{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:28:21Z","timestamp":1783607301443,"version":"3.55.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"744","license":[{"start":{"date-parts":[[1987,10,1]],"date-time":"1987-10-01T00:00:00Z","timestamp":560044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,10,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We report on a case of ectopic Cushing\u2019s syndrome due to a thymic carcinoid tumour with periodic hormonogenesis. Periods of hormonal production averaged 27 days. Prior to bilateral adrenalectomy, mean (s.d) values of ACTH and cortisol were 202.1 (50.3) pg\/ml and 46 (14.7) micrograms\/dl, ACTH rising to 3996 +\/- 425 pg\/ml (P less than 0.01) and cortisol falling to 6.3 +\/- 1.5 micrograms\/dl (P less than 0.01) in the immediate postoperative period. During the late postoperative period (2-13 months following surgery) ACTH levels fell to 509.3 (123.8) pg\/ml (P less than 0.01), but remaining even higher (P less than 0.01) than before adrenalectomy. The pattern of ACTH in the present case suggests the existence of a negative feedback exerted by the cortisol over tumoral ACTH.<\/jats:p>","DOI":"10.1136\/pgmj.63.744.887","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"887-889","source":"Crossref","is-referenced-by-count":19,"title":["Ectopic Cushing\u2019s syndrome with periodic hormonogenesis--a case suggesting a pathogenetic mechanism"],"prefix":"10.1093","volume":"63","author":[{"given":"V","family":"Estopi\u00f1\u00e1n","sequence":"first","affiliation":[{"name":"Hospital Ram\u00f3n y Cajal , Crtra. Colmenar Viejo, Km. 9,100, 28034-Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Varela","sequence":"additional","affiliation":[{"name":"Hospital Ram\u00f3n y Cajal , Crtra. Colmenar Viejo, Km. 9,100, 28034-Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Riobo","sequence":"additional","affiliation":[{"name":"Hospital Ram\u00f3n y Cajal , Crtra. Colmenar Viejo, Km. 9,100, 28034-Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Hospital Ram\u00f3n y Cajal , Crtra. Colmenar Viejo, Km. 9,100, 28034-Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Sancho","sequence":"additional","affiliation":[{"name":"Hospital Ram\u00f3n y Cajal , Crtra. Colmenar Viejo, Km. 9,100, 28034-Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1987,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"317327","DOI":"10.1210\/jcem-32-3-317","article-title":"Periodic hormonogenesis. A new phenomenon. Periodicity in function ofa hormone-producing tumor in man","volume":"32","author":"Bailey, R.E.","year":"1971","unstructured":"Bailey, R.E. Periodic hormonogenesis. A new phenomenon. Periodicity in function ofa hormone-producing tumor in man. J Clin Endocrinol Metab 1971, 32: 317327.","journal-title":"J Clin Endocrinol Metab"},{"issue":"445 -45","key":"ref_2","article-title":"Cushing's disease with periodic hormonogenesis: one explanation for paradoxical response to dexamethasone","volume":"36","author":"Brown, R.D.; Van Loon, G.R.; Orth, D.N.; Liddle, G.W.","year":"1973","unstructured":"Brown, R.D., Van Loon, G.R., Orth, D.N. & Liddle, G.W. Cushing's disease with periodic hormonogenesis: one explanation for paradoxical response to dexamethasone. J Clin Endocrinol Metab 1973, 36:445 -45l1.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1210\/jcem-43-4-913","article-title":"Periodic remission in Cushing's disease with paradoxical periodic hormonogenesis","volume":"43","author":"Liberman, B.; Wajchenberg, B.L.; Tambascia, M.C.; Mesquita, C.H.","year":"1976","unstructured":"Liberman, B., Wajchenberg, B.L., Tambascia, M.C., Mesquita, C.H. Periodic remission in Cushing's disease with paradoxical periodic hormonogenesis. J Clin Endocrinol Metab 1976, 43: 913-918.","journal-title":"J Clin Endocrinol Metab"},{"issue":"110","key":"ref_4","first-page":"289","article-title":"Cyclic