{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:39:34Z","timestamp":1760042374598},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"749","license":[{"start":{"date-parts":[[1988,3,1]],"date-time":"1988-03-01T00:00:00Z","timestamp":573177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,3,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The case is reported of a patient who developed severe hypokalaemia, leading to cardiac arrest, while receiving mithramycin for painful Paget\u2019s disease. The patient was also receiving antihypertensive and anti-anginal treatment including bendrofluazide, but plasma potassium before the administration of mithramycin was normal. Hypokalaemia has been reported in previous studies of the use of mithramycin but has received little attention. The drug should be used with great care in patients with cardiovascular disease and in those receiving diuretics.<\/jats:p>","DOI":"10.1136\/pgmj.64.749.228","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"228-229","source":"Crossref","is-referenced-by-count":1,"title":["Cardiac arrest associated with hypokalaemia in a patient receiving mithramycin"],"prefix":"10.1093","volume":"64","author":[{"given":"Y","family":"Bashir","sequence":"first","affiliation":[{"name":"Department of Neurology, General Hospital, Newcastle on Tyne , Newcastle on Tyne NEI 4LP , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C R V","family":"Tomson","sequence":"additional","affiliation":[{"name":"Home Dialysis Office, Royal Victoria Infirmary , Newcastle on Tyne NEI 4LP , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,3,1]]},"reference":[{"issue":"70","key":"ref_1","first-page":"549","article-title":"Effects of mithramycin on Paget's disease of bone","volume":"1969","author":"Ryan, W.G.; Schwartz, T.B.; Perlia, C.P.","unstructured":"Ryan, W.G., Schwartz, T.B. & Perlia, C.P. Effects of mithramycin on Paget's disease of bone. Ann Intern Med 1969, 70: 549-557.","journal-title":"Ann Intern Med"},{"issue":"5","key":"ref_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0221-8747(81)90051-5","article-title":"The role of mithramycin in the management of Paget's disease","volume":"4","author":"Heath, D.A.","year":"1981","unstructured":"Heath, D.A. The role of mithramycin in the management of Paget's disease. Metab Bone Dis Relat Res 1981, 4 & 5: 343-345.","journal-title":"Metab Bone Dis Relat Res"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1001\/jama.1970.03170330035004","article-title":"Experiences in the treatment of Paget's disease of bone with mithramycin","volume":"213","author":"Ryan, W.G.; Schwartz, T.B.; Northrop, G.","year":"1970","unstructured":"Ryan, W.G., Schwartz, T.B. & Northrop, G. Experiences in the treatment of Paget's disease of bone with mithramycin. JAMA 1970, 213: 1153-1157.","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.2106\/00004623-197254080-00013","article-title":"Mithramycin in the treatment of Paget's disease of bone","volume":"54","author":"Elias, E.G.; Evans, J.T.","year":"1972","unstructured":"Elias, E.G. & Evans, J.T. Mithramycin in the treatment of Paget's disease of bone. J Bone Joint Surg (Am) 1972, 54: 1730-1736.","journal-title":"J Bone Joint Surg (Am)"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1159\/000221817","article-title":"Renal function and alterations in plasma electrolyte levels in normocalcaemic and hypercalcaemic patients with malignant diseases given intravenous infusion of mithramycin","volume":"20","author":"Fillastre, J.P.; Maitrot, J.; Lannone, M.A.","year":"1974","unstructured":"Fillastre, J.P., Maitrot, J., Lannone, M.A. et al. Renal function and alterations in plasma electrolyte levels in normocalcaemic and hypercalcaemic patients with malignant diseases given intravenous infusion of mithramycin. Chemotherapy 1974, 20: 280-295.","journal-title":"Chemotherapy"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0140-6736(82)90930-8","article-title":"Acute transient hypokalaemia: new interpretation of a common event","volume":"ii:","author":"Morgan, D.B.; Young, R.M.","year":"1982","unstructured":"Morgan, D.B. & Young, R.M. Acute transient hypokalaemia: new interpretation of a common event. Lancet 1982, ii: 751-752.","journal-title":"Lancet"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/749\/228\/50078374\/postgradmedj-64-228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/749\/228\/50078374\/postgradmedj-64-228.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T02:36:41Z","timestamp":1683254201000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/64\/749\/228\/7047600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3,1]]},"references-count":6,"journal-issue":{"issue":"749","published-online":{"date-parts":[[1988,3,1]]},"published-print":{"date-parts":[[1988,3,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.64.749.228","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1988,3]]},"published":{"date-parts":[[1988,3,1]]}}}