{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:52:58Z","timestamp":1760028778925},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"749","license":[{"start":{"date-parts":[[1988,3,1]],"date-time":"1988-03-01T00:00:00Z","timestamp":573177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,3,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Severe generalized myalgias and muscle contractures of the lower extremities were the major initial manifestations of adrenal insufficiency in a 26 year old black male. The intensity of increased skin pigmentation was not fully appreciated until the patient\u2019s skin colour was compared to that of his brother. Replacement with physiological doses of gluco- and mineralocorticoids was associated with complete amelioration of symptomatology.<\/jats:p>","DOI":"10.1136\/pgmj.64.749.222","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"222-223","source":"Crossref","is-referenced-by-count":15,"title":["Myalgias and muscle contractures as the presenting signs of Addison\u2019s disease"],"prefix":"10.1093","volume":"64","author":[{"given":"M S","family":"Shapiro","sequence":"first","affiliation":[{"name":"Department of Medicine C and the Endocrine Unit, Meir Hospital, Sapir Medical Center, Kfar Sava, and the Sackler School of Medicine, Tel Aviv, University , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Trebich","sequence":"additional","affiliation":[{"name":"Department of Medicine C and the Endocrine Unit, Meir Hospital, Sapir Medical Center, Kfar Sava, and the Sackler School of Medicine, Tel Aviv, University , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Shilo","sequence":"additional","affiliation":[{"name":"Department of Medicine C and the Endocrine Unit, Meir Hospital, Sapir Medical Center, Kfar Sava, and the Sackler School of Medicine, Tel Aviv, University , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Shenkman","sequence":"additional","affiliation":[{"name":"Department of Medicine C and the Endocrine Unit, Meir Hospital, Sapir Medical Center, Kfar Sava, and the Sackler School of Medicine, Tel Aviv, University , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,3,1]]},"reference":[{"issue":"16","key":"ref_1","first-page":"1053","article-title":"Addison's disease: evaluation of synthetic desoxycorticosterone acetate therapy in 158 patients","volume":"1942","author":"Thorn, W.G.; Dorrance, S.S.; Day, E.","unstructured":"Thorn, W.G., Dorrance, S.S. & Day, E. 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Acta Endocrinol 1966, 53: 489498.","journal-title":"Acta Endocrinol"},{"issue":"49","key":"ref_10","first-page":"13","article-title":"Flexion contracture in adrenal insufficiency","volume":"1968","author":"Susac, J.O.; Henry, J.M.; Deller, J.J.","unstructured":"Susac, J.O., Henry, J.M. & Deller, J.J. Flexion contracture in adrenal insufficiency. Arch Phys Med Rehabil 1968, 49: 13-16.","journal-title":"Arch Phys Med Rehabil"},{"key":"ref_11","first-page":"329","article-title":"Addison's disease: A review of its clinical course and management","volume-title":"The Human Adrenal Cortex","author":"Knowlton, A.I.","year":"1971","unstructured":"Knowlton, A.I. Addison's disease: A review of its clinical course and management. In: Christy, N.C. (ed) The Human Adrenal Cortex. Harper and Row, New York, 1971, p 329."},{"key":"ref_12","first-page":"2","article-title":"Symptomatology resulting from withdrawal of steroid hormone therapy","volume":"1959","author":"Good, T.A.; Benton, J.W.; Kelley, V.C.","unstructured":"Good, T.A., Benton, J.W. & Kelley, V.C. Symptomatology resulting from withdrawal of steroid hormone therapy. Arth Rheum 1959, 2: 299-301.","journal-title":"Arth Rheum"},{"issue":"1","key":"ref_13","first-page":"1579","article-title":"Adrenal function after prolonged corticosteroid","volume":"1962","author":"Robinson, B.H.B.; Mattingly, D.; Cope, C.L.","unstructured":"Robinson, B.H.B., Mattingly, D. & Cope, C.L. Adrenal function after prolonged corticosteroid therapy, Br Med J 1962, 1: 1579-1584.","journal-title":"therapy, Br Med J"},{"key":"ref_14","article-title":"In: The Diagnosis and Treatment of Adrenal Insufficiency. Charles C","author":"Thorn, G.W.","year":"1949","unstructured":"Thorn, G.W. 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Thomas, Springfield, Illinois, 1949."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/749\/222\/50078306\/postgradmedj-64-222.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/749\/222\/50078306\/postgradmedj-64-222.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T02:36:34Z","timestamp":1683254194000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/64\/749\/222\/7047618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3,1]]},"references-count":14,"journal-issue":{"issue":"749","published-online":{"date-parts":[[1988,3,1]]},"published-print":{"date-parts":[[1988,3,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.64.749.222","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1988,3]]},"published":{"date-parts":[[1988,3,1]]}}}