{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:13:05Z","timestamp":1759342385714},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"754","license":[{"start":{"date-parts":[[1988,8,1]],"date-time":"1988-08-01T00:00:00Z","timestamp":586396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Seventy-nine patients with chronic lymphocytic leukaemia were evaluated for the presence of autoimmune diseases and autoantibodies. One patient has polymyositis and two additional patients presented with features suggestive of pernicious anaemia and chronic active hepatitis.<\/jats:p>\n               <jats:p>The Coombs\u2019 direct test was positive in 7% and immune thrombocytopenia was present in 8.1% of patients. Five (7%) patients had M-protein in the serum. No increased frequency of other autoantibodies was noted in our study group.<\/jats:p>\n               <jats:p>We conclude that the propensity to develop antibodies is restricted only to the haematopoietic system and that there is no increased frequency of non-haematological autoimmune diseases in chronic lymphatic leukaemia.<\/jats:p>","DOI":"10.1136\/pgmj.64.754.590","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T21:05:27Z","timestamp":1230584727000},"page":"590-592","source":"Crossref","is-referenced-by-count":12,"title":["Autoimmunity in chronic lymphocytic leukaemia"],"prefix":"10.1093","volume":"64","author":[{"given":"M","family":"Lischner","sequence":"first","affiliation":[{"name":"Haematology Division and Department of Internal Medicine \u2018D\u2019, Beilinson Medical Center, Petah Tiqva and Tel Aviv University , Sackler School of Medicine , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Prokocimer","sequence":"additional","affiliation":[{"name":"Haematology Division and Department of Internal Medicine \u2018D\u2019, Beilinson Medical Center, Petah Tiqva and Tel Aviv University , Sackler School of Medicine , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Zolberg","sequence":"additional","affiliation":[{"name":"Haematology Division and Department of Internal Medicine \u2018D\u2019, Beilinson Medical Center, Petah Tiqva and Tel Aviv University , Sackler School of Medicine , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Shaklai","sequence":"additional","affiliation":[{"name":"Haematology Division and Department of Internal Medicine \u2018D\u2019, Beilinson Medical Center, Petah Tiqva and Tel Aviv University , Sackler School of Medicine , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,8,1]]},"reference":[{"key":"ref_1","first-page":"96","article-title":"The chronic leukemias: a review of disease manifestations and the aims of therapy","volume":"1967","author":"Bergsagel, D.E.","unstructured":"Bergsagel, D.E. The chronic leukemias: a review of disease manifestations and the aims of therapy. Can Med Assoc J 1967, 96: 1615-1620.","journal-title":"Can Med Assoc J"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/archinte.1976.03630010046008","article-title":"Idiopathic thrombocytopenic purpura complicating chronic lymphatic leukemia","volume":"136","author":"Carey, R.W.; McGinnis, A.; Jacobson, B.M.; Carralho, A.","year":"1976","unstructured":"Carey, R.W., McGinnis, A., Jacobson, B.M. & Carralho, A. Idiopathic thrombocytopenic purpura complicating chronic lymphatic leukemia. Arch Intern Med 1976, 136: 62-66.","journal-title":"Arch Intern Med"},{"key":"ref_3","first-page":"106","article-title":"Antigranulocyte antibodies in chronic lymphocytic leukemia and other chronic lymphoproliferative disorders","volume":"1","author":"Rustagi, P.; Zolkowski, H.T.; Currie, M.; Luge, G.","year":"1983","unstructured":"Rustagi, P., Zolkowski, H.T., Currie, M. & Luge, G. Antigranulocyte antibodies in chronic lymphocytic leukemia and other chronic lymphoproliferative disorders. Blood 1983, 62 (Suppl. 1): 106 (abstract).","journal-title":"Blood"},{"issue":"103","key":"ref_4","first-page":"101","article-title":"Chronic lymphatic leukemia","volume":"1985","author":"Gale, R.P.; Foon, K.A.","unstructured":"Gale, R.P. & Foon, K.A. Chronic lymphatic leukemia. Ann Intern Med 1985, 103: 101-102.","journal-title":"Ann Intern Med"},{"key":"ref_5","first-page":"378","article-title":"Immune complex disease","volume-title":"Harrison's Principles of Internal Medicine","author":"Gilliland, B.; Mannik, M.","year":"1983","unstructured":"Gilliland, B. & Mannik, M. Immune complex disease. In: Petersdorf, R.G., Adams, R.D., Braunwald, E. Isselbacher, K.J., Martin, J.B. & Wilson, J.D. (eds) Harrison's Principles of Internal Medicine, 10th edition McGraw-Hill, New York, 1983, pp. 378-382.","edition":"10th edition"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0002-9343(81)90243-6","article-title":"Peripheral destruction of platelets in chronic lymphocytic leukemia: recognition, prognosis and therapeutic implications","volume":"71","author":"Rubinstein, D.B.; Longo, D.L.","year":"1981","unstructured":"Rubinstein, D.B. & Longo, D.L. Peripheral