{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:59:01Z","timestamp":1768013941247,"version":"3.49.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"742","license":[{"start":{"date-parts":[[1987,8,1]],"date-time":"1987-08-01T00:00:00Z","timestamp":554774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Hypothyroid myopathy has so far been reported in long standing cases of hypothyroidism. We describe two adult patients with myopathy associated with acute transient hypothyroidism. Both presented with severe muscle aches and cramps, stiffness and spasms. Muscle enzymes were markedly elevated and electromyography in one patient showed myopathic features. Histological changes were absent in muscle biopsy, probably because of the short duration of metabolic disturbance. The myopathy subsided promptly when the hypothyroid state was reversed.<\/jats:p>","DOI":"10.1136\/pgmj.63.742.661","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"661-663","source":"Crossref","is-referenced-by-count":21,"title":["Myopathy in acute hypothyroidism"],"prefix":"10.1093","volume":"63","author":[{"given":"A W C","family":"Kung","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Hong Kong, Queen Mary Hospital , Pokfulam Road , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J T C","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Hong Kong, Queen Mary Hospital , Pokfulam Road , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y L","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Hong Kong, Queen Mary Hospital , Pokfulam Road , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C C L","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Hong Kong, Queen Mary Hospital , Pokfulam Road , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E K W","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Hong Kong, Queen Mary Hospital , Pokfulam Road , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K S L","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Hong Kong, Queen Mary Hospital , Pokfulam Road , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Y","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Hong Kong, Queen Mary Hospital , Pokfulam Road , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R T T","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Hong Kong, Queen Mary Hospital , Pokfulam Road , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1987,8,1]]},"reference":[{"issue":"26","key":"ref_1","first-page":"556","article-title":"Zur Verhutung des Cretinismus und cretinoider Zustande nach neuen Forschungen","volume":"1892","author":"Kocher, T.","unstructured":"Kocher, T., Zur Verhutung des Cretinismus und cretinoider Zustande nach neuen Forschungen. Dtsch Z Chir 1892, 26: 556-626.","journal-title":"Dtsch Z Chir"},{"issue":"50","key":"ref_2","first-page":"1351","article-title":"Syndrome of diffuse muscular hypertrophy in infants causing athletic appearance","volume":"1935","author":"Debre, R.; Semelaigne, G.","unstructured":"Debre, R. & Semelaigne, G. Syndrome of diffuse muscular hypertrophy in infants causing athletic appearance. Am J Dis Child 1935, 50: 1351-1361.","journal-title":"Am J Dis Child"},{"issue":"9","key":"ref_3","first-page":"278","article-title":"Weitere Beitrag zur Lehre von der Tetanie","volume":"1897","author":"Hoffman, J.","unstructured":"Hoffman, J. Weitere Beitrag zur Lehre von der Tetanie. Dtsch Z Nevenheilkunde (Berlin) 1897, 9: 278-290.","journal-title":"Dtsch Z Nevenheilkunde (Berlin)"},{"issue":"41","key":"ref_4","first-page":"299","article-title":"Electromyographic finding in adults with myxoedema. 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Pediatr"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/jcp.28.8.659","article-title":"Muscle fibre type changes in hypothyroid myopathy","volume":"28","author":"McKeran, R.O.; Slavin, G.; Andrews, T.M.; Ward, P.; Mair, W.G.P.","year":"1975","unstructured":"McKeran, R.O., Slavin, G., Andrews, T.M., Ward, P. & Mair, W.G.P. Muscle fibre type changes in hypothyroid myopathy. J Clin Pathol 1975, 28: 659-63.","journal-title":"J Clin Pathol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1136\/jcp.36.5.519","article-title":"Muscle morphology and metabolism in hypothyroid myopathy: effects of treatment","volume":"36","author":"Khaleeli, A.A.; Gohil, K.; PcPhail, G.Round; M., J.; Edwards, R.H.T.","year":"1983","unstructured":"Khaleeli, A.A., Gohil, K. & PcPhail, G. Round, J.M. & Edwards, R.H.T. Muscle morphology and metabolism in hypothyroid myopathy: effects of treatment. 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