{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:10:40Z","timestamp":1790665840210,"version":"4.1.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"737","license":[{"start":{"date-parts":[[1987,3,1]],"date-time":"1987-03-01T00:00:00Z","timestamp":541555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,3,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Oral administration of 1 g of acetazolamide to 8 normal subjects studied at sea level and in normoxia caused an acute increase in cerebral blood flow (CBF). During the subsequent prolonged oral treatment with 1 g of acetazolamide daily, CBF returned to normal within 2 days. The alveolar CO2 tension decreased gradually to 70% of the control value, indicating hyperventilation. At sea level hyperventilation will not increase brain oxygenation significantly in normal man, as the arterial oxygen content only increases minimally, while CBF is unchanged. At high altitude the beneficial effects of acetazolamide on the symptoms of acute mountain sickness may well be due to an improved oxygen supply to the brain, as hyperventilation will, at the low ambient PO2, cause a significant increase of the arterial oxygen content, while CBF presumably is unaffected by the drug. During hypoxia at high altitude the overall effect of prolonged acetazolamide treatment may thus be equivalent to a descent by several hundred metres.<\/jats:p>","DOI":"10.1136\/pgmj.63.737.185","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"185-187","source":"Crossref","is-referenced-by-count":32,"title":["Effects of acetazolamide on cerebral blood flow and brain tissue oxygenation"],"prefix":"10.1093","volume":"63","author":[{"given":"N A","family":"Lassen","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology\/Nuclear Medicine, Bispebjerg Hospital , DK-2400 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Friberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology\/Nuclear Medicine, Bispebjerg Hospital , DK-2400 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kastrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology\/Nuclear Medicine, Bispebjerg Hospital , DK-2400 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology\/Nuclear Medicine, Bispebjerg Hospital , DK-2400 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J J","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology\/Nuclear Medicine, Bispebjerg Hospital , DK-2400 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1987,3,1]]},"reference":[{"issue":"21","key":"ref_1","first-page":"1195","article-title":"Low doses of acetazolamide to aid accommodation of men to altitude","volume":"1966","author":"Cain, S.M.; Dunn, J.E.","unstructured":"Cain, S.M. & Dunn, J.E. Low doses of acetazolamide to aid accommodation of men to altitude. J Appl Physiol 1966, 21: 1195-1200.","journal-title":"J Appl Physiol"},{"issue":"119","key":"ref_2","first-page":"331","article-title":"Effect of carbonic acid inhibition on blood gas and acid base balance during hypoxia. Bulletin Johns Hopkins'","volume":"1966","author":"Mani, K.V.; Weinstein, S.A.","unstructured":"Mani, K.V. & Weinstein, S.A. Effect of carbonic acid inhibition on blood gas and acid base balance during hypoxia. Bulletin Johns Hopkins' Hospital 1966, 119: 331-342.","journal-title":"Hospital"},{"key":"ref_3","first-page":"512516","article-title":"Amelioration of the symptoms of acute mountain sickness by staging and acetazolamide","volume":"47","author":"Evans, W.O.; Robinson, S.M.; Horstman, D.H.; Jackson, R.E.; Weiskopf, R.B.","year":"1976","unstructured":"Evans, W.O., Robinson, S.M., Horstman, D.H., Jackson, R.E. & Weiskopf, R.B. 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