{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T07:10:11Z","timestamp":1684825811412},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"737","license":[{"start":{"date-parts":[[1987,3,1]],"date-time":"1987-03-01T00:00:00Z","timestamp":541555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,3,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Very few cases of acquired severe copper deficiency have been described. The principal effects are haematological, but the precise abnormalities are uncertain due to the possible association of other deficiencies. A case of isolated severe copper deficiency associated with late onset hypogammaglobulinaemia is reported in which the chief findings were macrocytic anaemia, neutropenia and a decrease in mean platelet volume. All these abnormalities resolved when copper therapy was instituted and recurred when the medication was stopped.<\/jats:p>","DOI":"10.1136\/pgmj.63.737.205","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"205-207","source":"Crossref","is-referenced-by-count":2,"title":["Macrocytic anaemia due to copper deficiency in a patient with late onset hypogammaglobulinaemia"],"prefix":"10.1093","volume":"63","author":[{"given":"S M","family":"Oppenheimer","sequence":"first","affiliation":[{"name":"Departments of Medicine Haematology, Whittington Hospital , Highgate Hill, London, NJ95NF , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B I","family":"Hoffbrand","sequence":"additional","affiliation":[{"name":"Departments of Medicine Haematology, Whittington Hospital , Highgate Hill, London, NJ95NF , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T L","family":"Dormandy","sequence":"additional","affiliation":[{"name":"Departments of Clinical Chemistry, Haematology, Whittington Hospital , Highgate Hill, London, NJ95NF , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Parker","sequence":"additional","affiliation":[{"name":"Departments of Haematology, Whittington Hospital , , UK"},{"name":"Highgate Hill, London, NJ95NF , , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D G","family":"Wickens","sequence":"additional","affiliation":[{"name":"Departments of Clinical Chemistry, Haematology, Whittington Hospital , Highgate Hill, London, NJ95NF , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1987,3,1]]},"reference":[{"key":"ref_1","first-page":"118","article-title":"Copper deficiency in humans","volume":"20","author":"Williams, D.M.","year":"1983","unstructured":"Williams, D.M. Copper deficiency in humans. Semin Hematol 1983, 20: 118-128.","journal-title":"Semin Hematol"},{"issue":"15","key":"ref_2","first-page":"94110","article-title":"The question of copper deficiency in man","volume":"1964","author":"Cartwright, G.E.; Wintrobe, M.M.","unstructured":"Cartwright, G.E. & Wintrobe, M.M. The question of copper deficiency in man. Am J Clin Nutr 1964, 15: 94110.","journal-title":"Am J Clin Nutr"},{"issue":"34","key":"ref_3","first-page":"324","article-title":"Copper deficiency in infancy","volume":"1964","author":"Cordano, A.; Baertl, J.M.; Graham, G.G.","unstructured":"Cordano, A., Baertl, J.M. & Graham, G.G. Copper deficiency in infancy. 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N Engl J Med 1974, 291: 188 -191.","journal-title":"N Engl J Med"},{"issue":"177 185","key":"ref_8","article-title":"Observations on the anemia and neutropenia of human copper deficiency","volume":"3","author":"Zidar, B.L.; Shadduck, R.K.; Ziegler, Z.; Winkelstein, A.","year":"1977","unstructured":"Zidar, B.L., Shadduck, R.K., Ziegler, Z. & Winkelstein, A. Observations on the anemia and neutropenia of human copper deficiency. Am J Haematol 1977, 3: 177 185.","journal-title":"Am J Haematol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"470","DOI":"10.7326\/0003-4819-80-4-470","article-title":"Anemia and neutropenia caused by copper deficiency","volume":"80","author":"Dunlop, W.M.; James, G.W.; Hume, D.M.","year":"1974","unstructured":"Dunlop, W.M., James, G.W. & Hume, D.M. Anemia and neutropenia caused by copper deficiency. 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