{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:14:43Z","timestamp":1760908483602},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"752","license":[{"start":{"date-parts":[[1988,6,1]],"date-time":"1988-06-01T00:00:00Z","timestamp":581126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Three different thiazide potassium-sparing diuretic combinations were given to elderly patients for heart failure. Eighty patients received their allocated combinations for 3 years and had 6-monthly measurements of plasma potassium. A further 84 were recruited for study but 29 died within 6 months and 55 had to be withdrawn from the trial. The triamterene-containing preparation was discontinued most frequently (6\/44) because of hypokalaemia (plasma potassium less than 3.0 mmol\/l); amiloride (5\/44) and spironolactone (1\/47). The median fall in plasma potassium over 3 years in those patients not withdrawn because of hypokalaemia was similar in each case (P greater than 0.05) and possibly failed to reach significance because of the withdrawal rate (9%). The trend was for a greater fall in those patients taking triamterene. The spironolactone-containing preparation may be the least unsatisfactory of the three.<\/jats:p>","DOI":"10.1136\/pgmj.64.752.434","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"434-437","source":"Crossref","is-referenced-by-count":2,"title":["Progressive hypokalaemia in elderly patients taking three thiazide potassium-sparing diuretic combinations for thirty-six months"],"prefix":"10.1093","volume":"64","author":[{"given":"N","family":"Sawyer","sequence":"first","affiliation":[{"name":"St Mary\u2019s Hospital, Praed Street , London W2 JNY , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Gabriel","sequence":"additional","affiliation":[{"name":"St Mary\u2019s Hospital, Praed Street , London W2 JNY , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1136\/bmj.280.6218.905","article-title":"Hypokalaemia and diuretics: An analysis of publications","volume":"1","author":"Morgan, D.B.; Davidson, C.","year":"1980","unstructured":"Morgan, D.B. & Davidson, C. Hypokalaemia and diuretics: An analysis of publications. Br Med J 1980, 1: 905-908.","journal-title":"Br Med J"},{"issue":"23","key":"ref_2","first-page":"17","article-title":"Potassium-sparing diuretics - when are they really needed?","volume":"1985","unstructured":"Potassium-sparing diuretics - when are they really needed? Drug Ther Bull 1985, 23: 17-20.","journal-title":"Drug Ther Bull"},{"issue":"39","key":"ref_3","first-page":"239","article-title":"The cardiovascular risks of thiazide diuretics","volume":"1986","author":"Freis, E.D.","unstructured":"Freis, E.D. The cardiovascular risks of thiazide diuretics. Clin Pharmacol Ther 1986, 39: 239-244.","journal-title":"Clin Pharmacol Ther"},{"issue":"61","key":"ref_4","first-page":"29","article-title":"A study of two diuretic\/potassium combinations in heart failure","volume":"1985","author":"Hussain, M.; Walton, K.; Davidson, C.; Morgan, D.B.","unstructured":"Hussain, M., Walton, K., Davidson, C. & Morgan, D.B. 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