{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T07:10:08Z","timestamp":1684825808476},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"751","license":[{"start":{"date-parts":[[1988,5,1]],"date-time":"1988-05-01T00:00:00Z","timestamp":578448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,5,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Classical insulin-dependent diabetes mellitus (IDDM) is relatively uncommon in Indian-Asians whether in India or in the UK and this may be related to immunogenetic factors. We have studied the presence or absence of islet cell antibodies and other auto-antibodies in 36 subjects with IDDM and 41 controls, all of Indian origin. Islet cell antibodies (ICA-IgG) were found in 8 subjects with IDDM but in none of the controls. Four of the 8 patients with ICA-IgG also possessed the complement fixing variety (CF-ICA). There was no definite association between possession of ICA and HLA-DR antigens. Thyroid antibodies were commoner in patients (22%) compared with controls (7%) as were parietal cell antibodies (8.3% vs 4.8%). None of the patients or controls had adrenal antibodies.<\/jats:p><jats:p>The frequency of organ-specific antibodies in Indian-Asians with IDDM is similar to that of white Caucasians. The overall frequency of ICA is, however, lower than that reported for white Caucasians although the temporal distribution is similar. We conclude that even though the prevalence of IDDM in Indian-Asians is lower than in white Caucasians there is no evidence that different immunological mechanisms are involved in the pathogenesis of IDDM in the two groups.<\/jats:p>","DOI":"10.1136\/pgmj.64.751.357","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"357-360","source":"Crossref","is-referenced-by-count":5,"title":["Autoantibodies in Indian-Asians with insulin-dependent diabetes in the UK"],"prefix":"10.1093","volume":"64","author":[{"given":"O","family":"Odugbesan","sequence":"first","affiliation":[{"name":"Department of Medicine , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Medicine , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Immunology, Middlesex Hospital Medical School London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A R","family":"Bradwell","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Birmingham and East Birmingham Hospital , Birmingham , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G F","family":"Botazzo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Middlesex Hospital Medical School London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A H","family":"Barnett","sequence":"additional","affiliation":[{"name":"Department of Medicine , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,5,1]]},"reference":[{"key":"ref_1","first-page":"1279","article-title":"Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies","volume":"ii:","author":"Bottazzo, G.F.; Florin-Christensen, A.; Doniach, D.","year":"1974","unstructured":"Bottazzo, G.F., Florin-Christensen, A. & Doniach, D. Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 1974, ii: 1279-1282.","journal-title":"Lancet"},{"key":"ref_2","first-page":"205","article-title":"Immunity and autoimmunity in diabetes mellitus","volume":"6","author":"Christy, M.; Deckert, T.; Nerup, J.","year":"1977","unstructured":"Christy, M., Deckert, T. & Nerup, J. Immunity and autoimmunity in diabetes mellitus. Clin Endocrinol Metab 1977, 6: 205-332.","journal-title":"Clin Endocrinol Metab"},{"key":"ref_3","first-page":"224","article-title":"The genetic susceptibility to type 1 (insulin-dependent) diabetes: analysis of the HLA-DR association","volume":"24","author":"Wolf, E.; Spencer, K.M.; Cudworth, A.G.","year":"1983","unstructured":"Wolf, E., Spencer, K.M. & Cudworth, A.G. The genetic susceptibility to type 1 (insulin-dependent) diabetes: analysis of the HLA-DR association. Diabetologia 1983, 24: 