{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:12:52Z","timestamp":1762917172711},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"749","license":[{"start":{"date-parts":[[1988,3,1]],"date-time":"1988-03-01T00:00:00Z","timestamp":573177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,3,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A laboratory technician developed leptospirosis following accidental inoculation, despite prompt administration of parenteral penicillin by an accepted regimen of post-exposure prophylaxis. Another technician was similarly exposed and was given doxycycline; no illness or serological conversion followed. The implications of these cases are discussed and recommendations made for post-exposure chemoprophylaxis with doxycycline.<\/jats:p>","DOI":"10.1136\/pgmj.64.749.236","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"236-238","source":"Crossref","is-referenced-by-count":21,"title":["Failure of penicillin prophylaxis in laboratory acquired leptospirosis"],"prefix":"10.1093","volume":"64","author":[{"given":"C F","family":"Gilks","sequence":"first","affiliation":[{"name":"St. George\u2019s Hospital , London SW17 ORE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H P","family":"Lambert","sequence":"additional","affiliation":[{"name":"St. George\u2019s Hospital , London SW17 ORE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E S","family":"Broughton","sequence":"additional","affiliation":[{"name":"Wellcome Research Laboratories , Kent , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C C","family":"Baker","sequence":"additional","affiliation":[{"name":"Wellcome Research Laboratories , Kent , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3109\/10408367509107050","article-title":"Human leptospirosis","volume":"5","author":"Feigin, R.D.; Anderson, D.C.","year":"1975","unstructured":"Feigin, R.D. & Anderson, D.C. 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Trans R Soc Trop Med Hyg 1967, 61: 842-854.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref_5","article-title":"Guidelines for the Control of Leptospirosis","volume":"67","author":"Faine, S.","year":"1982","unstructured":"Faine, S. (ed) Guidelines for the Control of Leptospirosis. WHO Offset Publication, 1982, No. 67, WHO, Geneva.","journal-title":"WHO Offset Publication"},{"key":"ref_6","first-page":"721","article-title":"Failure of prophylactic penicillin to inhibit a human laboratory case of leptospirosis","volume":"i:","author":"Broom, J.B.; Norris, T.St M.","unstructured":"Broom, J.B. & Norris, T.St.M. Failure of prophylactic penicillin to inhibit a human laboratory case of leptospirosis. 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Butterworths, London, 1983."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00007611-197402000-00007","article-title":"Infection by Leptospira ballum: a laboratory acquired associated case","volume":"67","author":"Barkin, R.M.; Guckian, J.C.; Gosser, J.W.","year":"1974","unstructured":"Barkin, R.M., Guckian, J.C. & Gosser, J.W. Infection by Leptospira ballum: a laboratory acquired associated case. South Med J 1974, 67: 155.","journal-title":"South Med J"},{"issue":"101","key":"ref_10","first-page":"606","article-title":"Leptospirosis (Ballum), contracted from Swiss Albino mice","volume":"1958","author":"Stoenner, H.G.; Maclean, D.","unstructured":"Stoenner, H.G. & Maclean, D. Leptospirosis (Ballum), contracted from Swiss Albino mice. Arch Int Med 1958, 101: 606-610.","journal-title":"Arch Int Med"},{"key":"ref_11","article-title":"Laboratoriums infektionen mit Weilscher Krakheit. Zbl Bakt abl Orig 1934, 141, 400-410. Quoted in","author":"Welcker, A.","year":"8).","unstructured":"Welcker, A. Laboratoriums infektionen mit Weilscher Krakheit. Zbl Bakt abl Orig 1934, 141, 400-410. Quoted in Collins (Reference 8)."},{"issue":"51","key":"ref_12","first-page":"216","article-title":"Chloramphenicol in the chemoprophylaxis of scrub typhus (tsutsugamusohi disease) III. Suppression of overt disease by prophylactic regimens of four weeks duration","volume":"1950","author":"Smadel, J.E.; Traub, R.; Frick, L.P.; Diercks, F.H.; Bailey, C.A.","unstructured":"Smadel, J.E., Traub, R., Frick, L.P., Diercks, F.H. & Bailey, C.A. Chloramphenicol in the chemoprophylaxis of scrub typhus (tsutsugamusohi disease) III. Suppression of overt disease by prophylactic regimens of four weeks duration. 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