{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T02:04:30Z","timestamp":1694311470777},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"738","license":[{"start":{"date-parts":[[1987,4,1]],"date-time":"1987-04-01T00:00:00Z","timestamp":544233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Familial dysalbuminaemic hyperthyroxinaemia (FDH) can be confused with thyrotoxicosis if clinical signs and laboratory tests are misinterpreted. We describe three members of the same family with FDH who were erroneously treated for thyrotoxicosis. Screening of other family members resulted in the discovery of a further six patients at risk of being misdiagnosed as thyrotoxic. Clinical and biochemical findings relevant to the diagnosis of FDH are discussed.<\/jats:p>","DOI":"10.1136\/pgmj.63.738.273","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"273-275","source":"Crossref","is-referenced-by-count":5,"title":["Familial dysalbuminaemic hyperthyroxinaemia"],"prefix":"10.1093","volume":"63","author":[{"given":"S J","family":"Fleming","sequence":"first","affiliation":[{"name":"Withington Hospital , Manchester, M20 8LR , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G F","family":"Applegate","sequence":"additional","affiliation":[{"name":"Withington Hospital , Manchester, M20 8LR , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C G","family":"Beardwell","sequence":"additional","affiliation":[{"name":"Withington Hospital , Manchester, M20 8LR , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1987,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1056\/NEJM198203183061103","article-title":"Familial dysalbuminemic hyperthroxinemia: a syndrome that can be confused with thyrotoxicosis","volume":"306","author":"Ruiz, M.; Rajatanavin, R.; Young, R.A.","year":"1982","unstructured":"Ruiz, M., Rajatanavin, R., Young, R.A. et al. Familial dysalbuminemic hyperthroxinemia: a syndrome that can be confused with thyrotoxicosis. N Engl J Med 1982, 306: 635-639.","journal-title":"N Engl J Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1210\/jcem-49-2-292","article-title":"Inherited abnormal thyroid hormonebinding protein causing selective increase of total serum thyroxine","volume":"49","author":"Lee, W.N.P.; Golden, M.P.van Herle; J., A.; Lippe, B.M.; Kaplan, S.A.","year":"1979","unstructured":"Lee, W.N.P., Golden, M.P. van Herle, A.J., Lippe, B.M. & Kaplan, S.A. Inherited abnormal thyroid hormonebinding protein causing selective increase of total serum thyroxine. J Clin Endocrinol Metab 1979, 49: 292-299.","journal-title":"J Clin Endocrinol Metab"},{"issue":"23","key":"ref_3","first-page":"59","article-title":"Thyroid function tests in patients with familial dysalbuminaemic hyperthyroxinaemia (FDH)","volume":"1986","author":"Stewart, M.F.; Ratcliffe, W.A.; Roberts, I.","unstructured":"Stewart, M.F., Ratcliffe, W.A. & Roberts, I. Thyroid function tests in patients with familial dysalbuminaemic hyperthyroxinaemia (FDH). Ann Clin Biochem 1986, 23: 59-64.","journal-title":"Ann Clin Biochem"},{"issue":"22","key":"ref_4","first-page":"521","article-title":"A new and distinctive albumin variant with increased affinities for both triiodothyronines and causing hyperthyroxinaemia","volume":"1985","author":"Lalloz, M.R.A.; Byfield, P.G.H.; Himsworth, R.L.","unstructured":"Lalloz,M.R.A., Byfield,P.G.H. & Himsworth, R.L. A new and distinctive albumin variant with increased affinities for both triiodothyronines and causing hyperthyroxinaemia. Clin Endocrinol 1985, 22: 521-529.","journal-title":"Clin Endocrinol"},{"issue":"53","key":"ref_5","first-page":"353","article-title":"Familial euthyroid thyroxine excess: an appropriate response to abnormal thyroxine binding associated with albumin","volume":"1981","author":"Stockigt, J.R.; Topliss, D.J.; Barlow, J.W.; White, E.L.; Hurley, D.M.; Taft, P.","unstructured":"Stockigt, J.R., Topliss, D.J., Barlow, J.W., White, E.L., Hurley, D.M., Taft, P. Familial euthyroid thyroxine excess: an appropriate response to abnormal thyroxine binding associated with albumin. J Clin Endocrinol Metab 1981, 53: 353-359.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_6","first-page":"53","article-title":"A Diagnosis of hyperthyroidism when serum thyroxine alone is raised","volume":"ii:","author":"Birkhauser, M.; Thurer, Th; Bussett, R.; Burger, A.","year":"1977","unstructured":"Birkhauser, M., Thurer, Th., Bussett, R. & Burger, A. A Diagnosis of hyperthyroidism when serum thyroxine alone is raised. Lancet 1977, ii: 53-56.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF03348351","volume":"6","author":"Rajatanavin, R.; Braverman, L.E.Euthyroid hyperthyroxinaemia","year":"1983","unstructured":"Rajatanavin, R. & Braverman, L.E. Euthyroid hyperthyroxinaemia. J Endocrinol Invest 1983, 6: 493-505.","journal-title":"J Endocrinol Invest"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2265.1983.tb03181.x","article-title":"Hyperthyroxinaemia: abnormal binding of T4 by an inherited albumin variant","volume":"18","author":"Lalloz, M.R.A.; Byfield, P.G.H.; Himsworth, R.L.","year":"1983","unstructured":"Lalloz, M.R.A., Byfield, P.G.H., Himsworth, R.L. Hyperthyroxinaemia: abnormal binding of T4 by an inherited albumin variant. Clin Endocrinol 1983, 18: 11-24.","journal-title":"Clin Endocrinol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/63\/738\/273\/50079821\/postgradmedj-63-273.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/63\/738\/273\/50079821\/postgradmedj-63-273.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T05:46:01Z","timestamp":1683265561000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/63\/738\/273\/7047320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4,1]]},"references-count":8,"journal-issue":{"issue":"738","published-online":{"date-parts":[[1987,4,1]]},"published-print":{"date-parts":[[1987,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.63.738.273","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1987,4]]},"published":{"date-parts":[[1987,4,1]]}}}