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The oligoclonal bands are non-specific, and are seen in most diseases of the nervous system, but their temporal uniformity in each patient with multiple sclerosis is characteristic. Prognostically, patients with a single episode of optic neuritis or paraesthesia who have oligoclonal bands are more likely to develop multiple sclerosis than if the spinal fluid were normal. In the Guillain-Barr\u00e9 syndrome, the spinal fluid total protein is transiently elevated, with no pleocytosis. Oligoclonal bands are usually found in the acute phase and only persist in those patients with chronic or relapsing polyneuropathy.<\/jats:p>","DOI":"10.1136\/pgmj.63.743.735","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"735-740","source":"Crossref","is-referenced-by-count":6,"title":["The clinical use of cerebrospinal fluid studies in demyelinating neurological diseases"],"prefix":"10.1093","volume":"63","author":[{"given":"M G","family":"Harrington","sequence":"first","affiliation":[{"name":"Biochemical Genetics Section, Clinical Neurogenetics Branch, National Institute of Mental Health , Bethesda MD 20892 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P G","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Neurological Sciences , Glasgow G51 4TF , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1987,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1212\/WNL.30.7_Part_2.61","article-title":"Epidemiological contributions to multiple sclerosis: An overview","author":"Kurtzke, J.F.","year":"1980","unstructured":"Kurtzke, J.F. 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