{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:35:36Z","timestamp":1762004136346},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"749","license":[{"start":{"date-parts":[[1988,3,1]],"date-time":"1988-03-01T00:00:00Z","timestamp":573177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,3,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>In the majority of cases plasma cell leukaemia is a rapidly fatal disease with a mean survival time of five months. There have been reports of increased survival using various regimens of chemotherapy although most cases eventually relapse. We describe a patient with primary plasma cell leukaemia who responded to a combination of oral melphalan and prednisolone with control of the disease in the bone marrow but relapsed with extramedullary disease in the central nervous system and testes, and died 22 months after diagnosis. Melphalan poorly penetrates the central nervous system and its testicular penetration is unknown.<\/jats:p>","DOI":"10.1136\/pgmj.64.749.232","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"232-235","source":"Crossref","is-referenced-by-count":3,"title":["Survival of twenty-two months in a patient with primary plasma cell leukaemia treated with melphalan and prednisolone"],"prefix":"10.1093","volume":"64","author":[{"given":"J D","family":"Walker","sequence":"first","affiliation":[{"name":"Chelmsford Hospitals , Chelmsford, Essex , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R S","family":"Kaczmarski","sequence":"additional","affiliation":[{"name":"Chelmsford Hospitals , Chelmsford, Essex , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000206705","article-title":"Primary plasma cell leukaemia. 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Unusual remission after radiophosphorus therapy in a case of 'acute plasma cell leukaemia'. Blood 1948, 3: 1019-1024.","journal-title":"Blood"},{"key":"ref_26","first-page":"136","article-title":"Plasma cell leukaemia. Diagnostic problems in our experience with 11 cases","volume":"63","author":"Toma, V.A.; Retief, F.P.; Potgieter, G.M.; Anderson, J.D.","year":"1980","unstructured":"Toma, V.A., Retief, F.P., Potgieter, G.M. & Anderson, J.D. Plasma cell leukaemia. Diagnostic problems in our experience with 11 cases. Acta Haematol 1980, 63: 136-145.","journal-title":"Acta Haematol"},{"issue":"16","key":"ref_27","first-page":"607","article-title":"Growth rates and responses to treatment in human myelomatosis","volume":"1969","author":"Hobbs, J.R.","unstructured":"Hobbs, J.R. Growth rates and responses to treatment in human myelomatosis. Br J Haematol 1969, 16: 607-617.","journal-title":"Br J Haematol"},{"key":"ref_28","first-page":"558","article-title":"Mieloma de BenceJones con derrame pleural bilateral y leucemia de celulas plasmaticas","volume":"4","author":"Martin, C.; Orburch, S.; De Pizwlatto, M.B.; Fuchs, C.R.; Battilare, N.; Pinto, M.T.","year":"1982","unstructured":"Martin, C., Orburch, S., De Pizwlatto, M.B., Fuchs, C.R., Battilare, N. & Pinto, M.T. Mieloma de BenceJones con derrame pleural bilateral y leucemia de celulas plasmaticas. Sangre 1982, 4: 558-563.","journal-title":"Sangre"},{"key":"ref_29","first-page":"256","article-title":"Testicular leukaemia and temperature","volume":"ii:","author":"Van Eys, J.; Sullivan, M.P.","year":"1976","unstructured":"Van Eys, J. & Sullivan, M.P. Testicular leukaemia and temperature. Lancet 1976, ii: 256-257.","journal-title":"Lancet"},{"key":"ref_30","first-page":"674","article-title":"Sanctuary therapy. 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Cancer 1952, 5: 514.","journal-title":"Cancer"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/749\/232\/50078503\/postgradmedj-64-232.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/749\/232\/50078503\/postgradmedj-64-232.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T02:36:48Z","timestamp":1683254208000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/64\/749\/232\/7047606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3,1]]},"references-count":32,"journal-issue":{"issue":"749","published-online":{"date-parts":[[1988,3,1]]},"published-print":{"date-parts":[[1988,3,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.64.749.232","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1988,3]]},"published":{"date-parts":[[1988,3,1]]}}}