224-230.","journal-title":"Diabetologia"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.2337\/diab.29.8.589","article-title":"Islet cell and other organ specific antibodies in US Caucasians and Blacks with insulin dependent diabetes mellitus","volume":"29","author":"Neufeld, M.; MacLaren, N.K.; Riley, W.J.","year":"1980","unstructured":"Neufeld, M., MacLaren, N.K., Riley, W.J. et al. Islet cell and other organ specific antibodies in US Caucasians and Blacks with insulin dependent diabetes mellitus. Diabetes 1980, 29: 589-592.","journal-title":"Diabetes"},{"key":"ref_5","first-page":"159","article-title":"Some genetic and immunological aspects of type 1 (insulin-dependent) diabetes in Japan","volume-title":"Immunology in Diabetes. Kimpton Medical","author":"Kanazawa, Y.","year":"1984","unstructured":"Kanazawa, Y. Some genetic and immunological aspects of type 1 (insulin-dependent) diabetes in Japan. In: Adreani, D., DiMario, U., Federlin, K.F. & Heding, L.G. (eds) Immunology in Diabetes. Kimpton Medical, London, 1984, pp 159-169."},{"issue":"290","key":"ref_6","first-page":"10511052","article-title":"Asian patients attending a diabetic clinic","volume":"1985","author":"Odugbesan, 0. & Barnett, A. H","unstructured":"Odugbesan, 0. & Barnett, A.H. Asian patients attending a diabetic clinic. Br Med J 1985, 290: 10511052.","journal-title":"Br Med J"},{"issue":"290","key":"ref_7","first-page":"1081","article-title":"The Southall Diabetes Survey: prevalence of known diabetes in Asians and Europeans","volume":"1985","author":"Mather, H.M.; Keen, K.","unstructured":"Mather, H.M. & Keen, K. The Southall Diabetes Survey: prevalence of known diabetes in Asians and Europeans. Br Med J 1985, 290: 1081-1084.","journal-title":"Br Med J"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/BF00277317","article-title":"The HLA-D associations of Type 1 (insulin dependent) diabetes in Punjabi Asians in the United Kingdom","volume":"30","author":"Odugbesan, O.; Fletcher, J.; Mijovic, C.; MacKay, E.; Bradwell, A.R.; Barnett, A.H.","year":"1987","unstructured":"Odugbesan, O., Fletcher, J., Mijovic, C., MacKay, E., Bradwell, A.R. & Barnett, A.H. The HLA-D associations of Type 1 (insulin dependent) diabetes in Punjabi Asians in the United Kingdom. Diabetologia 1987, 30: 618-621.","journal-title":"Diabetologia"},{"issue":"1","key":"ref_9","first-page":"139","article-title":"Humoral and cellular immunity in diabetes mellitus","volume":"1981","author":"Bottazzo, G.F.; Pujol-Borrell, R.; Doniach, D.","unstructured":"Bottazzo, G.F., Pujol-Borrell, R. & Doniach, D. Humoral and cellular immunity in diabetes mellitus. Clinics Immunol Allerg 1981, 1: 139-159.","journal-title":"Clinics Immunol Allerg"},{"issue":"28","key":"ref_10","first-page":"125","article-title":"Immunology and Diabetes Workshops. Report of the first International Workshop on the standardisation of cytoplasmic islet cell antibodies","volume":"1986","author":"Bottazzo, G.F.; Gleichman, H.","unstructured":"Bottazzo, G.F. & Gleichman, H. Immunology and Diabetes Workshops. Report of the first International Workshop on the standardisation of cytoplasmic islet cell antibodies. Diabetologia 1986, 28: 125-126.","journal-title":"Diabetologia"},{"key":"ref_11","first-page":"456","article-title":"Immunocytochemistry in the study and diagnosis of organ-specific autoimmune disease","author":"Schezbaum, W.A.; Kizokian, R.; Pujol-Burrell, R.; Dean, B.M.; Bottazzo, G.F.","year":"1986","unstructured":"Schezbaum, W.A., Kizokian, R., Pujol-Burrell, R., Dean, B.M. & Bottazzo, G.F. Immunocytochemistry in the study and diagnosis of organ-specific autoimmune disease. In: Polak, J.M. & Van Norden, S. (eds) Immunocytochemistry, Modern Methods and Applications. J. Wright and Sons, Bristol, 1986, pp 456-476.","journal-title":"Immunocytochemistry, Modern Methods and Applications. J. Wright and Sons, Bristol"},{"key":"ref_12","first-page":"37","article-title":"Serological detection of HLA-D locus related (DR) gene products","volume-title":"Detection of Immune Associated Genetic Markers of Human Disease","author":"Tait, B.D.; Simons, M.J.","year":"1984","unstructured":"Tait, B.D. & Simons, M.J. Serological detection of HLA-D locus related (DR) gene products. In: Simons, M.J. & Tait, B.D. (eds) Detection of Immune Associated Genetic Markers of Human Disease. Churchill Livingstone, London, 1984, pp 37-45."