{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:33:12Z","timestamp":1760016792350},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"743","license":[{"start":{"date-parts":[[1987,9,1]],"date-time":"1987-09-01T00:00:00Z","timestamp":557452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,9,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Intracranial haemorrhage (ICH), a rare complication of idiopathic thrombocytopenic purpura (ITP), described only once previously in an adult, is usually fatal. We report a previously healthy 26 year old woman with chronic ITP in whom spontaneous ICH developed. The eventual favourable outcome in this case despite severe initial neurological deficit makes this case unusual. The importance of aggressive management in an ITP associated ICH is stressed and a plan for management is suggested.<\/jats:p>","DOI":"10.1136\/pgmj.63.743.781","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"781-783","source":"Crossref","is-referenced-by-count":6,"title":["Intracranial haemorrhage in a 26 year-old woman with idiopathic thrombocytopenic purpura"],"prefix":"10.1093","volume":"63","author":[{"given":"G","family":"Awerbuch","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Arizona Health Sciences Center , Tucson, AZ. 85724 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Sandyk","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Arizona Health Sciences Center , Tucson, AZ. 85724 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1987,9,1]]},"reference":[{"issue":"29","key":"ref_1","first-page":"502","article-title":"Prognosis in idiopathic thrombocytopenic purpura of childhood","volume":"1954","author":"Komrower, G.M.; Watson, G.H.","unstructured":"Komrower, G.M. & Watson, G.H. Prognosis in idiopathic thrombocytopenic purpura of childhood. Arch Dis Child 1954, 29: 502-506.","journal-title":"Arch Dis Child"},{"issue":"67","key":"ref_2","first-page":"453460","article-title":"Intracranial haemorrhage in children with idiopathic thrombocytopenic purpura","volume":"1981","author":"Woerner, S.J.; Abildguard, C.F.; French, B.N.","unstructured":"Woerner, S.J., Abildguard, C.F. & French, B.N. Intracranial haemorrhage in children with idiopathic thrombocytopenic purpura. Pediatrics 1981, 67: 453460.","journal-title":"Pediatrics"},{"issue":"68","key":"ref_3","first-page":"971","article-title":"Idiopathic thrombocytopenic purpura in childhood","volume":"1966","author":"Lusher, J.M.; Zuelzer, W.W.","unstructured":"Lusher, J.M. & Zuelzer, W.W. Idiopathic thrombocytopenic purpura in childhood. J Pediatr 1966, 68: 971-979.","journal-title":"J Pediatr"},{"issue":"53","key":"ref_4","first-page":"861","article-title":"Idiopathic and secondary thrombocytopenic purpura: Clinical study and evaluation of 381 cases over a period of 28 years","volume":"1960","author":"Doan, C.A.; Bouroncle, B.A.; Wiseman, B.K.","unstructured":"Doan, C.A., Bouroncle, B.A. & Wiseman, B.K. Idiopathic and secondary thrombocytopenic purpura: Clinical study and evaluation of 381 cases over a period of 28 years. Ann Intern Med 1960, 53: 861-876.","journal-title":"Ann Intern Med"},{"issue":"171","key":"ref_5","first-page":"1911","article-title":"Treatment of idiopathic thrombocytopenic purpura","volume":"1959","author":"Carpenter, A.F.; Wintrobe, M.M.; Fuller, E.A.; Hart, A.; Cartwright, G.E.","unstructured":"Carpenter, A.F., Wintrobe, M.M., Fuller, E.A., Hart, A. & Cartwright, G.E. Treatment of idiopathic thrombocytopenic purpura. JAMA 1959, 171: 1911-1916.","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/0002-9343(80)90016-9","article-title":"Adult idiopathic thrombocytopenic purpura: clinical findings and response to therapy","volume":"69","author":"Difino, S.M.; Lachant, N.A.; Kirshner, J.J.; Gootleib, A.J.","year":"1980","unstructured":"Difino, S.M., Lachant, N.A., Kirshner, J.J. & Gootleib, A.J. Adult idiopathic thrombocytopenic purpura: clinical findings and response to therapy. Am J Med 1980, 69: 430-442.","journal-title":"Am J Med"},{"issue":"88","key":"ref_7","first-page":"701","article-title":"Idiopathic thrombocytopenia. Review of 89 cases with particular reference to the differentiation and treatment of acute (self limited) and chronic types","volume":"1951","author":"Hirsh, E.O.; Dameshek, W.","unstructured":"Hirsh, E.O. & Dameshek, W. Idiopathic thrombocytopenia. Review of 89 cases with particular reference to the differentiation and treatment of acute (self limited) and chronic types. Arch Int Med 1951, 88: 701-728.","journal-title":"Arch Int Med"},{"issue":"74","key":"ref_8","first-page":"186","article-title":"Subdural hematoma in a 32 year old man with chronic idiopathic thrombocytopenic purpura","volume":"1986","author":"Nagler, A.; Brenner, B.; Hayek, T.; Brook, J.G.","unstructured":"Nagler, A., Brenner, B., Hayek, T. & Brook, J.G. Subdural hematoma in a 32 year old man with chronic idiopathic thrombocytopenic purpura. Acta Haematol (Basel) 1986, 74: 186-187.","journal-title":"Acta Haematol (Basel)"},{"issue":"125 -159","key":"ref_9","article-title":"Idiopathic thrombocytopenic purpura: clinical and immunologic considerations. Semin Thromb Hemost","volume":"3","author":"Mueller-Eckhardt, C.","year":"1977","unstructured":"Mueller-Eckhardt, C. Idiopathic thrombocytopenic purpura: clinical and immunologic considerations. 