destruction of platelets in chronic lymphocytic leukemia: recognition, prognosis and therapeutic implications. Am J Med 1981, 71: 729-732.","journal-title":"Am J Med"},{"issue":"19","key":"ref_7","first-page":"23","article-title":"Autoimmune thrombocytopenic purpura (ITP type) with chronic lymphatic leukemia","volume":"1962","author":"Ebbe, S.; Wittles, B.; Dameshek, A.","unstructured":"Ebbe, S., Wittles, B. & Dameshek, A. Autoimmune thrombocytopenic purpura (ITP type) with chronic lymphatic leukemia. Blood 1962, 19: 23-27.","journal-title":"Blood"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1172\/JCI110713","article-title":"Tgamma (T) cells suppress growth of erythroid colonyforming units in pure red cell aplasia of B-cell chronic lymphocytic leukemia","volume":"70","author":"Managan, K.D.; Chikkapa, G.; Farley, P.C.","year":"1982","unstructured":"Managan, K.D., Chikkapa, G. & Farley, P.C. Tgamma (T) cells suppress growth of erythroid colonyforming units in pure red cell aplasia of B-cell chronic lymphocytic leukemia. J Clin Invest 1982, 70: 1148-1156.","journal-title":"J Clin Invest"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1001\/archinte.1974.00320220123016","article-title":"Pure red cell aplasia and chronic lymphocytic leukemia","volume":"134","author":"Abeloff, M.D.; Waterbury, L.","year":"1974","unstructured":"Abeloff, M.D. & Waterbury, L. Pure red cell aplasia and chronic lymphocytic leukemia. Arch Intern Med 1974, 134: 721-724.","journal-title":"Arch Intern Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/ajh.2830190310","article-title":"Autoimmune hyperthyroidism and thrombocytopenia developed in a patient with chronic lymphocytic leukemia","volume":"19","author":"Hauybenstock, A.; Zalusky, R.","year":"1985","unstructured":"Hauybenstock, A. & Zalusky, R. Autoimmune hyperthyroidism and thrombocytopenia developed in a patient with chronic lymphocytic leukemia. Am J Hemat 1985, 19: 281-283.","journal-title":"Am J Hemat"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000181721","article-title":"Immune deposit nephritis and single component cryoglobulinemia associated with chronic lymphocytic leukemia","volume":"24","author":"Gilboa, N.; Durnate, D.; Guggenheim, S.","year":"1979","unstructured":"Gilboa, N., Durnate, D., Guggenheim, S. et al. Immune deposit nephritis and single component cryoglobulinemia associated with chronic lymphocytic leukemia. Nephron 1979, 24: 223-231.","journal-title":"Nephron"},{"issue":"98","key":"ref_12","first-page":"12","article-title":"Cold urticaria with cryoglobulinemia in a patient with chronic lymphocytic leukemia","volume":"1986","author":"Rawnsley, H.M.; Shelley, W.B.","unstructured":"Rawnsley, H.M. & Shelley, W.B. Cold urticaria with cryoglobulinemia in a patient with chronic lymphocytic leukemia. Arch Dermatol 1986, 98: 12-17.","journal-title":"Arch Dermatol"},{"key":"ref_13","first-page":"47","article-title":"Increase in T lymphocytes in B cell chronic lymphocytic leukaemia","volume":"1981","author":"Catovsky, D.; Lauria, F.; Matutes, E.","unstructured":"Catovsky, D., Lauria, F., Matutes, E. et al. Increase in T lymphocytes in B cell chronic lymphocytic leukaemia. Br J Haematol 1981, 47: 539-544.","journal-title":"Br J Haematol"},{"issue":"57","key":"ref_14","first-page":"418","article-title":"Abnormal T cell subpopulation function in CLL: excessive suppressor T and deficient helper T activity with respect to B cell proliferation","volume":"1981","author":"Kay, N.E.","unstructured":"Kay, N.E. Abnormal T cell subpopulation function in CLL: excessive suppressor T and deficient helper T activity with respect to B cell proliferation. Blood 1981, 57: 418-420.","journal-title":"Blood"},{"issue":"1","key":"ref_15","first-page":"3","article-title":"Xradiation and alkylating agents as possible 'trigger' mechanism in the autoimmune complications of malignant lymphoproliferative disease","volume":"1966","author":"Lewis, R.B.; Schwartz, R.S.; Demeshek, W.","unstructured":"Lewis, R.B., Schwartz, R.S. & Demeshek, W. Xradiation and alkylating agents as possible 'trigger' mechanism in the autoimmune complications of malignant lymphoproliferative disease. Clin Exp Immnunol 1966, 1: 3-11.","journal-title":"Clin Exp Immnunol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/754\/590\/50078900\/postgradmedj-64-590.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/64\/754\/590\/50078900\/postgradmedj-64-590.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T03:39:57Z","timestamp":1683257997000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/64\/754\/590\/7047947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,8,1]]},"references-count":15,"journal-issue":{"issue":"754","published-online":{"date-parts":[[1988,8,1]]},"published-print":{"date-parts":[[1988,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.64.754.590","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1988,8]]},"published":{"date-parts":[[1988,8,1]]}}}