Cushing's syndrome combined with cortisol suppressible dexamethasone non suppressible ACTH secretion: a new variant of Cushing's syndrome","volume":"1985","author":"Schweikert, H.D.; Fehm, H.L.; Fahlbusch, R.","unstructured":"Schweikert, H.D., Fehm, H.L., Fahlbusch, R. et al. Cyclic Cushing's syndrome combined with cortisol suppressible dexamethasone non suppressible ACTH secretion: a new variant of Cushing's syndrome. Acta Endocrinol 1985, 110: 289-295.","journal-title":"Acta Endocrinol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1001\/archinte.1976.03630040043009","article-title":"Cushing's syndrome with cyclical edema and periodic secretion of corticosteroids","volume":"136","author":"Chajeck, T.; Romanoff, H.","year":"1976","unstructured":"Chajeck, T. & Romanoff, H. Cushing's syndrome with cyclical edema and periodic secretion of corticosteroids. Arch Intern Med 1976, 136: 441-443.","journal-title":"Arch Intern Med"},{"key":"ref_6","first-page":"47","article-title":"Cushing's syndrome with a paradoxical response to dexamethasone","volume":"1969","author":"French, F.S.; Macfie, J.A.; Baggett, B.","unstructured":"French, F.S., Macfie, J.A., Baggett, B. et al. Cushing's syndrome with a paradoxical response to dexamethasone. Am J Med 1969, 47: 619-624.","journal-title":"Am J Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1210\/jcem-41-2-235","article-title":"Cushing's syndrome with fluctuation due to adrenal adenoma","volume":"41","author":"Green, J.R.B.; Van't Hoff, W.","year":"1975","unstructured":"Green, J.R.B. & Van't Hoff, W. Cushing's syndrome with fluctuation due to adrenal adenoma. J Clin Endocrinol Metab 1975, 41: 235-240.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1530\/acta.0.0990364","article-title":"A case of ectopic ACTH syndrome: diagnostic difficulties caused by intermittent hormone secretion","volume":"99","author":"Thorner, M.; Martin, W.H.; Ragan, G.E.","year":"1982","unstructured":"Thorner, M., Martin, W.H., Ragan, G.E. et al. A case of ectopic ACTH syndrome: diagnostic difficulties caused by intermittent hormone secretion. Acta Endocrinol 1982, 99: 364-370.","journal-title":"Acta Endocrinol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0002-9343(72)90149-0","article-title":"Studies in a case of Cushing's syndrome due to an ACTH-producing thymic tumour","volume":"53","author":"Pimstone, B.L.; Uys, C.J.; Vogelpoel, L.","year":"1972","unstructured":"Pimstone, B.L., Uys, C.J. & Vogelpoel, L. Studies in a case of Cushing's syndrome due to an ACTH-producing thymic tumour. Am J Med 1972, 53: 521-528.","journal-title":"Am J Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJM197704142961508","article-title":"Selective venous sampling to differentiate ectopic ACTH secretion from pituitary Cushing's syndrome","volume":"296","author":"Corrigan, D.F.; Schaaf, M.; Whaley, R.A.; Czerwinski, C.L.; Earl, J.M.","year":"1977","unstructured":"Corrigan, D.F., Schaaf, M., Whaley, R.A., Czerwinski, C.L. & Earl, J.M. Selective venous sampling to differentiate ectopic ACTH secretion from pituitary Cushing's syndrome. N Engl J Med 1977, 296: 861-862.","journal-title":"N Engl J Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/63\/744\/887\/50080522\/postgradmedj-63-887.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/63\/744\/887\/50080522\/postgradmedj-63-887.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T05:03:53Z","timestamp":1683263033000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/63\/744\/887\/7047188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10,1]]},"references-count":10,"journal-issue":{"issue":"744","published-online":{"date-parts":[[1987,10,1]]},"published-print":{"date-parts":[[1987,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.63.744.887","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1987,10]]},"published":{"date-parts":[[1987,10,1]]}}}