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Idiopathic thrombocytopenic purpura in childhood: diagnosis and management. Pediatrics 1975, 55: 68-74.","journal-title":"Pediatrics"},{"key":"ref_13","first-page":"p","article-title":"Idiopathic thrombocytopenic purpura","author":"Wintrobe, M.","year":"1974","unstructured":"Wintrobe, M. Idiopathic thrombocytopenic purpura. In Wintrobe, M. (ed) Clinical Hematology, 7th edition. Lea & Febiger, Philadelphia, 1974, p 1075.","edition":"7th edition","journal-title":"Lea & Febiger, Philadelphia; Clinical Hematology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3171\/jns.1976.45.6.0700","article-title":"Management of intracranial haemorrhage in idiopathic thrombocytopenic purpura","volume":"45","author":"Humphreys, R.P.; Hockley, A.D.; Freedman, M.H.; Saunders, E.F.","year":"1976","unstructured":"Humphreys, R.P., Hockley, A.D., Freedman, M.H. & Saunders, E.F. Management of intracranial haemorrhage in idiopathic thrombocytopenic purpura. J Neurosurg 1976, 45: 700-704.","journal-title":"J Neurosurg"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00496806","article-title":"Intracranial hemorrhage simulating brain tumor in immune thrombocytopenic purpura","volume":"141","author":"Lotan, C.S.; Wald, U.; Ludomirsky, A.; Cividalli, G.","year":"1983","unstructured":"Lotan, C.S., Wald, U., Ludomirsky, A. & Cividalli, G. Intracranial hemorrhage simulating brain tumor in immune thrombocytopenic purpura. Eur J Pediatr 1983, 141: 127-128.","journal-title":"Eur J Pediatr"},{"issue":"6","key":"ref_16","first-page":"159","article-title":"Prednisone treatment of acute idiopathic thrombocytopenic purpura in childhood","volume":"1984","author":"Dunn, N.L.; Maurer, H.M.","unstructured":"Dunn, N.L. & Maurer, H.M. Prednisone treatment of acute idiopathic thrombocytopenic purpura in childhood. Advantages. Am J Pediat Hematol Oncol 1984, 6: 159-164.","journal-title":"Advantages. Am J Pediat Hematol Oncol"},{"key":"ref_17","first-page":"187","article-title":"Intravenous gammaglobulin in the treatment of chronic idiopathic thrombocytopenic purpura in adults","volume":"30","author":"Oral, A.; Nusbacher, J.; Hill, J.B.; Lewis, J.H.","year":"1984","unstructured":"Oral, A., Nusbacher, J., Hill, J.B. & Lewis, J.H. Intravenous gammaglobulin in the treatment of chronic idiopathic thrombocytopenic purpura in adults. Am J Med 1984, 30: 187-192.","journal-title":"Am J Med"},{"issue":"51","key":"ref_18","first-page":"182","article-title":"A cooperative clinical trial of high dose immunoglobulin therapy in 177 cases of idiopathic thrombocytopenic purpura","volume":"1984","author":"Mchino, H.; Yasunaga, K.; Akatsuka, J.A.","unstructured":"Mchino, H., Yasunaga, K. & Akatsuka, J.A. A cooperative clinical trial of high dose immunoglobulin therapy in 177 cases of idiopathic thrombocytopenic purpura. Thromb Haemost 1984, 51: 182-519.","journal-title":"Thromb Haemost"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1055\/s-0028-1086135","article-title":"Management of idiopathic thrombocytopenic purpura in the adult","volume":"3","author":"Lacey, J.V.; Penner, J.A.","year":"1977","unstructured":"Lacey, J.V. & Penner, J.A. Management of idiopathic thrombocytopenic purpura in the adult. Semin Thromb Hemost 1977, 3: 160-174.","journal-title":"Semin Thromb Hemost"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1056\/NEJM198105073041904","article-title":"Chronic idiopathic thrombocytopenic purpura","volume":"304","author":"McMillan, R.","year":"1981","unstructured":"McMillan, R. Chronic idiopathic thrombocytopenic purpura. N Engl J Med 1981, 304: 1135-1147.","journal-title":"N Engl J Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/63\/743\/781\/50080337\/postgradmedj-63-781.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/63\/743\/781\/50080337\/postgradmedj-63-781.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T06:38:43Z","timestamp":1684823923000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/63\/743\/781\/7047305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,9,1]]},"references-count":20,"journal-issue":{"issue":"743","published-online":{"date-parts":[[1987,9,1]]},"published-print":{"date-parts":[[1987,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.63.743.781","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1987,9]]},"published":{"date-parts":[[1987,9,1]]}}}