":"Journal ofChronic Diseases"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0021-9681(72)90166-X","article-title":"Serum uric acid in 23,923 men and gout in a subsample of 4,257 men in France","volume":"25","author":"ZALOKAR, J.; LELLOUCH, J.; CLAUDE, J.R.; KUNTZ, D.","year":"1972","unstructured":"ZALOKAR, J., LELLOUCH, J., CLAUDE, J.R. & KUNTZ, D. (1972). Serum uric acid in 23,923 men and gout in a subsample of 4,257 men in France. Journal of Chronic Diseases, 25, 305.","journal-title":"Journal of Chronic Diseases"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/62\/733\/1001\/50157377\/postgradmedj-62-1001.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/62\/733\/1001\/50157377\/postgradmedj-62-1001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T10:58:56Z","timestamp":1683197936000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/62\/733\/1001\/7042710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,11,1]]},"references-count":16,"journal-issue":{"issue":"733","published-online":{"date-parts":[[1986,11,1]]},"published-print":{"date-parts":[[1986,11,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.62.733.1001","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1986,11]]},"published":{"date-parts":[[1986,11,1]]}}}