{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:26:04Z","timestamp":1777332364759,"version":"3.51.4"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"748","license":[{"start":{"date-parts":[[1988,2,1]],"date-time":"1988-02-01T00:00:00Z","timestamp":570672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 23 year old man presented with a tumour mass in the lung. Subsequent investigation showed ectopic secretion of adrenocorticotrophic hormone (ACTH) and growth hormone releasing hormone (GHRH) from an adenoid cystic carcinoma. The patient progressed to show the clinical effects of long term exposure to high blood levels of both growth hormone and cortisol. The case was complicated by pituitary infarction. The very high blood levels of ACTH, growth hormone (GH) and GHRH proved resistant to treatment with the somatostatin analogue, SMS 201-995, and a possible side effect of the drug is reported. To our knowledge this is the first reported case of ectopic hormone secretion by an adenoid cystic carcinoma.<\/jats:p>","DOI":"10.1136\/pgmj.64.748.145","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"145-148","source":"Crossref","is-referenced-by-count":18,"title":["Ectopic release of GHRH and ACTH from an adenoid cystic carcinoma resulting in acromegaly and complicated by pituitary infarction"],"prefix":"10.1093","volume":"64","author":[{"given":"H J","family":"Southgate","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, St. Luke\u2019s Hospital , Guildford, Surrey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G P R","family":"Archbold","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, St. Luke\u2019s Hospital , Guildford, Surrey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E","family":"El-Sayed","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, St. Luke\u2019s Hospital , Guildford, Surrey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, St. Luke\u2019s Hospital , Guildford, Surrey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Marks","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, St. Luke\u2019s Hospital , Guildford, Surrey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1172\/JCI109658","article-title":"Partial purification and characterisation of a peptide with growth-hormone releasing activity from extrapituitary tumours in patients with acromegaly","volume":"65","author":"Frohman, L.A.; Szabo, M.; Berelowitz, M.; Stachura, M.E.","year":"1980","unstructured":"Frohman, L.A., Szabo, M., Berelowitz, M. & Stachura, M.E. Partial purification and characterisation of a peptide with growth-hormone releasing activity from extrapituitary tumours in patients with acromegaly. J Clin Invest 1980, 65: 43-54.","journal-title":"J Clin Invest"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1172\/JCI110708","article-title":"Somatotroph hyperplasia: Successful treatment of acromegaly by removal of pancreatic islet cell tumours secreting a growth hormone releasing factor","volume":"70","author":"Thorner, M.D.; Perryman, R.L.; Cronin, M.J.","year":"1982","unstructured":"Thorner, M.D., Perryman, R.L., Cronin, M.J. et al. Somatotroph hyperplasia: Successful treatment of acromegaly by removal of pancreatic islet cell tumours secreting a growth hormone releasing factor. J Clin Invest 1982, 70: 965-977.","journal-title":"J Clin Invest"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1126\/science.6812220","article-title":"Growth hormone releasing factor from a human pancreatic tumour that caused acromegaly","volume":"218","author":"Guillemin, R.; Brazeau, P.; Bohlen, P.","year":"1982","unstructured":"Guillemin, R., Brazeau, P., Bohlen, P. et al. Growth hormone releasing factor from a human pancreatic tumour that caused acromegaly. Science 1982, 218: 585-587.","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/300276a0","article-title":"Characterisation of a growth hormone releasing factor from a human pancreatic islet cell tumour","volume":"300","author":"Rivier, J.; Speiss, J.; Thorner, M.; Vale, W.","year":"1982","unstructured":"Rivier, J., Speiss, J., Thorner, M. & Vale, W. Characterisation of a growth hormone releasing factor from a human pancreatic islet cell tumour. 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N Engl J Med 1974, 290: 935.","journal-title":"N Engl J Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1210\/jcem-51-3-616","article-title":"Homogeneity in growth hormone lowering effect of dopamine and somatostatin in acromegaly","volume":"51","author":"Oppizzi, G.; Botalla, L.; Verde, G.","year":"1980","unstructured":"Oppizzi, G., Botalla, L., Verde, G. et al. Homogeneity in growth hormone lowering effect of dopamine and somatostatin in acromegaly. J Clin Endocrinol Metab 1980, 51: 616-619.","journal-title":"J Clin Endocrinol Metab"},{"issue":"60","key":"ref_13","first-page":"1161","article-title":"The somatostatin analogue SMS 201-995 induces long acting inhibition of growth hormone secretion without hypersecretion in acromegaloid patients","volume":"1985","author":"Lamberts, S.W.J.; Oosterom, R.; Neufeld, M.; DelPozo, E.","unstructured":"Lamberts, S.W.J., Oosterom, R., Neufeld, M. & DelPozo, E. 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Human pancreatic growth hormone releasing factor (1-40) allows stimulation of GH release by TRH. J Endocrinol 1983, 113: 1519.","journal-title":"J Endocrinol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1056\/NEJM198609113151102","article-title":"Treatment of the malignant carcinoid syndrome. Evaluation of a long acting somatostatin analogue","volume":"315","author":"Kvols, L.K.; Moertel, C.G.; O'Connell, M.J.","year":"1986","unstructured":"Kvols, L.K., Moertel, C.G., O'Connell, M.J. et al. Treatment of the malignant carcinoid syndrome. Evaluation of a long acting somatostatin analogue. N Engl J Med 1986, 315: 663-666.","journal-title":"N Engl J Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/748\/145\/50078294\/postgradmedj-64-145.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/748\/145\/50078294\/postgradmedj-64-145.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T14:16:09Z","timestamp":1683209769000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/64\/748\/145\/7047695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,2,1]]},"references-count":17,"journal-issue":{"issue":"748","published-online":{"date-parts":[[1988,2,1]]},"published-print":{"date-parts":[[1988,2,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.64.748.145","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1988,2]]},"published":{"date-parts":[[1988,2,1]]}}}