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1464-5491.1987.tb00832.x","article-title":"Prevalence of insulin dependent diabetes mellitus in Asian children","volume":"4","author":"Samanta, A.; Burden, A.C.Jones; R, G.","year":"1987","unstructured":"Samanta, A., Burden, A.C. Jones, G.R. et al. Prevalence of insulin dependent diabetes mellitus in Asian children. Diabetic Medicine 1987, 4: 65-67.","journal-title":"Diabetic Medicine"},{"key":"ref_14","first-page":"90","article-title":"Immunogenetics of insulin dependent diabetes - racial differences","volume-title":"Immunogenetics of Insulin Dependent Diabetes","author":"Odugbesan, 0. & Barnett, A. H","year":"1987","unstructured":"Odugbesan, 0. & Barnett, A.H. Immunogenetics of insulin dependent diabetes - racial differences. In: Barnett, A.H. (ed) Immunogenetics of Insulin Dependent Diabetes. MTP Press, 1987, pp. 90-100."},{"issue":"9","key":"ref_15","first-page":"435","article-title":"Autoimmunity in South Indian patients with IDDM","volume":"1986","author":"Ramachandran, A.; Rosenbloom, A.L.; Mohan, V.","unstructured":"Ramachandran, A., Rosenbloom, A.L., Mohan, V. et al. Autoimmunity in South Indian patients with IDDM. Diabetes Care 1986, 9: 435.","journal-title":"Diabetes Care"},{"issue":"34","key":"ref_16","first-page":"565","article-title":"HLA-DR antigen frequencies in a north Indian type 1 diabetic population","volume":"1985","author":"Bhatia, E.; Melira, N.K.; Taheja, V.; Vaidya, M.C.; Ahuja, M.M.S.","unstructured":"Bhatia, E., Melira, N.K., Taheja, V., Vaidya, M.C. & Ahuja, M.M.S. HLA-DR antigen frequencies in a north Indian type 1 diabetic population. Diabetes 1985, 34: 565-567.","journal-title":"Diabetes"},{"key":"ref_17","first-page":"126","article-title":"Islet cell antibodies and other autoantibodies in South African blacks and Indians with insulin dependent diabetes mellitus (IDDM)","volume":"18","author":"Omar, M.A.K.; Bottazzo, G.F.; Asmal, A.C.","year":"1980","unstructured":"Omar, M.A.K., Bottazzo, G.F. & Asmal, A.C. Islet cell antibodies and other autoantibodies in South African blacks and Indians with insulin dependent diabetes mellitus (IDDM). Horm Metab Res 1980, 18: 126-128.","journal-title":"Horm Metab Res"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/bmj.280.6208.145","article-title":"Evidence that type 1 diabetes and thyrogastric autoimmunity have different genetic determinants","volume":"280","author":"Gorsuch, A.N.; Dean, B.M.; Bottazzo, G.F.; Lister, J.; Cudworth, A.G.","year":"1980","unstructured":"Gorsuch, A.N., Dean, B.M., Bottazzo, G.F., Lister, J. & Cudworth, A.G. Evidence that type 1 diabetes and thyrogastric autoimmunity have different genetic determinants. Br Med J 1980, 280: 145-147.","journal-title":"Br Med J"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/751\/357\/50078458\/postgradmedj-64-357.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/751\/357\/50078458\/postgradmedj-64-357.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T06:43:28Z","timestamp":1684824208000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/64\/751\/357\/7047829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5,1]]},"references-count":18,"journal-issue":{"issue":"751","published-online":{"date-parts":[[1988,5,1]]},"published-print":{"date-parts":[[1988,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.64.751.357","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1988,5]]},"published":{"date-parts":[[1988,5,1]]}}}