{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:40:31Z","timestamp":1760298031626},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"751","license":[{"start":{"date-parts":[[1988,5,1]],"date-time":"1988-05-01T00:00:00Z","timestamp":578448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Alveolar soft-part sarcoma is a rare, slow-growing, malignant tumour which metastasizes frequently to the lungs. Treatment with radiotherapy or chemotherapy is largely ineffective, and most patients die within 4 years of developing metastases. We report an unusual patient who survived 9 years after detection of pulmonary metastases. Initial treatment with cytotoxic chemotherapy was ineffective. However, during subsequent treatment with Chinese herbs when she developed galactorrhoea and amenorrhoea (probably due to drug-induced hyperprolactinaemia), her lung metastases regressed, and it is likely that this contributed to her prolonged survival. We hypothesize that alveolar soft-part sarcoma may be a hormone-sensitive tumour, and hormonal manipulation may be an alternative form of treatment which is worth considering.<\/jats:p>","DOI":"10.1136\/pgmj.64.751.386","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"386-388","source":"Crossref","is-referenced-by-count":5,"title":["Alveolar soft-part sarcoma: a hormone-sensitive tumour?"],"prefix":"10.1093","volume":"64","author":[{"given":"J A","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital , Shatin, NT , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T F","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital , Shatin, NT , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C S","family":"Cockram","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital , Shatin, NT , Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1136\/thx.37.12.877","article-title":"Alveolar soft-part sarcoma","volume":"37","author":"Hurt, R.; Bates, M.; Harrison, W.","year":"1982","unstructured":"Hurt, R., Bates, M. & Harrison, W. Alveolar soft-part sarcoma. Thorax 1982, 37: 877-886.","journal-title":"Thorax"},{"issue":"198","key":"ref_2","first-page":"121","article-title":"Alveolar soft-part sarcoma","volume":"1966","unstructured":"Lieberman, P.H., Foote, F.W. Jr., Stewart, F.W. & Berg, J.W. Alveolar soft-part sarcoma. JAMA 1966, 198: 121-125.","journal-title":"JAMA"},{"issue":"20","key":"ref_3","first-page":"426432","article-title":"Alveolar soft-part sarcoma","volume":"1969","author":"Asvall, J.E.; Hoeg, K.; Kleppe, K.; Prydz, P.E.","unstructured":"Asvall, J.E., Hoeg, K., Kleppe, K. & Prydz, P.E. Alveolar soft-part sarcoma. Clin Radiol 1969, 20: 426432.","journal-title":"Clin Radiol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/1097-0142(197109)28:3<577::AID-CNCR2820280308>3.0.CO;2-0","article-title":"Radiation therapy in alveolar soft-part sarcoma","volume":"28","author":"Ruberfeld, S.","year":"1971","unstructured":"Ruberfeld, S. Radiation therapy in alveolar soft-part sarcoma. Cancer 1971, 28: 577-580.","journal-title":"Cancer"},{"key":"ref_5","first-page":"214","article-title":"The alveolar soft-part sarcoma: review of the literature and report of a case","volume":"32","author":"Balfour, R.S.","year":"1974","unstructured":"Balfour, R.S. The alveolar soft-part sarcoma: review of the literature and report of a case. J Oral Surg 1974, 32: 214-220.","journal-title":"J Oral Surg"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/00007611-197603000-00011","article-title":"Alveolar soft-part sarcoma","volume":"69","author":"Blumberg, M.B.; Chang, C.H.","year":"1976","unstructured":"Blumberg, M.B. & Chang, C.H. Alveolar soft-part sarcoma. South Med J 1976, 69: 282-285.","journal-title":"South Med J"},{"key":"ref_7","first-page":"47","article-title":"Pulmonary resection and chemotherapy for metastatic alveolar soft-part sarcoma","volume":"1981","author":"Baum, E.S.; Fickenscher, L.; Nachman, J.B.; Idriss, F.","unstructured":"Baum, E.S., Fickenscher, L., Nachman, J.B. & Idriss, F. Pulmonary resection and chemotherapy for metastatic alveolar soft-part sarcoma. Cancer 1981, 47: 1946-1948.","journal-title":"Cancer"},{"issue":"5","key":"ref_8","first-page":"100","article-title":"Alveolar soft-part sarcomas. Structurally characteristic tumors of uncertain histogenesis","volume":"1952","author":"Christopherson, W.M.; Foote, Jr., F.W.; Stewart, F.W.","unstructured":"Christopherson, W.M., Foote, F.W. Jr. & Stewart, F.W. Alveolar soft-part sarcomas. Structurally characteristic tumors of uncertain histogenesis. Cancer 1952, 5: 100-111.","journal-title":"Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/00000478-198201000-00001","article-title":"Alveolar soft-part sarcoma - a malignant angioreninoma","volume":"6","author":"DeSchryver-Kecskemetic, K.; Kraus, F.T.; Engleman, W.; Lacy, P.E.","year":"1982","unstructured":"DeSchryver-Kecskemetic, K., Kraus, F.T., Engleman, W. & Lacy, P.E. Alveolar soft-part sarcoma - a malignant angioreninoma. Am J Surg Pathol 1982, 6: 5-18.","journal-title":"Am J Surg Pathol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/751\/386\/50078392\/postgradmedj-64-386.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/751\/386\/50078392\/postgradmedj-64-386.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T03:17:19Z","timestamp":1683256639000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/64\/751\/386\/7047824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5,1]]},"references-count":9,"journal-issue":{"issue":"751","published-online":{"date-parts":[[1988,5,1]]},"published-print":{"date-parts":[[1988,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.64.751.386","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1988,5]]},"published":{"date-parts":[[1988,5,1]]}}}